8PJ5
Structure of human 48S translation initiation complex after eIF2 release prior 60S subunit joining (48S-5)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | Eukaryotic translation initiation factor 5B | polymer | 1220 | 139079.1 | 1 | UniProt (O60841) Pfam (PF00009) Pfam (PF11987) Pfam (PF14578) | Homo sapiens (human) | eIF-5B,Translation initiation factor IF-2 |
| 2 | B (1) | Eukaryotic translation initiation factor 3 subunit B | polymer | 814 | 92593.4 | 1 | UniProt (P55884) Pfam (PF00076) Pfam (PF08662) | Homo sapiens (human) | eIF3b,Eukaryotic translation initiation factor 3 subunit 9,Prt1 homolog,hPrt1,eIF-3-eta,eIF3 p110,eIF3 p116 |
| 3 | C (2) | Eukaryotic translation initiation factor 3 subunit I | polymer | 325 | 36543.8 | 1 | UniProt (Q13347) Pfam (PF00400) Pfam (PF12894) | Homo sapiens (human) | eIF3i,Eukaryotic translation initiation factor 3 subunit 2,TGF-beta receptor-interacting protein 1,TRIP-1,eIF-3-beta,eIF3 p36 |
| 4 | D (3) | Eukaryotic translation initiation factor 3 subunit K | polymer | 218 | 25083.6 | 1 | UniProt (Q9UBQ5) Pfam (PF10075) | Homo sapiens (human) | eIF3k,Eukaryotic translation initiation factor 3 subunit 12,Muscle-specific gene M9 protein,PLAC-24,eIF-3 p25,eIF-3 p28 |
| 5 | E (4) | Eukaryotic translation initiation factor 3 subunit F | polymer | 357 | 37593.6 | 1 | UniProt (O00303) Pfam (PF01398) Pfam (PF13012) | Homo sapiens (human) | eIF3f,Deubiquitinating enzyme eIF3f,Eukaryotic translation initiation factor 3 subunit 5,eIF-3-epsilon,eIF3 p47 |
| 6 | F (5) | Eukaryotic translation initiation factor 3 subunit L | polymer | 564 | 66803.7 | 1 | UniProt (Q9Y262) Pfam (PF10255) | Homo sapiens (human) | eIF3l,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein |
| 7 | G (6) | Eukaryotic translation initiation factor 3 subunit M | polymer | 374 | 42555.8 | 1 | UniProt (Q7L2H7) Pfam (PF01399) Pfam (PF18005) | Homo sapiens (human) | eIF3m,Fetal lung protein B5,hFL-B5,PCI domain-containing protein 1 |
| 8 | H (7) | mRNA | polymer | 255 | 82412.4 | 1 | Homo sapiens | ||
| 9 | I (8) | Eukaryotic translation initiation factor 3 subunit H | polymer | 352 | 39979.3 | 1 | UniProt (O15372) Pfam (PF01398) Pfam (PF19445) | Homo sapiens (human) | eIF3h,Eukaryotic translation initiation factor 3 subunit 3,eIF-3-gamma,eIF3 p40 subunit |
| 10 | J (9) | 60S ribosomal protein L41 | polymer | 25 | 3473.5 | 1 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (human) | HG12,Large ribosomal subunit protein eL41 |
| 11 | K (A) | 18S rRNA | polymer | 1869 | 603245.5 | 1 | Homo sapiens (human) | ||
| 12 | L (B) | 40S ribosomal protein S11 | polymer | 158 | 18468.8 | 1 | UniProt (P62280) Pfam (PF16205) Pfam (PF00366) | Homo sapiens (human) | Small ribosomal subunit protein uS17 |
| 13 | M (C) | 40S ribosomal protein S4, X isoform | polymer | 263 | 29654.9 | 1 | UniProt (P62701) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Homo sapiens (human) | SCR10,Single copy abundant mRNA protein,Small ribosomal subunit protein eS4 |
| 14 | N (D) | 40S ribosomal protein S9 | polymer | 194 | 22641.6 | 1 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (human) | Small ribosomal subunit protein uS4 |
| 15 | O (E) | 40S ribosomal protein S23 | polymer | 143 | 15844.7 | 1 | UniProt (P62266) Pfam (PF00164) | Homo sapiens (human) | Small ribosomal subunit protein uS12 |
| 16 | P (F) | 40S ribosomal protein S30 | polymer | 59 | 6564.7 | 1 | UniProt (P62861) Pfam (PF04758) | Homo sapiens (human) | Small ribosomal subunit protein eS30 |
