8QSG
Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 86 (1124384).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, J) | 14-3-3 protein sigma | polymer | 236 | 26542.9 | 2 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B, D (H, S) | BRAF peptide pS365 | polymer | 9 | 1012.9 | 2 | Homo sapiens | ||
| 3 | E, J (A, J) | 1-[(5~{R})-2-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,7-diazaspiro[4.4]nonan-7-yl]-2-chloranyl-ethanone | non-polymer | 439.7 | 2 | Chemie (WQ9) | |||
| 4 | F, G, H, L, M... (A, J) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 5 | I, K (A, J) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | O, P, Q, R (A, H, J, S) | water | water | 18.0 | 260 | Chemie (HOH) |
Sequence modifications
A, J: 1 - 231 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 55111.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1096.2 | |
| All* | Total formula weight | 56207.9 |
