8QDI
compound 1b bound KMT9 crystal structure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Methyltransferase N6AMT1 | polymer | 203 | 21804.1 | 1 | UniProt (Q9Y5N5) Pfam (PF05175) | Homo sapiens (human) | HemK methyltransferase family member 2,M.HsaHemK2P,Lysine N-methyltransferase 9,Methylarsonite methyltransferase N6AMT1,Protein N(5)-glutamine methyltransferase |
| 2 | B (B) | Multifunctional methyltransferase subunit TRM112-like protein | polymer | 126 | 14272.4 | 1 | UniProt (Q9UI30) Pfam (PF03966) | Homo sapiens (human) | tRNA methyltransferase 112 homolog |
| 3 | C (A) | (2~{S})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[2-[(2~{R})-pyrrolidin-2-yl]ethyl]amino]-2-azanyl-butanoic acid | non-polymer | 464.5 | 1 | Chemie (QII) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 184 | Chemie (HOH) |
Sequence modifications
A: 13 - 214 (UniProt: Q9Y5N5)
B: 3 - 126 (UniProt: Q9UI30)
| PDB | External Database | Details |
|---|---|---|
| Ser 12 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36076.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 464.5 | |
| All* | Total formula weight | 36541.0 |
