8QA5
MTHFR + SAH asymmetric dis-inhibited state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Methylenetetrahydrofolate reductase (NADPH) | polymer | 663 | 75461.2 | 2 | UniProt (P42898) Pfam (PF02219) Pfam (PF21895) In PDB | Homo sapiens (human) | |
| 2 | A | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
| 3 | A, B | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) |
Sequence modifications
A, B: 1 - 656 (UniProt: P42898)
| PDB | External Database | Details |
|---|---|---|
| Ala 429 | Glu 429 | conflict |
| Gln 594 | Arg 594 | conflict |
| Ala 657 | - | expression tag |
| Glu 658 | - | expression tag |
| Asn 659 | - | expression tag |
| Leu 660 | - | expression tag |
| Tyr 661 | - | expression tag |
| Phe 662 | - | expression tag |
| Gln 663 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 150922.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1554.4 | |
| All* | Total formula weight | 152476.8 |
