8QMZ

Soluble epoxide hydrolase in complex with RK4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Bifunctional epoxide hydrolase 2	polymer	367	41951.1	4	UniProt (P34913) Pfam (PF00561) In PDB	Homo sapiens (human)
2	A, B, C, D	(3~{a}~{R},6~{a}~{S})-~{N}-[(2,4-dichlorophenyl)methyl]-2-(4-methylphenyl)sulfonyl-3,3~{a},4,5,6,6~{a}-hexahydro-1~{H}-cyclopenta[c]pyrrole-5-carboxamide	non-polymer		467.4	4	Chemie (W6O)
3	A, B, C, D	1,2-ETHANEDIOL	non-polymer		62.1	16	Chemie (EDO)
4		water	water		18.0	841	Chemie (HOH)

Sequence modifications

A, B, C, D: 222 - 555 (UniProt: P34913)

PDB	External Database	Details
Met 198	-	initiating methionine
Gly 199	-	expression tag
Ser 200	-	expression tag
Ser 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag
Ser 208	-	expression tag
Ser 209	-	expression tag
Gly 210	-	expression tag
Leu 211	-	expression tag
Val 212	-	expression tag
Pro 213	-	expression tag
Arg 214	-	expression tag
Gly 215	-	expression tag
Ser 216	-	expression tag
His 217	-	expression tag
Met 218	-	expression tag
Ala 219	-	expression tag
Ser 220	-	expression tag
Met 221	-	expression tag
Leu 556	-	expression tag
Leu 557	-	expression tag
Glu 558	-	expression tag
His 559	-	expression tag
His 560	-	expression tag
His 561	-	expression tag
His 562	-	expression tag
His 563	-	expression tag
His 564	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	167804.3
Non-Polymers*	Number of molecules	20
	Total formula weight	2862.7
All*	Total formula weight	170667.1

*Water molecules are not included.