8QV7

Crystal structure of human TDO with alpha-methyl-L-tryptophan

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Tryptophan 2,3-dioxygenase	polymer	355	42463.6	4	UniProt (P48775) Pfam (PF03301) In PDB	Homo sapiens (human)
2	A, B, C, D	alpha-methyl-L-tryptophan	non-polymer		218.3	4	Chemie (ZIQ)
3	A, B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4		water	water		18.0	34	Chemie (HOH)

Sequence modifications

A, B, C, D: 39 - 389 (UniProt: P48775)

PDB	External Database	Details
Glu 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag
His 393	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	169854.4
Non-Polymers*	Number of molecules	6
	Total formula weight	1057.2
All*	Total formula weight	170911.6

*Water molecules are not included.