8QHJ
Human Carbonic Anhydrase XII mimic in complex with Lasamide (2,4-Dichloro-5-sulfamoyl benzoic acid)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic anhydrase 2 | polymer | 260 | 29233.9 | 1 | UniProt (P00918) Pfam (PF00194) | Homo sapiens (human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II,Cyanamide hydratase CA2 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | 2,4-dichloro-5-sulfamoylbenzoic acid | non-polymer | 270.1 | 1 | Chemie (V8I) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A: 1 - 260 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Ser 65 | Ala 65 | engineered mutation |
| Lys 67 | Asn 67 | engineered mutation |
| Asn 69 | Glu 69 | engineered mutation |
| Thr 91 | Ile 91 | engineered mutation |
| Ala 130 | Phe 130 | conflict |
| Ser 131 | Gly 131 | conflict |
| Ser 134 | Val 134 | conflict |
| Asn 203 | Leu 203 | engineered mutation |
| Thr 205 | Cys 205 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29233.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 427.6 | |
| All* | Total formula weight | 29661.4 |
