8PO0
Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 12 bound to EGFRinsNPG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 332 | 37716.5 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | 1-[3-[7-methoxy-4-[3-(3-methoxyphenyl)-1~{H}-pyrazol-4-yl]quinazolin-6-yl]oxyazetidin-1-yl]propan-1-one | non-polymer | 459.5 | 1 | Chemie (2I6) | |||
| 3 | C (A) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 695 - 1025 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 694 | - | expression tag |
| Gly 773 | - | insertion |
| Asn 774 | - | insertion |
| Pro 775 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37716.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 459.5 | |
| All* | Total formula weight | 38176.0 |
