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8Q19

The Crystal Structure of Human Carbonic Anhydrase IX in Complex with Sulfonamide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DCarbonic anhydrase 9polymer25728186.74UniProt (Q16790)
Pfam (PF00194)
In PDB
Homo sapiens (human)Carbonate dehydratase IX,Carbonic anhydrase IX,CA-IX,CAIX,Membrane antigen MN,P54/58N,Renal cell carcinoma-associated antigen G250,RCC-associated antigen G250,pMW1
2A, B, C, DZINC IONnon-polymer65.44Chemie (ZN)
3A, B, C, D2-but-2-ynyl-1,1,3-tris(oxidanylidene)-1,2-benzothiazole-6-sulfonamidenon-polymer314.34Chemie (IQ2)
4A, B, C, DGLYCEROLnon-polymer92.14Chemie (GOL)
5waterwater18.0488Chemie (HOH)
Sequence modifications
A, B, C, D: 5 - 259 (UniProt: Q16790)
PDBExternal DatabaseDetails
Gly 3-expression tag
Pro 4-expression tag
Ser 42Cys 174engineered mutation
Gln 214Asn 346engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight112746.8
Non-Polymers*Number of molecules12
Total formula weight1887.4
All*Total formula weight114634.2
*Water molecules are not included.

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PDB entries from 2024-06-12

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