8QJI
Crystal structure of GSK3b in complex with N-(4-(5-(1,2,4-oxadiazol-3-yl)thiophen-2-yl)pyridin-2-yl)cyclopropanecarboxamide inhibitor (TW362)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Glycogen synthase kinase-3 beta | polymer | 364 | 41584.6 | 1 | UniProt (P49841) Pfam (PF00069) In PDB | Homo sapiens (human) | GSK-3 beta,Serine/threonine-protein kinase GSK3B |
2 | A | N-[4-[5-(1,2,4-oxadiazol-3-yl)thiophen-2-yl]pyridin-2-yl]cyclopropanecarboxamide | non-polymer | 312.3 | 1 | Chemie (VNG) | |||
3 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 26 - 383 (UniProt: P49841)
PDB | External Database | Details |
---|---|---|
Glu 384 | - | expression tag |
Asn 385 | - | expression tag |
Leu 386 | - | expression tag |
Tyr 387 | - | expression tag |
Phe 388 | - | expression tag |
Gln 389 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 41584.6 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 312.3 | |
All* | Total formula weight | 41897.0 |