8Q46
Inward-facing, open2 proteoliposome complex I at 2.6 A. Initially purified in LMNG.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 13086.5 | 1 | UniProt (Q7JAS9) Pfam (PF00507) UniProt (by SIFTS) (P03898) | Bos taurus (cattle) | |
| 2 | B (B) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 216 | 23802.9 | 1 | UniProt (P42026) Pfam (PF01058) | Bos taurus (cattle) | Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit,PSST subunit |
| 3 | C (C) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 266 | 30323.4 | 1 | UniProt (P23709) Pfam (PF00329) | Bos taurus (cattle) | Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 4 | D (D) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 463 | 52678.5 | 1 | UniProt (P17694) Pfam (PF00346) | Bos taurus (cattle) | Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 5 | E (E) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 249 | 27341.5 | 1 | UniProt (P04394) Pfam (PF01257) | Bos taurus (cattle) | NADH dehydrogenase subunit II,NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 6 | F (F) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 464 | 50718.8 | 1 | UniProt (P25708) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) | Bos taurus (cattle) | Complex I-51kD,CI-51kD,NADH dehydrogenase flavoprotein 1,NADH-ubiquinone oxidoreductase 51 kDa subunit |
| 7 | G (G) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 727 | 79532.2 | 1 | UniProt (P15690) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) Pfam (PF00111) | Bos taurus (cattle) | Complex I-75kD,CI-75kD |
| 8 | H (H) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35716.8 | 1 | UniProt (P03887) Pfam (PF00146) | Bos taurus (cattle) | |
| 9 | I (I) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 212 | 23926.4 | 1 | UniProt (P42028) Pfam (PF12838) | Bos taurus (cattle) | Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit,TYKY subunit |
| 10 | J (J) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 175 | 19110.5 | 1 | UniProt (P03924) Pfam (PF00499) | Bos taurus (cattle) | NADH dehydrogenase subunit 6 |
| 11 | K (K) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10828.2 | 1 | UniProt (P03902) Pfam (PF00420) | Bos taurus (cattle) | NADH dehydrogenase subunit 4L |
| 12 | L (L) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 606 | 68355.9 | 1 | UniProt (P03920) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) | Bos taurus (cattle) | NADH dehydrogenase subunit 5 |
| 13 | M (M) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 52158.8 | 1 | UniProt (P03910) Pfam (PF01059) Pfam (PF00361) | Bos taurus (cattle) | NADH dehydrogenase subunit 4 |
| 14 | N (N) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39302.9 | 1 | UniProt (P03892) Pfam (PF00361) Pfam (PF06444) | Bos taurus (cattle) | NADH dehydrogenase subunit 2 |
| 15 | O (O) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 343 | 39331.0 | 1 | UniProt (P34942) Pfam (PF01712) | Bos taurus (cattle) | Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit |
| 16 | P (P) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 380 | 42913.4 | 1 | UniProt (P34943) Pfam (PF01370) | Bos taurus (cattle) | Complex I-39kD,CI-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit |
| 17 | Q (Q) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 175 | 19841.6 | 1 | UniProt (Q02375) Pfam (PF04800) | Bos taurus (cattle) | Complex I-18 kDa,CI-18 kDa,Complex I-AQDQ,CI-AQDQ,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 18 | R (R) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 124 | 13433.2 | 1 | UniProt (P23934) Pfam (PF10276) | Bos taurus (cattle) | Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit |
| 19 | S (S) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 99 | 11097.8 | 1 | UniProt (Q02370) Pfam (PF05047) | Bos taurus (cattle) | Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit |
| 20 | T, U (T, U) | Acyl carrier protein, mitochondrial | polymer | 156 | 17421.3 | 2 | UniProt (P52505) Pfam (PF00550) | Bos taurus (cattle) | ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
| 21 | V (V) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 116 | 13334.6 | 1 | UniProt (P23935) Pfam (PF04716) | Bos taurus (cattle) | Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 22 | W (W) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 128 | 15083.5 | 1 | UniProt (Q02366) Pfam (PF13233) | Bos taurus (cattle) | Complex I-B14,CI-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 23 | X (X) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 172 | 20124.1 | 1 | UniProt (P42029) Pfam (PF06747) | Bos taurus (cattle) | Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit |
| 24 | Y (Y) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 141 | 14814.1 | 1 | UniProt (Q8HXG6) Pfam (PF02466) | Bos taurus (cattle) | Complex I-B14.7,CI-B14.7,NADH-ubiquinone oxidoreductase subunit B14.7 |
| 25 | Z (Z) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 144 | 16694.4 | 1 | UniProt (Q95KV7) Pfam (PF06212) | Bos taurus (cattle) | Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit |
| 26 | AA (a) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8117.4 | 1 | UniProt (Q02377) Pfam (PF15879) | Bos taurus (cattle) | Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit |
