8PR3

Cytoplasmic dynein-1 heavy chain bound to JIP3-RH1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, C	C-Jun-amino-terminal kinase-interacting protein 3	polymer	581	65975.4	2	UniProt (Q9UPT6) Pfam (PF09744) Pfam (PF16471) In PDB	Homo sapiens (human)	JIP-3,JNK-interacting protein 3,JNK MAP kinase scaffold protein 3,Mitogen-activated protein kinase 8-interacting protein 3
2	f, m	Cytoplasmic dynein 1 heavy chain 1	polymer	4646	533055.1	2	UniProt (Q14204) Pfam (PF12780) Pfam (PF12777) Pfam (PF12781) Pfam (PF03028) Pfam (PF18198) Pfam (PF18199) Pfam (PF08385) Pfam (PF08393) Pfam (PF12774) Pfam (PF17852) Pfam (PF12775) Pfam (PF22597) In PDB	Homo sapiens (human)	Cytoplasmic dynein heavy chain 1,Dynein heavy chain,cytosolic
3	h, o	Cytoplasmic dynein 1 intermediate chain 2	polymer	612	68442.1	2	UniProt (Q13409) Pfam (PF11540) Pfam (PF00400) In PDB	Homo sapiens (human)	Cytoplasmic dynein intermediate chain 2,Dynein intermediate chain 2,cytosolic,DH IC-2
4	j, E, F	Cytoplasmic dynein 1 light intermediate chain 2	polymer	492	54173.2	3	UniProt (O43237) Pfam (PF05783) In PDB	Homo sapiens (human)	Dynein light intermediate chain 2,cytosolic,LIC-2,LIC53/55

Sequence modifications

B, C: 1 - 560 (UniProt: Q9UPT6)

PDB	External Database	Details
Ser -6	-	expression tag
Asn -5	-	expression tag
Ile -4	-	expression tag
Glu -3	-	expression tag
Phe -2	-	expression tag
Leu -1	-	expression tag
Lys 0	-	expression tag
Gly 561	-	expression tag
Ser 562	-	expression tag
Gly 563	-	expression tag
Ser 564	-	expression tag
Gly 565	-	expression tag
Arg 566	-	expression tag
Trp 567	-	expression tag
Ser 568	-	expression tag
His 569	-	expression tag
Pro 570	-	expression tag
Gln 571	-	expression tag
Phe 572	-	expression tag
Glu 573	-	expression tag
Lys 574	-	expression tag

f, m: 1 - 4646 (UniProt: Q14204)

PDB	External Database	Details
Glu 1567	Arg 1567	engineered mutation
Glu 1610	Lys 1610	engineered mutation

h, o: 1 - 612 (UniProt: Q13409)

PDB	External Database	Details
Ser 484	Thr 484	conflict
Gly 499	Asp 499	conflict

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	1497464.8
All*	Total formula weight	1497464.8

*Water molecules are not included.