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8QT2

Crystal structure of human Sirt2 in complex with the super-slow substrate TNFn-6

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
NAD-dependent protein deacetylase sirtuin-2polymer30434416.71UniProt (Q8IXJ6)
Pfam (PF02146)
Homo sapiens (human)Regulatory protein SIR2 homolog 2,SIR2-like protein 2
2B
(B)
Peptide-based super-slow substrate TNFn-6polymer101007.11Homo sapiens
3C
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
4D
(A)
1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
5E
(A)
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOLnon-polymer209.21Chemie (BTB)
6F
(A)
(R,R)-2,3-BUTANEDIOLnon-polymer90.11Chemie (BU3)
7G
(B)
3-dodecylsulfanyl-2,2-dimethyl-propanoic acidnon-polymer302.51Chemie (WU8)
8H, I
(A, B)
waterwater18.0228Chemie (HOH)
Sequence modifications
A: 56 - 356 (UniProt: Q8IXJ6)
PDBExternal DatabaseDetails
Gly 53-expression tag
His 54-expression tag
Met 55-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight35423.8
Non-Polymers*Number of molecules5
Total formula weight729.4
All*Total formula weight36153.2
*Water molecules are not included.

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PDB entries from 2025-07-23

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