8Q0F
Inward-facing, open2 proteoliposome complex I at 3.1 A. Initially purified in DDM.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 13086.5 | 1 | UniProt (Q7JAS9) Pfam (PF00507) UniProt (by SIFTS) (P03898) | Bos taurus (cattle) | |
| 2 | B (B) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 216 | 23802.9 | 1 | UniProt (P42026) Pfam (PF01058) | Bos taurus (cattle) | Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit,PSST subunit |
| 3 | C (C) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 266 | 30323.4 | 1 | UniProt (P23709) Pfam (PF00329) | Bos taurus (cattle) | Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 4 | D (D) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 463 | 52678.5 | 1 | UniProt (P17694) Pfam (PF00346) | Bos taurus (cattle) | Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 5 | E (E) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 249 | 27341.5 | 1 | UniProt (P04394) Pfam (PF01257) | Bos taurus (cattle) | NADH dehydrogenase subunit II,NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 6 | F (F) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 464 | 50718.8 | 1 | UniProt (P25708) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) | Bos taurus (cattle) | Complex I-51kD,CI-51kD,NADH dehydrogenase flavoprotein 1,NADH-ubiquinone oxidoreductase 51 kDa subunit |
| 7 | G (G) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 727 | 79532.2 | 1 | UniProt (P15690) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) Pfam (PF00111) | Bos taurus (cattle) | Complex I-75kD,CI-75kD |
| 8 | H (H) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35716.8 | 1 | UniProt (P03887) Pfam (PF00146) | Bos taurus (cattle) | |
| 9 | I (I) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 212 | 23926.4 | 1 | UniProt (P42028) Pfam (PF12838) | Bos taurus (cattle) | Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit,TYKY subunit |
| 10 | J (J) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 175 | 19110.5 | 1 | UniProt (P03924) Pfam (PF00499) | Bos taurus (cattle) | NADH dehydrogenase subunit 6 |
| 11 | K (K) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10828.2 | 1 | UniProt (P03902) Pfam (PF00420) | Bos taurus (cattle) | NADH dehydrogenase subunit 4L |
| 12 | L (L) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 606 | 68355.9 | 1 | UniProt (P03920) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) | Bos taurus (cattle) | NADH dehydrogenase subunit 5 |
| 13 | M (M) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 52158.8 | 1 | UniProt (P03910) Pfam (PF01059) Pfam (PF00361) | Bos taurus (cattle) | NADH dehydrogenase subunit 4 |
| 14 | N (N) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39302.9 | 1 | UniProt (P03892) Pfam (PF00361) Pfam (PF06444) | Bos taurus (cattle) | NADH dehydrogenase subunit 2 |
| 15 | O (O) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 343 | 39331.0 | 1 | UniProt (P34942) Pfam (PF01712) | Bos taurus (cattle) | Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit |
| 16 | P (P) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 380 | 42913.4 | 1 | UniProt (P34943) Pfam (PF01370) | Bos taurus (cattle) | Complex I-39kD,CI-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit |
| 17 | Q (Q) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 175 | 19841.6 | 1 | UniProt (Q02375) Pfam (PF04800) | Bos taurus (cattle) | Complex I-18 kDa,CI-18 kDa,Complex I-AQDQ,CI-AQDQ,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 18 | R (R) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 124 | 13433.2 | 1 | UniProt (P23934) Pfam (PF10276) | Bos taurus (cattle) | Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit |
| 19 | S (S) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 99 | 11097.8 | 1 | UniProt (Q02370) Pfam (PF05047) | Bos taurus (cattle) | Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit |
