8Q9S
STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE INHIBITOR SGC-CK2-1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Casein kinase II subunit alpha' | polymer | 364 | 42879.9 | 1 | UniProt (P19784) Pfam (PF00069) In PDB | Homo sapiens (human) | CK II alpha' |
2 | A | ~{N}-[5-[[3-cyano-7-(cyclopropylamino)-3~{H}-pyrazolo[1,5-a]pyrimidin-5-yl]amino]-2-methyl-phenyl]propanamide | non-polymer | 375.4 | 1 | Chemie (QBE) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
4 | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence modifications
A: 1 - 350 (UniProt: P19784)
PDB | External Database | Details |
---|---|---|
Met -13 | - | initiating methionine |
Gly -12 | - | expression tag |
Ser -11 | - | expression tag |
Ser -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Ser -3 | - | expression tag |
Gln -2 | - | expression tag |
Asp -1 | - | expression tag |
Pro 0 | - | expression tag |
Ser 336 | Cys 336 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 42879.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 499.6 | |
All* | Total formula weight | 43379.4 |