8PJ1
Structure of human 48S translation initiation complex in open codon scanning state (48S-1)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (1) | Eukaryotic translation initiation factor 3 subunit B | polymer | 814 | 92593.4 | 1 | UniProt (P55884) Pfam (PF00076) Pfam (PF08662) | Homo sapiens (human) | eIF3b,Eukaryotic translation initiation factor 3 subunit 9,Prt1 homolog,hPrt1,eIF-3-eta,eIF3 p110,eIF3 p116 |
| 2 | B (2) | Eukaryotic translation initiation factor 3 subunit I | polymer | 325 | 36543.8 | 1 | UniProt (Q13347) Pfam (PF24805) | Homo sapiens (human) | eIF3i,Eukaryotic translation initiation factor 3 subunit 2,TGF-beta receptor-interacting protein 1,TRIP-1,eIF-3-beta,eIF3 p36 |
| 3 | C (3) | Eukaryotic translation initiation factor 3 subunit K | polymer | 218 | 25083.6 | 1 | UniProt (Q9UBQ5) Pfam (PF10075) | Homo sapiens (human) | eIF3k,Eukaryotic translation initiation factor 3 subunit 12,Muscle-specific gene M9 protein,PLAC-24,eIF-3 p25,eIF-3 p28 |
| 4 | D (4) | Eukaryotic translation initiation factor 3 subunit F | polymer | 357 | 37593.6 | 1 | UniProt (O00303) Pfam (PF01398) Pfam (PF13012) | Homo sapiens (human) | eIF3f,Deubiquitinating enzyme eIF3f,Eukaryotic translation initiation factor 3 subunit 5,eIF-3-epsilon,eIF3 p47 |
| 5 | E (5) | Eukaryotic translation initiation factor 3 subunit L | polymer | 564 | 66803.7 | 1 | UniProt (Q9Y262) Pfam (PF10255) | Homo sapiens (human) | eIF3l,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein |
| 6 | F (6) | Eukaryotic translation initiation factor 3 subunit M | polymer | 374 | 42555.8 | 1 | UniProt (Q7L2H7) Pfam (PF01399) Pfam (PF18005) | Homo sapiens (human) | eIF3m,Fetal lung protein B5,hFL-B5,PCI domain-containing protein 1 |
| 7 | G (7) | mRNA | polymer | 255 | 82412.4 | 1 | Homo sapiens | ||
| 8 | H (8) | Eukaryotic translation initiation factor 3 subunit H | polymer | 352 | 39979.3 | 1 | UniProt (O15372) Pfam (PF01398) Pfam (PF19445) | Homo sapiens (human) | eIF3h,Eukaryotic translation initiation factor 3 subunit 3,eIF-3-gamma,eIF3 p40 subunit |
| 9 | I (9) | 60S ribosomal protein L41 | polymer | 25 | 3473.5 | 1 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (human) | HG12,Large ribosomal subunit protein eL41 |
| 10 | J (A) | 18S rRNA | polymer | 1869 | 603245.5 | 1 | GenBank (NR_046235.3) | Homo sapiens (human) | |
| 11 | K (B) | 40S ribosomal protein S11 | polymer | 158 | 18468.8 | 1 | UniProt (P62280) Pfam (PF16205) Pfam (PF00366) | Homo sapiens (human) | Small ribosomal subunit protein uS17 |
| 12 | L (C) | 40S ribosomal protein S4, X isoform | polymer | 263 | 29654.9 | 1 | UniProt (P62701) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Homo sapiens (human) | SCR10,Single copy abundant mRNA protein,Small ribosomal subunit protein eS4 |
| 13 | M (D) | 40S ribosomal protein S9 | polymer | 194 | 22641.6 | 1 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (human) | Small ribosomal subunit protein uS4 |
| 14 | N (E) | 40S ribosomal protein S23 | polymer | 143 | 15844.7 | 1 | UniProt (P62266) Pfam (PF00164) | Homo sapiens (human) | Small ribosomal subunit protein uS12 |
| 15 | O (F) | 40S ribosomal protein S30 | polymer | 59 | 6668.9 | 1 | UniProt (P62861) Pfam (PF04758) | Homo sapiens (human) | Small ribosomal subunit protein eS30 |
| 16 | P (G) | 40S ribosomal protein S7 | polymer | 194 | 22168.9 | 1 | UniProt (P62081) Pfam (PF01251) | Homo sapiens (human) | Small ribosomal subunit protein eS7 |