| 20 | T, U (T, U) | Acyl carrier protein, mitochondrial | polymer | 156 | 17421.3 | 2 | UniProt (P52505) Pfam (PF00550) | Bos taurus (cattle) | ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
| 21 | V (V) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 116 | 13334.6 | 1 | UniProt (P23935) Pfam (PF04716) | Bos taurus (cattle) | Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 22 | W (W) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 128 | 15083.5 | 1 | UniProt (Q02366) Pfam (PF13233) | Bos taurus (cattle) | Complex I-B14,CI-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 23 | X (X) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 172 | 20124.1 | 1 | UniProt (P42029) Pfam (PF06747) | Bos taurus (cattle) | Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit |
| 24 | Y (Y) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 141 | 14814.1 | 1 | UniProt (Q8HXG6) Pfam (PF02466) | Bos taurus (cattle) | Complex I-B14.7,CI-B14.7,NADH-ubiquinone oxidoreductase subunit B14.7 |
| 25 | Z (Z) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 144 | 16694.4 | 1 | UniProt (Q95KV7) Pfam (PF06212) | Bos taurus (cattle) | Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit |
| 26 | AA (a) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8117.4 | 1 | UniProt (Q02377) Pfam (PF15879) | Bos taurus (cattle) | Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit |
| 27 | BA (b) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 84 | 9399.9 | 1 | UniProt (Q02371) Pfam (PF14987) | Bos taurus (cattle) | |
| 28 | CA (c) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 76 | 8796.2 | 1 | UniProt (Q02376) Pfam (PF15088) | Bos taurus (cattle) | Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit |
| 29 | DA (d) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 120 | 14159.3 | 1 | UniProt (Q02827) Pfam (PF06374) | Bos taurus (cattle) | Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b |
| 30 | EA (e) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 106 | 12694.7 | 1 | UniProt (Q02379) Pfam (PF10200) | Bos taurus (cattle) | Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit |
| 31 | FA (f) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 57 | 6978.1 | 1 | UniProt (Q02378) Pfam (PF08040) | Bos taurus (cattle) | Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 32 | GA (g) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 154 | 17594.9 | 1 | UniProt (Q8HXG5) Pfam (PF10183) | Bos taurus (cattle) | Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit |
| 33 | HA (h) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 189 | 21624.1 | 1 | UniProt (Q02380) Pfam (PF09781) | Bos taurus (cattle) | Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit |
| 34 | IA (i) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 128 | 15592.1 | 1 | UniProt (Q02367) Pfam (PF09782) | Bos taurus (cattle) | |
| 35 | JA (j) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 108 | 12298.9 | 1 | UniProt (Q02374) Pfam (PF14813) | Bos taurus (cattle) | Complex I-AGGG,CI-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit |
| 36 | KA (k) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 98 | 11160.7 | 1 | UniProt (Q02365) Pfam (PF08122) | Bos taurus (cattle) | Complex I-B12,CI-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 37 | LA (l) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 186 | 21678.5 | 1 | UniProt (Q02372) Pfam (PF05821) | Bos taurus (cattle) | Complex I-ASHI,CI-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 38 | MA (m) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 129 | 15248.3 | 1 | UniProt (P48305) Pfam (PF07225) | Bos taurus (cattle) | |
