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8PKV

Kelch domain of KEAP1 in complex with a ortho-dimethylbenzene linked cyclic peptide 4 (ortho-WRCDEETGEC).

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BKelch-like ECH-associated protein 1polymer31634624.82UniProt (Q14145)
Pfam (PF01344)
In PDB
Homo sapiens (human)Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19
2PCP5polymer121220.31Homo sapiens
3A, BSULFATE IONnon-polymer96.15Chemie (SO4)
4ACHLORIDE IONnon-polymer35.53Chemie (CL)
5B, A1,2-ETHANEDIOLnon-polymer62.17Chemie (EDO)
6B, AGLYCEROLnon-polymer92.13Chemie (GOL)
7A, BSODIUM IONnon-polymer23.08Chemie (NA)
8P(2-methylphenyl)methanolnon-polymer122.21Chemie (ZK2)
9waterwater18.0383Chemie (HOH)
Sequence modifications
A, B: 312 - 623 (UniProt: Q14145)
PDBExternal DatabaseDetails
Gly 309-expression tag
His 310-expression tag
Met 311-expression tag
Ser 319Cys 319conflict
Ala 540Glu 540conflict
Ala 542Glu 542conflict
Ser 613Cys 613conflict
Ser 622Cys 622conflict
Ser 624-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight70469.9
Non-Polymers*Number of molecules27
Total formula weight1603.5
All*Total formula weight72073.4
*Water molecules are not included.

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PDB entries from 2024-06-12

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