8Q6I

Cholera holotoxin variant (chimera with E. coli heat-labile enterotoxin, 1 C-terminal substitution)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cholera enterotoxin subunit A	polymer	240	27256.0	1	UniProt (P01555) Pfam (PF01375)	Vibrio cholerae O1	Cholera enterotoxin,A chain
2	B, C, D, E, F (D, E, F, G, H)	Cholera enterotoxin subunit B	polymer	103	11623.3	5	UniProt (P01556) Pfam (PF01376)	Vibrio cholerae O1	Cholera enterotoxin B chain,Cholera enterotoxin gamma chain,Choleragenoid
3	G, H (A)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
4	I, J, K, M, N... (D, E, F, G, H)	GLYCEROL	non-polymer		92.1	11	Chemie (GOL)
5	L, O (D, E)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
6	AA, V, W, X, Y... (H, A, D, E, F...)	water	water		18.0	408	Chemie (HOH)

Sequence modifications

A: 1 - 240 (UniProt: P01555)

PDB	External Database	Details
Glu 229	Asp 247	engineered mutation

D, E, F, G, H: 1 - 103 (UniProt: P01556)

PDB	External Database	Details
His 18	Tyr 39	engineered mutation
Thr 47	Ile 68	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	85372.4
Non-Polymers*	Number of molecules	15
	Total formula weight	1271.3
All*	Total formula weight	86643.6

*Water molecules are not included.