| 39 | NA (n) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 179 | 21827.9 | 1 | UniProt (Q02369) Pfam (PF05347) | Bos taurus (cattle) | Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 40 | OA (o) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 137 | 16428.8 | 1 | UniProt (Q02368) Pfam (PF05676) | Bos taurus (cattle) | Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 41 | PA (p) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 21000.9 | 1 | UniProt (Q02373) Pfam (PF10249) | Bos taurus (cattle) | Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit |
| 42 | QA (q) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 145 | 17157.5 | 1 | UniProt (O97725) Pfam (PF05071) | Bos taurus (cattle) | |
| 43 | RA (r) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 113 | 12737.6 | 1 | UniProt (Q05752) Pfam (PF07347) | Bos taurus (cattle) | Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 44 | SA (s) | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 109 | 11874.5 | 1 | UniProt (P25712) Pfam (PF15880) | Bos taurus (cattle) | Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 45 | CD, DC, DD, LB, LC... (m, N, I, Y, K...) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 21 | Chemie (3PE) | |||
| 46 | AC, ED, HB, HD, IB... (M, m, H, q, I...) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 14 | Chemie (PC1) PubChem (65146) PubChem (94190) PubChem (10417837) | |||
| 47 | BC, QC, SC, UB, WA... (M, Y, Z, L, A...) | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 7 | Chemie (PLC) PubChem (65263) PubChem (87507) PubChem (445355) | |||
| 48 | CB, DB, EB, JB, KB... (F, G, I, B) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 49 | AB, FB (E, G) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 50 | BB (F) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) PubChem (710) PubChem (8965) PubChem (23585816) PubChem (643976) PubChem (51435500) PubChem (51435503) PubChem (5702760) PubChem (7048779) PubChem (7048781) PubChem (15559251) | |||
| 51 | GB (G) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) PubChem (813) | |||
| 52 | BD, CC, GD, KC, PB... (i, N, q, X, L...) | CARDIOLIPIN | non-polymer | 1464.0 | 7 | Chemie (CDL) PubChem (17753886) PubChem (5287898) | |||
| 53 | HC, VB (R, M) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 54 | EC (O) | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (DGT) PubChem (177678918) PubChem (136110594) PubChem (135398599) PubChem (135402022) PubChem (135566345) PubChem (136254580) PubChem (136633653) PubChem (136828797) PubChem (136828798) PubChem (137226754) PubChem (137257907) PubChem (171699498) | |||
| 55 | FC (O) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 56 | GC (P) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 57 | IC, JC (T, U) | ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate | non-polymer | 584.7 | 2 | Chemie (EHZ) PubChem (71777704) PubChem (137349255) PubChem (163183360) | |||
| 58 | AD (i) | CHOLIC ACID | non-polymer | 408.6 | 1 | Chemie (CHD) PubChem (16401672) PubChem (16758100) PubChem (18528842) PubChem (20638765) PubChem (303) PubChem (6676) PubChem (122340) PubChem (23636694) PubChem (23640631) PubChem (160636) PubChem (221493) PubChem (23876184) PubChem (16401251) PubChem (24836753) PubChem (24883735) PubChem (376829) PubChem (439520) PubChem (21139644) PubChem (440427) PubChem (43835083) PubChem (44135469) PubChem (1762378) PubChem (44629918) PubChem (44657327) PubChem (45114537) PubChem (45382168) PubChem (46397523) PubChem (46783697) PubChem (637625) PubChem (44339334) PubChem (49791911) PubChem (49796810) PubChem (50989873) PubChem (51432410) PubChem (51546373) PubChem (53298695) PubChem (53393606) PubChem (53477699) PubChem (46780112) PubChem (3246132) PubChem (57937243) PubChem (58133002) PubChem (58582306) PubChem (58984417) PubChem (59032051) PubChem (59316662) PubChem (59877711) PubChem (59963674) PubChem (59997751) PubChem (60076012) PubChem (60098994) PubChem (60114995) PubChem (66678354) PubChem (59130005) PubChem (59381614) PubChem (5283869) PubChem (5283870) PubChem (5283871) PubChem (5283873) PubChem (5283875) PubChem (5283877) PubChem (5283878) PubChem (68097396) PubChem (68131418) PubChem (68318251) PubChem (68338620) PubChem (68372213) PubChem (59903914) PubChem (71260265) PubChem (70649328) PubChem (5302608) PubChem (5315844) PubChem (67122255) PubChem (70824975) PubChem (70930320) PubChem (70930789) PubChem (70960845) PubChem (69904012) PubChem (130213) PubChem (6708709) PubChem (6850901) PubChem (6850905) PubChem (145883) PubChem (70866085) PubChem (71001249) PubChem (239672) PubChem (71314856) PubChem (9802771) PubChem (71752895) PubChem (9846429) PubChem (9866174) PubChem (91810856) PubChem (74765127) PubChem (71172094) PubChem (89830646) PubChem (12080557) PubChem (12303167) PubChem (12303172) PubChem (12303175) PubChem (12303178) PubChem (12303180) PubChem (13020205) PubChem (91128541) PubChem (99564899) PubChem (99565857) PubChem (5283876) PubChem (5283879) PubChem (5283880) PubChem (5283872) PubChem (5283874) PubChem (98044963) PubChem (99565617) PubChem (122645815) PubChem (124161889) PubChem (124318072) PubChem (124488681) PubChem (125037036) PubChem (126577457) PubChem (129274856) PubChem (129274855) PubChem (129359810) PubChem (117684834) PubChem (117767695) PubChem (117944573) PubChem (118241311) PubChem (133135020) PubChem (133126746) PubChem (11350342) PubChem (121232934) PubChem (122537896) PubChem (122537897) PubChem (122644681) PubChem (122644923) PubChem (122646384) PubChem (12303168) PubChem (124328806) PubChem (124364505) PubChem (124425250) PubChem (124488680) PubChem (124511215) PubChem (124518077) PubChem (124518078) PubChem (124518446) PubChem (124761950) PubChem (13020196) PubChem (124841930) PubChem (124896923) PubChem (124896924) PubChem (124896925) PubChem (124896926) PubChem (124904187) PubChem (124904188) PubChem (124906682) PubChem (124906683) PubChem (124914603) PubChem (124914604) PubChem (124914605) PubChem (124914606) PubChem (125027431) PubChem (125037037) PubChem (126422551) PubChem (126422552) PubChem (126577461) PubChem (126672319) PubChem (126969154) PubChem (129106816) PubChem (129460958) PubChem (129600748) PubChem (129628082) PubChem (130220803) PubChem (131700165) PubChem (132441695) PubChem (133548348) PubChem (133612061) PubChem (133655733) PubChem (133687870) PubChem (133688934) PubChem (134462403) PubChem (134555902) PubChem (134866321) PubChem (135373095) PubChem (162771689) PubChem (163059393) PubChem (163059399) PubChem (163059389) PubChem (137474142) PubChem (138107312) PubChem (139248576) PubChem (139291795) PubChem (139372812) PubChem (166858402) PubChem (140618124) PubChem (141854542) PubChem (142134118) PubChem (143658950) PubChem (144316980) PubChem (145264188) PubChem (145714625) PubChem (146030145) PubChem (146665897) PubChem (154033190) PubChem (154036252) PubChem (154747009) PubChem (154825357) PubChem (155275443) PubChem (155605940) PubChem (157048615) PubChem (157269375) PubChem (157351909) PubChem (157383333) PubChem (158041002) PubChem (158420924) PubChem (158675416) PubChem (160081178) PubChem (160743345) PubChem (160917187) PubChem (161973449) PubChem (163059390) PubChem (163059391) PubChem (163059392) PubChem (163059394) PubChem (163059395) PubChem (163059396) PubChem (163059397) PubChem (163059398) PubChem (163059400) PubChem (163452349) PubChem (163452350) PubChem (163452351) PubChem (167344826) PubChem (168841979) PubChem (168841990) PubChem (168845540) PubChem (169410142) PubChem (169436432) PubChem (171721516) PubChem (157060709) | |||
| 59 | FD (o) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) PubChem (11005) |
Sequence modifications
D: -32 - 430 (UniProt: P17694)
O: -22 - 320 (UniProt: P34942)
| PDB | External Database | Details |
|---|---|---|
| Arg 129 | Gln 162 | variant |
| PDB | External Database | Details |
|---|---|---|
| Lys 255 | Asn 278 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 1044764.4 | |
| Non-Polymers* | Number of molecules | 68 |
| Total formula weight | 47550.5 | |
| All* | Total formula weight | 1092314.9 |
