8QFX
Human Angiotensin-1 converting enzyme N-domain in complex with the lactotripeptide IPP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Angiotensin-converting enzyme, soluble form | polymer | 628 | 72493.4 | 4 | UniProt (P12821) Pfam (PF01401) | Homo sapiens (human) | |
| 2 | E, F, G, H (E, F, G, H) | ILE-PRO-PRO | polymer | 3 | 325.4 | 4 | Bos taurus | ||
| 3 | I, J, L, M (I, J, L, N) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 4 | In PDB GlyTouCan (G86851RC) | |||
| 4 | K (K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 5 | N, O (P, R) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | CB, KA, P, TB (C, B, A, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 7 | DB, LA, Q, UB (C, B, A, D) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 8 | EB, MA, R, VB (C, B, A, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 9 | IB, S, SA, SB, W (C, A, B, D) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 5 | Chemie (PGE) | |||
| 10 | T (A) | DODECAETHYLENE GLYCOL | non-polymer | 546.6 | 1 | Chemie (12P) | |||
| 11 | U, WB (A, D) | 3,6,9,12,15,18,21,24,27-NONAOXANONACOSANE-1,29-DIOL | non-polymer | 458.5 | 2 | Chemie (XPE) | |||
| 12 | AA, CA, FB, NA, PA... (A, C, B, D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 11 | Chemie (PEG) | |||
| 13 | AC, BA, BB, BC, CC... (D, A, C, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 18 | Chemie (EDO) | |||
| 14 | FA, GC, HA, HC, IA... (A, D, C, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 13 | Chemie (NAG) | |||
| 15 | EC, GA, OB, YA (D, A, C, B) | beta-D-mannopyranose | non-polymer | 180.2 | 4 | Chemie (BMA) | |||
| 16 | DC, NB, WA (D, C, B) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 17 | AB, IC (B, D) | alpha-L-fucopyranose | non-polymer | 164.2 | 2 | Chemie (FUC) | |||
| 18 | GB, XB (C, D) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
| 19 | HB (C) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 20 | LC, MC, NC, OC, PC... (A, B, C, D, E...) | water | water | 18.0 | 2325 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 628 (UniProt: P12821)
| PDB | External Database | Details |
|---|---|---|
| Gln 9 | Asn 38 | engineered mutation |
| Gln 25 | Asn 54 | engineered mutation |
| Gln 82 | Asn 111 | engineered mutation |
| Gln 117 | Asn 146 | engineered mutation |
| Gln 131 | Asn 160 | engineered mutation |
| Gln 289 | Asn 318 | engineered mutation |
| Arg 545 | Gln 574 | engineered mutation |
| Leu 576 | Pro 605 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 291275.0 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 2888.7 | |
| Non-Polymers* | Number of molecules | 74 |
| Total formula weight | 9728.3 | |
| All* | Total formula weight | 303892.1 |