| 17 | Q (G) | 40S ribosomal protein S7 | polymer | 194 | 22168.9 | 1 | UniProt (P62081) Pfam (PF01251) | Homo sapiens (human) | Small ribosomal subunit protein eS7 |
| 18 | R (H) | 40S ribosomal protein S27 | polymer | 84 | 9480.2 | 1 | UniProt (P42677) Pfam (PF01667) | Homo sapiens (human) | Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27 |
| 19 | S (I) | 40S ribosomal protein S13 | polymer | 151 | 17259.4 | 1 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | Homo sapiens (human) | Small ribosomal subunit protein uS15 |
| 20 | T (J) | 40S ribosomal protein S15a | polymer | 130 | 14865.6 | 1 | UniProt (P62244) Pfam (PF00410) | Homo sapiens (human) | Small ribosomal subunit protein uS8 |
| 21 | U (K) | 40S ribosomal protein S21 | polymer | 83 | 9124.4 | 1 | UniProt (P63220) Pfam (PF01249) | Homo sapiens (human) | Small ribosomal subunit protein eS21 |
| 22 | V (L) | 40S ribosomal protein S2 | polymer | 293 | 31376.5 | 1 | UniProt (P15880) Pfam (PF00333) Pfam (PF03719) | Homo sapiens (human) | 40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5 |
| 23 | W (M) | 40S ribosomal protein S17 | polymer | 135 | 15578.2 | 1 | UniProt (P08708) Pfam (PF00833) | Homo sapiens (human) | Small ribosomal subunit protein eS17 |
| 24 | X (N) | 40S ribosomal protein SA | polymer | 295 | 32883.9 | 1 | UniProt (P08865) Pfam (PF00318) Pfam (PF16122) | Homo sapiens (human) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2 |
| 25 | Y (O) | 40S ribosomal protein S3a | polymer | 264 | 30002.1 | 1 | UniProt (P61247) Pfam (PF01015) | Homo sapiens (human) | Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1 |
| 26 | Z (P) | 40S ribosomal protein S14 | polymer | 151 | 16302.8 | 1 | UniProt (P62263) Pfam (PF00411) | Homo sapiens (human) | Small ribosomal subunit protein uS11 |
| 27 | AA (Q) | 40S ribosomal protein S26 | polymer | 115 | 13047.5 | 1 | UniProt (P62854) Pfam (PF01283) | Homo sapiens (human) | Small ribosomal subunit protein eS26 |
| 28 | BA (R) | 40S ribosomal protein S8 | polymer | 208 | 24263.4 | 1 | UniProt (P62241) Pfam (PF01201) | Homo sapiens (human) | Small ribosomal subunit protein eS8 |
| 29 | CA (S) | 40S ribosomal protein S6 | polymer | 249 | 28751.9 | 1 | UniProt (P62753) Pfam (PF01092) | Homo sapiens (human) | Phosphoprotein NP33,Small ribosomal subunit protein eS6 |
| 30 | DA (T) | 40S ribosomal protein S24 | polymer | 133 | 15463.3 | 1 | UniProt (P62847) Pfam (PF01282) | Homo sapiens (human) | Small ribosomal subunit protein eS24 |
| 31 | EA (V) | 40S ribosomal protein S5 | polymer | 204 | 22913.5 | 1 | UniProt (P46782) Pfam (PF00177) | Homo sapiens (human) | Small ribosomal subunit protein uS7 |
| 32 | FA (Y) | 40S ribosomal protein S16 | polymer | 146 | 16477.4 | 1 | UniProt (P62249) Pfam (PF00380) | Homo sapiens (human) | Small ribosomal subunit protein uS9 |
| 33 | GA (Z) | 40S ribosomal protein S3 | polymer | 243 | 26729.4 | 1 | UniProt (P23396) Pfam (PF07650) Pfam (PF00189) | Homo sapiens (human) | Small ribosomal subunit protein uS3 |
| 34 | HA (a) | 40S ribosomal protein S10 | polymer | 165 | 18933.8 | 1 | UniProt (P46783) Pfam (PF03501) | Homo sapiens (human) | Small ribosomal subunit protein eS10 |
| 35 | IA (b) | 40S ribosomal protein S15 | polymer | 145 | 17076.2 | 1 | UniProt (P62841) Pfam (PF00203) | Homo sapiens (human) | RIG protein,Small ribosomal subunit protein uS19 |
| 36 | JA (c) | Receptor of activated protein C kinase 1 | polymer | 317 | 35115.7 | 1 | UniProt (P63244) Pfam (PF00400) | Homo sapiens (human) | Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1 |
| 37 | KA (d) | 40S ribosomal protein S19 | polymer | 145 | 16091.6 | 1 | UniProt (P39019) Pfam (PF01090) | Homo sapiens (human) | Small ribosomal subunit protein eS19 |
