8PWW

PfRH5 bound to monoclonal antibody MAD8-151

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Reticulocyte-binding protein homolog 5	polymer	338	40962.4	2	UniProt (Q8IFM5) Pfam (PF18515)	Plasmodium falciparum 3D7	PfRH5
2	B, D (B, D)	scFv fragment for antibody MAD8-151	polymer	250	26682.6	2		Homo sapiens
3	E, J (A, C)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
4	F, H, K (A, B, D)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
5	G, I (A, C)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
6	L, M, N, O (A, B, C, D)	water	water		18.0	533	Chemie (HOH)

Sequence modifications

A, C: 140 - 248 (UniProt: Q8IFM5)

PDB	External Database	Details
Tyr 203	Cys 203	engineered mutation
Ala 216	Thr 216	engineered mutation

A, C: 249 - 477 (UniProt: Q8IFM5)

PDB	External Database	Details
Ala 250	Thr 299	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	135289.9
Non-Polymers*	Number of molecules	7
	Total formula weight	612.7
All*	Total formula weight	135902.5

*Water molecules are not included.