| 17 | Q (H) | 40S ribosomal protein S27 | polymer | 84 | 9480.2 | 1 | UniProt (P42677) Pfam (PF01667) | Homo sapiens (human) | Metallopan-stimulin 1,MPS-1,Small ribosomal subunit protein eS27 |
| 18 | R (I) | 40S ribosomal protein S13 | polymer | 151 | 17259.4 | 1 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | Homo sapiens (human) | Small ribosomal subunit protein uS15 |
| 19 | S (J) | 40S ribosomal protein S15a | polymer | 130 | 14865.6 | 1 | UniProt (P62244) Pfam (PF00410) | Homo sapiens (human) | Small ribosomal subunit protein uS8 |
| 20 | T (K) | 40S ribosomal protein S21 | polymer | 83 | 9124.4 | 1 | UniProt (P63220) Pfam (PF01249) | Homo sapiens (human) | Small ribosomal subunit protein eS21 |
| 21 | U (L) | 40S ribosomal protein S2 | polymer | 293 | 31376.5 | 1 | UniProt (P15880) Pfam (PF00333) Pfam (PF03719) | Homo sapiens (human) | 40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5 |
| 22 | V (M) | 40S ribosomal protein S17 | polymer | 135 | 15578.2 | 1 | UniProt (P08708) Pfam (PF00833) | Homo sapiens (human) | Small ribosomal subunit protein eS17 |
| 23 | W (N) | 40S ribosomal protein SA | polymer | 295 | 32883.9 | 1 | UniProt (P08865) Pfam (PF00318) Pfam (PF16122) | Homo sapiens (human) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2 |
| 24 | X (O) | 40S ribosomal protein S3a | polymer | 264 | 30002.1 | 1 | UniProt (P61247) Pfam (PF01015) | Homo sapiens (human) | Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1 |
| 25 | Y (P) | 40S ribosomal protein S14 | polymer | 151 | 16302.8 | 1 | UniProt (P62263) Pfam (PF00411) | Homo sapiens (human) | Small ribosomal subunit protein uS11 |
| 26 | Z (Q) | 40S ribosomal protein S26 | polymer | 115 | 13047.5 | 1 | UniProt (P62854) Pfam (PF01283) | Homo sapiens (human) | Small ribosomal subunit protein eS26 |
| 27 | AA (R) | 40S ribosomal protein S8 | polymer | 208 | 24263.4 | 1 | UniProt (P62241) Pfam (PF01201) | Homo sapiens (human) | Small ribosomal subunit protein eS8 |
| 28 | BA (S) | 40S ribosomal protein S6 | polymer | 249 | 28751.9 | 1 | UniProt (P62753) Pfam (PF01092) | Homo sapiens (human) | Phosphoprotein NP33,Small ribosomal subunit protein eS6 |
| 29 | CA (T) | 40S ribosomal protein S24 | polymer | 133 | 15463.3 | 1 | UniProt (P62847) Pfam (PF01282) | Homo sapiens (human) | Small ribosomal subunit protein eS24 |
| 30 | DA (V) | 40S ribosomal protein S5 | polymer | 204 | 22913.5 | 1 | UniProt (P46782) Pfam (PF00177) | Homo sapiens (human) | Small ribosomal subunit protein uS7 |
| 31 | EA (Y) | 40S ribosomal protein S16 | polymer | 146 | 16477.4 | 1 | UniProt (P62249) Pfam (PF00380) | Homo sapiens (human) | Small ribosomal subunit protein uS9 |
| 32 | FA (Z) | 40S ribosomal protein S3 | polymer | 243 | 26729.4 | 1 | UniProt (P23396) Pfam (PF07650) Pfam (PF00189) | Homo sapiens (human) | Small ribosomal subunit protein uS3 |
| 33 | GA (a) | 40S ribosomal protein S10 | polymer | 165 | 18933.8 | 1 | UniProt (P46783) Pfam (PF03501) | Homo sapiens (human) | Small ribosomal subunit protein eS10 |
| 34 | HA (b) | 40S ribosomal protein S15 | polymer | 145 | 17076.2 | 1 | UniProt (P62841) Pfam (PF00203) | Homo sapiens (human) | RIG protein,Small ribosomal subunit protein uS19 |
| 35 | IA (c) | Receptor of activated protein C kinase 1 | polymer | 317 | 35115.7 | 1 | UniProt (P63244) Pfam (PF00400) | Homo sapiens (human) | Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1 |
