8PKV
Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 4 (ortho-WRCDPETGEC).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Kelch-like ECH-associated protein 1 | polymer | 316 | 34624.8 | 2 | UniProt (Q14145) Pfam (PF01344) | Homo sapiens (human) | Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19 |
| 2 | C (P) | CP5 | polymer | 12 | 1220.3 | 1 | Homo sapiens | ||
| 3 | D, E, F, U, V (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | G, H, I (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | BA, J, L, M, N... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 6 | AA, CA, K (B, A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 7 | O, P, Q, R, S... (A, B) | SODIUM ION | non-polymer | 23.0 | 8 | Chemie (NA) | |||
| 8 | DA (P) | (2-methylphenyl)methanol | non-polymer | 122.2 | 1 | Chemie (ZK2) | |||
| 9 | EA, FA, GA (A, B, P) | water | water | 18.0 | 383 | Chemie (HOH) |
Sequence modifications
A, B: 312 - 623 (UniProt: Q14145)
| PDB | External Database | Details |
|---|---|---|
| Gly 309 | - | expression tag |
| His 310 | - | expression tag |
| Met 311 | - | expression tag |
| Ser 319 | Cys 319 | conflict |
| Ala 540 | Glu 540 | conflict |
| Ala 542 | Glu 542 | conflict |
| Ser 613 | Cys 613 | conflict |
| Ser 622 | Cys 622 | conflict |
| Ser 624 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 70469.9 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 1603.5 | |
| All* | Total formula weight | 72073.4 |
