8PJG

F11 TCR in complex with Human Leukocyte Antigen class II allotype DR1 presenting P11T->R modified influenza A virus haemagglutinin (HA)306-318 PKYVKQNTLKLAR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA class II histocompatibility antigen, DR alpha chain	polymer	183	21287.1	1	UniProt (P01903) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (human)	MHC class II antigen DRA
2	B (B)	HLA class II histocompatibility antigen, DRB1 beta chain	polymer	191	22211.9	1	UniProt (P01911) Pfam (PF00969) Pfam (PF07654)	Homo sapiens (human)	Human leukocyte antigen DRB1,HLA-DRB1
3	C (C)	Hemagglutinin HA2 chain	polymer	13	1562.9	1	UniProt (P03435) UniProt (by SIFTS) (P03437)	Influenza A virus
4	D (D)	T cell receptor alpha chain constant	polymer	207	22969.6	1		Homo sapiens (human)
5	E (E)	T cell receptor beta constant 1	polymer	241	27323.4	1		Homo sapiens (human)
6	F, G, H, I, J... (B, C, D, E)	1,2-ETHANEDIOL	non-polymer		62.1	15	Chemie (EDO)
7	N, V (D, E)	1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE	non-polymer		162.2	2	Chemie (P4G)
8	AA, W, X, Y, Z (E, A, B, C, D)	water	water		18.0	412	Chemie (HOH)

Sequence modifications

A: 1 - 182 (UniProt: P01903)

PDB	External Database	Details
Met 0	-	initiating methionine

B: 1 - 190 (UniProt: P01911)

PDB	External Database	Details
Met 0	-	initiating methionine
Leu 11	Pro 40	variant
Phe 13	Arg 42	variant
Leu 26	Phe 55	variant
Glu 28	Asp 57	variant
Cys 30	Tyr 59	variant
Ile 31	Phe 60	variant
Tyr 47	Phe 76	variant
Leu 67	Ile 96	variant
Arg 71	Ala 100	variant
Gly 86	Val 115	variant
Glu 96	Gln 125	variant
Arg 133	Leu 162	variant
Val 142	Met 171	variant

C: 1 - 13 (UniProt: P03435)

PDB	External Database	Details
Arg 13	Thr 335	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	95354.9
Non-Polymers*	Number of molecules	17
	Total formula weight	1255.5
All*	Total formula weight	96610.4

*Water molecules are not included.