8QJI
Crystal structure of GSK3b in complex with N-(4-(5-(1,2,4-oxadiazol-3-yl)thiophen-2-yl)pyridin-2-yl)cyclopropanecarboxamide inhibitor (TW362)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glycogen synthase kinase-3 beta | polymer | 364 | 41584.6 | 1 | UniProt (P49841) Pfam (PF00069) | Homo sapiens (human) | GSK-3 beta,Serine/threonine-protein kinase GSK3B |
| 2 | B (A) | N-[4-[5-(1,2,4-oxadiazol-3-yl)thiophen-2-yl]pyridin-2-yl]cyclopropanecarboxamide | non-polymer | 312.3 | 1 | Chemie (VNG) | |||
| 3 | C (A) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 26 - 383 (UniProt: P49841)
| PDB | External Database | Details |
|---|---|---|
| Glu 384 | - | expression tag |
| Asn 385 | - | expression tag |
| Leu 386 | - | expression tag |
| Tyr 387 | - | expression tag |
| Phe 388 | - | expression tag |
| Gln 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41584.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 312.3 | |
| All* | Total formula weight | 41897.0 |