| 27 | BA (b) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 84 | 9399.9 | 1 | UniProt (Q02371) Pfam (PF14987) | Bos taurus (cattle) | |
| 28 | CA (c) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 76 | 8796.2 | 1 | UniProt (Q02376) Pfam (PF15088) | Bos taurus (cattle) | Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit |
| 29 | DA (d) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 120 | 14159.3 | 1 | UniProt (Q02827) Pfam (PF06374) | Bos taurus (cattle) | Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b |
| 30 | EA (e) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 106 | 12694.7 | 1 | UniProt (Q02379) Pfam (PF10200) | Bos taurus (cattle) | Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit |
| 31 | FA (f) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 57 | 6978.1 | 1 | UniProt (Q02378) Pfam (PF08040) | Bos taurus (cattle) | Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 32 | GA (g) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 154 | 17594.9 | 1 | UniProt (Q8HXG5) Pfam (PF10183) | Bos taurus (cattle) | Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit |
| 33 | HA (h) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 189 | 21624.1 | 1 | UniProt (Q02380) Pfam (PF09781) | Bos taurus (cattle) | Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit |
| 34 | IA (i) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 128 | 15592.1 | 1 | UniProt (Q02367) Pfam (PF09782) | Bos taurus (cattle) | |
| 35 | JA (j) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 108 | 12298.9 | 1 | UniProt (Q02374) Pfam (PF14813) | Bos taurus (cattle) | Complex I-AGGG,CI-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit |
| 36 | KA (k) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 98 | 11160.7 | 1 | UniProt (Q02365) Pfam (PF08122) | Bos taurus (cattle) | Complex I-B12,CI-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 37 | LA (l) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 186 | 21678.5 | 1 | UniProt (Q02372) Pfam (PF05821) | Bos taurus (cattle) | Complex I-ASHI,CI-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 38 | MA (m) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 129 | 15248.3 | 1 | UniProt (P48305) Pfam (PF07225) | Bos taurus (cattle) | |
| 39 | NA (n) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 179 | 21827.9 | 1 | UniProt (Q02369) Pfam (PF05347) | Bos taurus (cattle) | Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 40 | OA (o) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 137 | 16428.8 | 1 | UniProt (Q02368) Pfam (PF05676) | Bos taurus (cattle) | Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 41 | PA (p) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 21000.9 | 1 | UniProt (Q02373) Pfam (PF10249) | Bos taurus (cattle) | Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit |
| 42 | QA (q) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 145 | 17157.5 | 1 | UniProt (O97725) Pfam (PF05071) | Bos taurus (cattle) | |
| 43 | RA (r) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 113 | 12737.6 | 1 | UniProt (Q05752) Pfam (PF07347) | Bos taurus (cattle) | Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 44 | SA (s) | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 109 | 11874.5 | 1 | UniProt (P25712) Pfam (PF15880) | Bos taurus (cattle) | Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 45 | AD, DC, FD, GD, LC... (g, N, m, Y, I...) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 24 | Chemie (3PE) | |||
| 46 | AC, CD, HD, IB, JB... (M, h, m, H, q...) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 14 | Chemie (PC1) | |||
| 47 | AB, BC, BD, RC, SB... (B, M, g, Y, L...) | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 7 | Chemie (PLC) | |||
| 48 | DB, EB, FB, KB, LB... (F, G, I, B) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 49 | BB, GB (E, G) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 50 | CB (F) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 51 | HB (G) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 52 | CC, ED, JD, KC, QB... (N, i, q, X, L...) | CARDIOLIPIN | non-polymer | 1464.0 | 7 | Chemie (CDL) | |||
| 53 | HC, VB (R, M) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 54 | EC (O) | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (DGT) | |||
| 55 | FC (O) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 56 | GC (P) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 57 | IC, JC (T, U) | ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate | non-polymer | 584.7 | 2 | Chemie (EHZ) | |||
| 58 | DD (i) | CHOLIC ACID | non-polymer | 408.6 | 1 | Chemie (CHD) | |||
| 59 | ID (o) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) |
Sequence modifications
D: -32 - 430 (UniProt: P17694)
O: -22 - 320 (UniProt: P34942)
| PDB | External Database | Details |
|---|---|---|
| Arg 129 | Gln 162 | variant |
| PDB | External Database | Details |
|---|---|---|
| Lys 255 | Asn 278 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 1044764.4 | |
| Non-Polymers* | Number of molecules | 71 |
| Total formula weight | 49794.7 | |
| All* | Total formula weight | 1094559.1 |
