8QH0

Crystal structure of the SARS-CoV-2 RBD with the antibody Cv2.3194

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Spike protein S1	polymer	206	23068.7	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2
2	B (H)	Cv2.3194 Heavy chain	polymer	229	24379.3	1		Homo sapiens
3	C (L)	IGK@ protein	polymer	211	22821.3	1	UniProt (Q6PJF2) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (human)
4	D (B)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	E (A)	PROLINE	non-polymer		115.1	1	Chemie (PRO)
6	F, G (A, H)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
7	H, I, J (A, H, L)	water	water		18.0	384	Chemie (HOH)

Sequence modifications

A: 331 - 528 (UniProt: P0DTC2)

PDB	External Database	Details
Phe 367	Val 367	variant
Gly 529	-	expression tag
Ser 530	-	expression tag
Gly 531	-	expression tag
Asp 532	-	expression tag
Asp 533	-	expression tag
Asp 534	-	expression tag
Asp 535	-	expression tag
Lys 536	-	expression tag

L: 1 - 214 (UniProt: Q6PJF2)

PDB	External Database	Details
Gly 9	Ala 29	conflict
Ser 28	Ile 48	conflict
Ser 32	Ala 52	conflict
Ile 49	Met 69	conflict
Tyr 50	Phe 70	conflict
Ala 52	Ser 72	conflict
Gly 61	Asp 81	conflict
Ile 86	Val 106	conflict
-	Tyr 112	deletion
-	Gly 113	deletion
-	Ser 114	deletion
-	Ser 115	deletion
Gly 92	Gln 116	conflict
Val 93	Gly 117	conflict
Gly 97	Pro 121	conflict
Glu 102	Asp 126	conflict
Asn 215	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	70269.3
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	3
	Total formula weight	299.3
All*	Total formula weight	70993.0

*Water molecules are not included.