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8Q6H

HUMAN PI4KIIIB IN COMPLEX WITH COVALENTLY BOUND INHIBITOR (COMPOUND 11)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1APhosphatidylinositol 4-kinase betapolymer42448403.61UniProt (Q9UBF8)
UniProt (A0A0B4J1S8)
Pfam (PF00454)
In PDB
Homo sapiens (human)PI4K-beta,PI4Kbeta,PtdIns 4-kinase beta,NPIK,PI4K92,PI4KIII
2AMAGNESIUM IONnon-polymer24.31Chemie (MG)
3A3-(3-fluorosulfonyloxy-4-methoxy-phenyl)-7-[(4-fluorosulfonyloxyphenyl)methylamino]-2,5-dimethyl-pyrazolo[1,5-a]pyrimidinenon-polymer554.51Chemie (KI7)
4A1,2-ETHANEDIOLnon-polymer62.11Chemie (EDO)
5waterwater18.0249Chemie (HOH)
Sequence modifications
A: 291 - 503 (UniProt: Q9UBF8)
PDBExternal DatabaseDetails
Gly 290-expression tag
Gln 497Arg 409engineered mutation
Gln 500Arg 412engineered mutation
A: 504 - 801 (UniProt: A0A0B4J1S8)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight48403.6
Non-Polymers*Number of molecules3
Total formula weight640.9
All*Total formula weight49044.5
*Water molecules are not included.

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PDB entries from 2024-05-15

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