8QUC
Cryo-EM Structure of Human Kv3.1 in Complex with Modulator AUT1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, D, C) | Potassium voltage-gated channel subfamily C member 1 | polymer | 518 | 58850.1 | 4 | UniProt (P48547) Pfam (PF02214) Pfam (PF00520) | Homo sapiens (human) | |
| 2 | E, P, T, W (A, B, D, C) | (5R)-5-ethyl-3-[6-(3-methoxy-4-methyl-phenoxy)pyridin-3-yl]imidazolidine-2,4-dione | non-polymer | 341.4 | 4 | Chemie (WY9) PubChem (53230344) PubChem (53241831) PubChem (75982906) | |||
| 3 | F, I, J, Q (A, B) | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE | non-polymer | 734.0 | 4 | Chemie (PCF) PubChem (3032281) PubChem (6138) PubChem (452110) | |||
| 4 | G, R, U, X (A, B, D, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | H, S, V, Y (A, B, D, C) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) PubChem (65082) PubChem (363416) PubChem (500055) PubChem (13301926) PubChem (13301927) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (155804219) PubChem (169132514) PubChem (60078761) PubChem (73440805) PubChem (99567469) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 6 | K, L, M, N, O (A) | POTASSIUM ION | non-polymer | 39.1 | 5 | Chemie (K) PubChem (813) | |||
| 7 | AA, BA, CA, Z (B, D, C, A) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A, B, D, C: 1 - 511 (UniProt: P48547)
| PDB | External Database | Details |
|---|---|---|
| His 22 | Tyr 22 | engineered mutation |
| Ala 512 | - | expression tag |
| Glu 513 | - | expression tag |
| Asn 514 | - | expression tag |
| Leu 515 | - | expression tag |
| Tyr 516 | - | expression tag |
| Phe 517 | - | expression tag |
| Gln 518 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 235400.3 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 6705.6 | |
| All* | Total formula weight | 242105.9 |
