8Q69
Crystal structure of HsRNMT complexed with inhibitor DDD1060606
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | mRNA cap guanine-N7 methyltransferase | polymer | 276 | 32550.6 | 2 | UniProt (O43148) Pfam (PF03291) | Homo sapiens (human) | RG7MT1,mRNA (guanine-N(7))-methyltransferase,mRNA cap methyltransferase,hCMT1,hMet,hcm1p |
| 2 | C, F (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 3 | D, G (A, B) | 1-[(3~{S})-3-(2~{H}-pyrazolo[3,4-b]pyridin-3-yl)piperidin-1-yl]-2-thiophen-3-yl-ethanone | non-polymer | 326.4 | 2 | Chemie (K7R) | |||
| 4 | E, H (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | I (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 405 | Chemie (HOH) |
Sequence modifications
A, B: 165 - 415 (UniProt: O43148)
A, B: 456 - 476 (UniProt: O43148)
A, B: 456 - 476 (UniProt: O43148)
| PDB | External Database | Details |
|---|---|---|
| Gly 416 | - | linker |
| Leu 417 | - | linker |
| Gly 418 | - | linker |
| Cys 419 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65101.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1705.9 | |
| All* | Total formula weight | 66807.0 |
