8Q18
The Crystal Structure of Human Carbonic Anhydrase IX in Complex with Sulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Carbonic anhydrase 9 | polymer | 257 | 28186.7 | 4 | UniProt (Q16790) Pfam (PF00194) | Homo sapiens (human) | Carbonate dehydratase IX,Carbonic anhydrase IX,CA-IX,CAIX,Membrane antigen MN,P54/58N,Renal cell carcinoma-associated antigen G250,RCC-associated antigen G250,pMW1 |
| 2 | E, H, K, N (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, I, L, O (A, B, C, D) | 1,1,3-tris(oxidanylidene)-2-(2-phenylethyl)-1,2-benzothiazole-6-sulfonamide | non-polymer | 366.4 | 4 | Chemie (IQE) | |||
| 4 | G, J, M, P (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 699 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 5 - 259 (UniProt: Q16790)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Pro 4 | - | expression tag |
| Ser 42 | Cys 174 | engineered mutation |
| Gln 214 | Asn 346 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 112746.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2095.7 | |
| All* | Total formula weight | 114842.5 |
