8QUG
KRAS-G12C in Complex with Compound 1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GTPase KRas | polymer | 170 | 19358.8 | 1 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
2 | A | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
3 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A | (4S)-2-azanyl-4-methyl-4-[3-[2-[(2S)-2-methyl-1,4-diazepan-1-yl]pyrimidin-4-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile | non-polymer | 450.6 | 1 | Chemie (WYU) | |||
5 | water | water | 18.0 | 204 | Chemie (HOH) |
Sequence modifications
A: 1 - 164 (UniProt: P01116)
PDB | External Database | Details |
---|---|---|
Gly 0 | - | expression tag |
Cys 12 | Gly 12 | engineered mutation |
Ser 118 | Cys 118 | engineered mutation |
Gly 151 | Arg 151 | variant |
Asp 153 | Glu 153 | variant |
Lys 165 | - | expression tag |
His 166 | - | expression tag |
Lys 167 | - | expression tag |
Glu 168 | - | expression tag |
Lys 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 19358.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 942.4 | |
All* | Total formula weight | 20301.2 |