8QHG

Human Carbonic Anhydrase IX mimic in complex with Lasamide (2,4-Dichloro 5-sulfamoyl benzoic acid)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Carbonic anhydrase 2	polymer	266	30055.7	1	UniProt (P00918) Pfam (PF00194)	Homo sapiens (human)
2	B (A)	2,4-dichloro-5-sulfamoylbenzoic acid	non-polymer		270.1	1	Chemie (V8I)
3	C (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D (A)	NICKEL (II) ION	non-polymer		58.7	1	Chemie (NI)
5	E (A)	water	water		18.0	68	Chemie (HOH)

Sequence modifications

A: 1 - 261 (UniProt: P00918)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ser 65	Ala 65	engineered mutation
Gln 67	Asn 67	engineered mutation
Thr 69	Glu 69	engineered mutation
Leu 91	Ile 91	engineered mutation
Val 131	Phe 130	engineered mutation
Asp 132	Gly 131	engineered mutation
Leu 135	Val 134	engineered mutation
Glu 170	Lys 169	engineered mutation
Ala 204	Leu 203	engineered mutation
Gly 206	Cys 205	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	30055.7
Non-Polymers*	Number of molecules	3
	Total formula weight	394.2
All*	Total formula weight	30449.9

*Water molecules are not included.