8Q95

Crystal structure of the SARS-CoV-2 BA.1 RBD with neutralizing-VHHs Ma16B06 and Ma3F05

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Spike protein S1	polymer	187	21376.0	1	UniProt (P0DTC2) Pfam (PF09408) In PDB	Severe acute respiratory syndrome coronavirus 2
2	B	Nanobody Ma3F05	polymer	131	14260.6	1		Vicugna pacos
3	C	Nanobody Ma16B06	polymer	120	13182.5	1		Vicugna pacos
4		water	water		18.0	355	Chemie (HOH)

Sequence modifications

A: 334 - 517 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 331	-	expression tag
Gly 332	-	expression tag
Ser 333	-	expression tag
Asp 339	Gly 339	variant
Asp 343	Asn 343	conflict
Leu 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Ser 391	Cys 391	conflict
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
Ser 446	Gly 446	variant
Asn 477	Ser 477	variant
Lys 478	Thr 478	variant
Ala 484	Glu 484	variant
Arg 493	Gln 493	variant
Ser 496	Gly 496	variant
Arg 498	Gln 498	variant
Tyr 501	Asn 501	variant
His 505	Tyr 505	variant

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	48819.1
All*	Total formula weight	48819.1

*Water molecules are not included.