8PZ8
crystal structure of VDR in complex with D-Bishomo-1a,25-dihydroxyvitamin D3 Analog 54
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Vitamin D3 receptor A | polymer | 302 | 34060.7 | 1 | UniProt (Q9PTN2) Pfam (PF00104) In PDB | Danio rerio (zebrafish) | VDR-A,1,25-dihydroxyvitamin D3 receptor A,Nuclear receptor subfamily 1 group I member 1-A |
| 2 | B | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 1 | UniProt (Q15596) In PDB | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | A | (1~{R},3~{R})-5-[(2~{E})-2-[(4~{a}~{R},5~{S},9~{a}~{S})-4~{a}-methyl-5-[(2~{R})-6-methyl-6-oxidanyl-heptan-2-yl]-3,4,5,6,7,8,9,9~{a}-octahydro-2~{H}-benzo[7]annulen-1-ylidene]ethylidene]cyclohexane-1,3-diol | non-polymer | 432.7 | 1 | Chemie (IFU) | |||
| 4 | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
A: 156 - 453 (UniProt: Q9PTN2)
| PDB | External Database | Details |
|---|---|---|
| Gly 152 | - | expression tag |
| Ser 153 | - | expression tag |
| His 154 | - | expression tag |
| Met 155 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35640.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 432.7 | |
| All* | Total formula weight | 36073.2 |