| 38 | LA (e) | 40S ribosomal protein S25 | polymer | 125 | 13776.2 | 1 | UniProt (P62851) Pfam (PF03297) | Homo sapiens (human) | Small ribosomal subunit protein eS25 |
| 39 | MA (f) | 40S ribosomal protein S18 | polymer | 152 | 17759.8 | 1 | UniProt (P62269) Pfam (PF00416) | Homo sapiens (human) | Ke-3,Ke3,Small ribosomal subunit protein uS13 |
| 40 | NA (h) | 40S ribosomal protein S20 | polymer | 119 | 13398.8 | 1 | UniProt (P60866) Pfam (PF00338) | Homo sapiens (human) | Small ribosomal subunit protein uS10 |
| 41 | OA (i) | 40S ribosomal protein S29 | polymer | 56 | 6690.8 | 1 | UniProt (P62273) Pfam (PF00253) | Homo sapiens (human) | Small ribosomal subunit protein uS14 |
| 42 | PA (k) | Ubiquitin | polymer | 156 | 18004.0 | 1 | UniProt (P62979) Pfam (PF00240) Pfam (PF01599) | Homo sapiens (human) | |
| 43 | QA (m) | 40S ribosomal protein S12 | polymer | 132 | 14539.0 | 1 | UniProt (P25398) Pfam (PF01248) | Homo sapiens (human) | Small ribosomal subunit protein eS12 |
| 44 | RA (n) | 40S ribosomal protein S28 | polymer | 69 | 7855.1 | 1 | UniProt (P62857) Pfam (PF01200) | Homo sapiens (human) | Small ribosomal subunit protein eS28 |
| 45 | SA (o) | Eukaryotic translation initiation factor 3 subunit G | polymer | 320 | 35662.0 | 1 | UniProt (O75821) Pfam (PF12353) Pfam (PF00076) | Homo sapiens (human) | eIF3g,Eukaryotic translation initiation factor 3 RNA-binding subunit,eIF-3 RNA-binding subunit,Eukaryotic translation initiation factor 3 subunit 4,eIF-3-delta,eIF3 p42,eIF3 p44 |
| 46 | TA (q) | Eukaryotic translation initiation factor 1A, X-chromosomal | polymer | 144 | 16488.4 | 1 | UniProt (P47813) Pfam (PF01176) | Homo sapiens (human) | eIF-1A X isoform,Eukaryotic translation initiation factor 4C,eIF-4C |
| 47 | UA (u) | Eukaryotic translation initiation factor 3 subunit A | polymer | 1382 | 166903.8 | 1 | UniProt (Q14152) Pfam (PF22591) Pfam (PF01399) | Homo sapiens (human) | eIF3a,Eukaryotic translation initiation factor 3 subunit 10,eIF-3-theta,eIF3 p167,eIF3 p180,eIF3 p185 |
| 48 | VA (v) | Eukaryotic translation initiation factor 3 subunit E | polymer | 445 | 52281.6 | 1 | UniProt (P60228) Pfam (PF09440) Pfam (PF01399) Pfam (PF21357) | Homo sapiens (human) | eIF3e,Eukaryotic translation initiation factor 3 subunit 6,Viral integration site protein INT-6 homolog,eIF-3 p48 |
| 49 | WA (w) | Initiator Met-tRNA-i | polymer | 75 | 24231.5 | 1 | GenBank (174924) | Homo sapiens (human) | |
| 50 | XA (x) | Eukaryotic translation initiation factor 3 subunit D | polymer | 548 | 64060.8 | 1 | UniProt (O15371) Pfam (PF05091) | Homo sapiens (human) | eIF3d,Eukaryotic translation initiation factor 3 subunit 7,eIF-3-zeta,eIF3 p66 |
| 51 | YA (y) | Eukaryotic translation initiation factor 3 subunit C | polymer | 913 | 105503.9 | 1 | UniProt (Q99613) Pfam (PF05470) Pfam (PF01399) | Homo sapiens (human) | eIF3c,Eukaryotic translation initiation factor 3 subunit 8,eIF3 p110 |
| 52 | AC, AD, AE, BB, BC... (A, P, S, f, 0) | MAGNESIUM ION | non-polymer | 24.3 | 91 | Chemie (MG) | |||
| 53 | AB (0) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 54 | LE, OE (Q, k) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
F: 75 - 133 (UniProt: P62861)
| PDB | External Database | Details |
|---|---|---|
| Pro 125 | Lys 125 | conflict |
| Gly 126 | Lys 126 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 51 |
| Total formula weight | 2253599.7 | |
| Non-Polymers* | Number of molecules | 94 |
| Total formula weight | 2865.8 | |
| All* | Total formula weight | 2256465.4 |
