8QJR
BRG1 bromodomain in complex with VBC via compound 17
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Elongin-B | polymer | 104 | 11748.4 | 2 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | B, E (B, E) | Elongin-C | polymer | 97 | 10974.6 | 2 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 3 | C, F (C, F) | von Hippel-Lindau disease tumor suppressor | polymer | 162 | 18702.3 | 2 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 4 | G, H (G, H) | Transcription activator BRG1 | polymer | 121 | 14230.4 | 2 | UniProt (P51532) Pfam (PF00439) | Homo sapiens (human) | ATP-dependent helicase SMARCA4,BRG1-associated factor 190A,BAF190A,Mitotic growth and transcription activator,Protein BRG-1,Protein brahma homolog 1,SNF2-beta,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 |
| 5 | I, J, K, L, P... (B, C, F, G) | PHOSPHATE ION | non-polymer | 95.0 | 7 | Chemie (PO4) | |||
| 6 | M (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | N, R (C, F) | (2S,4R)-1-[(2R)-2-[3-[2-[4-[3-[4-[(1R,5S)-3-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]oxycyclobutyl]oxypiperidin-1-yl]ethoxy]-1,2-oxazol-5-yl]-3-methyl-butanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide | non-polymer | 1068.3 | 2 | Chemie (VLH) | |||
| 8 | O (E) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 9 | AA, T, U, V, W... (H, A, B, C, D...) | water | water | 18.0 | 57 | Chemie (HOH) |
Sequence modifications
B, E: 17 - 112 (UniProt: Q15369)
C, F: 54 - 213 (UniProt: P40337)
G, H: 1451 - 1569 (UniProt: P51532)
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 1449 | - | expression tag |
| Met 1450 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 111311.5 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2928.9 | |
| All* | Total formula weight | 114240.4 |
