8QEG
Crystal structure of the G11 protein heterotrimer bound to YM-254890 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein subunit alpha-11 | polymer | 352 | 41139.9 | 1 | UniProt (P29992) Pfam (PF00503) | Homo sapiens (human) | G alpha-11,G-protein subunit alpha-11,Guanine nucleotide-binding protein G(y) subunit alpha |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 344 | 37671.1 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 5 | E, F, G, H, I... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 6 | J (A) | N-METHYL-ALPHA-BETA-DEHYDROALANINE | non-polymer | 101.1 | 1 | Chemie (DAM) | |||
| 7 | K (A) | (2R)-2-hydroxy-3-phenylpropanoic acid | non-polymer | 166.2 | 1 | Chemie (HF2) | |||
| 8 | L (A) | N-METHYLCARBONYLTHREONINE | non-polymer | 161.2 | 1 | Chemie (THC) | |||
| 9 | M (A) | N,O-dimethyl-L-threonine | non-polymer | 147.2 | 1 | Chemie (OTH) | |||
| 10 | N, O (A) | (2S,3R)-2-amino-3-hydroxy-4-methylpentanoic acid | non-polymer | 147.2 | 2 | Chemie (HL2) | |||
| 11 | S (B) | N-methyl-L-alanine | non-polymer | 103.1 | 1 | Chemie (MAA) | |||
| 12 | T (B) | ALANINE | non-polymer | 89.1 | 1 | Chemie (ALA) | |||
| 13 | U (B) | ACETYL GROUP | non-polymer | 44.1 | 1 | Chemie (ACE) | |||
| 14 | V, W, X (A, B, G) | water | water | 18.0 | 802 | Chemie (HOH) |
Sequence modifications
A: 36 - 359 (UniProt: P29992)
B: 2 - 340 (UniProt: P62873)
G: 2 - 72 (UniProt: P59768)
| PDB | External Database | Details |
|---|---|---|
| Gly 8 | - | expression tag |
| Cys 9 | - | expression tag |
| Thr 10 | - | expression tag |
| Leu 11 | - | expression tag |
| Ser 12 | - | expression tag |
| Ala 13 | - | expression tag |
| Glu 14 | - | expression tag |
| Asp 15 | - | expression tag |
| Lys 16 | - | expression tag |
| Ala 17 | - | expression tag |
| Ala 18 | - | expression tag |
| Val 19 | - | expression tag |
| Glu 20 | - | expression tag |
| Arg 21 | - | expression tag |
| Ser 22 | - | expression tag |
| Lys 23 | - | expression tag |
| Met 24 | - | expression tag |
| Ile 25 | - | expression tag |
| Asp 26 | - | expression tag |
| Arg 27 | - | expression tag |
| Asn 28 | - | expression tag |
| Leu 29 | - | expression tag |
| Arg 30 | - | expression tag |
| Glu 31 | - | expression tag |
| Asp 32 | - | expression tag |
| Gly 33 | - | expression tag |
| Glu 34 | - | expression tag |
| Lys 35 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 69 | Cys 68 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 86656.1 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2046.0 | |
| All* | Total formula weight | 88702.0 |
