8Q6H
HUMAN PI4KIIIB IN COMPLEX WITH COVALENTLY BOUND INHIBITOR (COMPOUND 11)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphatidylinositol 4-kinase beta | polymer | 424 | 48403.6 | 1 | UniProt (Q9UBF8) UniProt (A0A0B4J1S8) Pfam (PF00454) | Homo sapiens (human) | PI4K-beta,PI4Kbeta,PtdIns 4-kinase beta,NPIK,PI4K92,PI4KIII |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C (A) | 3-(3-fluorosulfonyloxy-4-methoxy-phenyl)-7-[(4-fluorosulfonyloxyphenyl)methylamino]-2,5-dimethyl-pyrazolo[1,5-a]pyrimidine | non-polymer | 554.5 | 1 | Chemie (KI7) | |||
| 4 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | E (A) | water | water | 18.0 | 249 | Chemie (HOH) |
Sequence modifications
A: 291 - 503 (UniProt: Q9UBF8)
A: 504 - 801 (UniProt: A0A0B4J1S8)
| PDB | External Database | Details |
|---|---|---|
| Gly 290 | - | expression tag |
| Gln 497 | Arg 409 | engineered mutation |
| Gln 500 | Arg 412 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48403.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 640.9 | |
| All* | Total formula weight | 49044.5 |