| 36 | JA (d) | 40S ribosomal protein S19 | polymer | 145 | 16091.6 | 1 | UniProt (P39019) Pfam (PF01090) | Homo sapiens (human) | Small ribosomal subunit protein eS19 |
| 37 | KA (e) | 40S ribosomal protein S25 | polymer | 125 | 13776.2 | 1 | UniProt (P62851) Pfam (PF03297) | Homo sapiens (human) | Small ribosomal subunit protein eS25 |
| 38 | LA (f) | 40S ribosomal protein S18 | polymer | 152 | 17759.8 | 1 | UniProt (P62269) Pfam (PF00416) | Homo sapiens (human) | Ke-3,Ke3,Small ribosomal subunit protein uS13 |
| 39 | MA (h) | 40S ribosomal protein S20 | polymer | 119 | 13398.8 | 1 | UniProt (P60866) Pfam (PF00338) | Homo sapiens (human) | Small ribosomal subunit protein uS10 |
| 40 | NA (i) | 40S ribosomal protein S29 | polymer | 56 | 6690.8 | 1 | UniProt (P62273) Pfam (PF00253) | Homo sapiens (human) | Small ribosomal subunit protein uS14 |
| 41 | OA (k) | Ubiquitin | polymer | 157 | 18075.1 | 1 | UniProt (P62979) Pfam (PF00240) Pfam (PF01599) | Homo sapiens (human) | |
| 42 | PA (m) | 40S ribosomal protein S12 | polymer | 132 | 14539.0 | 1 | UniProt (P25398) Pfam (PF01248) | Homo sapiens (human) | Small ribosomal subunit protein eS12 |
| 43 | QA (n) | 40S ribosomal protein S28 | polymer | 69 | 7855.1 | 1 | UniProt (P62857) Pfam (PF01200) | Homo sapiens (human) | Small ribosomal subunit protein eS28 |
| 44 | RA (o) | Eukaryotic translation initiation factor 3 subunit G | polymer | 320 | 35662.0 | 1 | UniProt (O75821) Pfam (PF12353) Pfam (PF00076) | Homo sapiens (human) | eIF3g,Eukaryotic translation initiation factor 3 RNA-binding subunit,eIF-3 RNA-binding subunit,Eukaryotic translation initiation factor 3 subunit 4,eIF-3-delta,eIF3 p42,eIF3 p44 |
| 45 | SA (p) | Eukaryotic translation initiation factor 1 | polymer | 113 | 12752.5 | 1 | UniProt (P41567) Pfam (PF01253) | Homo sapiens (human) | eIF1,A121,Protein translation factor SUI1 homolog,Sui1iso1 |
| 46 | TA (q) | Eukaryotic translation initiation factor 1A, X-chromosomal | polymer | 144 | 16488.4 | 1 | UniProt (P47813) Pfam (PF01176) | Homo sapiens (human) | eIF-1A X isoform,Eukaryotic translation initiation factor 4C,eIF-4C |
| 47 | UA (r) | Eukaryotic translation initiation factor 2 subunit 1 | polymer | 315 | 36161.2 | 1 | UniProt (P05198) Pfam (PF00575) Pfam (PF07541) | Homo sapiens (human) | Eukaryotic translation initiation factor 2 subunit alpha,eIF-2alpha |
| 48 | VA (s) | Eukaryotic translation initiation factor 2 subunit 2 | polymer | 333 | 38454.5 | 1 | UniProt (P20042) Pfam (PF01873) | Homo sapiens (human) | Eukaryotic translation initiation factor 2 subunit beta,eIF-2-beta |
| 49 | WA (t) | Eukaryotic translation initiation factor 2 subunit 3 | polymer | 472 | 51178.4 | 1 | UniProt (P41091) Pfam (PF00009) Pfam (PF03144) Pfam (PF09173) | Homo sapiens (human) | Eukaryotic translation initiation factor 2 subunit gamma X,eIF-2gX |
| 50 | XA (u) | Eukaryotic translation initiation factor 3 subunit A | polymer | 1382 | 166903.8 | 1 | UniProt (Q14152) Pfam (PF22591) Pfam (PF01399) | Homo sapiens (human) | eIF3a,Eukaryotic translation initiation factor 3 subunit 10,eIF-3-theta,eIF3 p167,eIF3 p180,eIF3 p185 |
| 51 | YA (v) | Eukaryotic translation initiation factor 3 subunit E | polymer | 445 | 52281.6 | 1 | UniProt (P60228) Pfam (PF09440) Pfam (PF01399) Pfam (PF21357) | Homo sapiens (human) | eIF3e,Eukaryotic translation initiation factor 3 subunit 6,Viral integration site protein INT-6 homolog,eIF-3 p48 |
| 52 | ZA (w) | Initiator Met-tRNA-i | polymer | 75 | 24231.5 | 1 | GenBank (174924) | Homo sapiens (human) | |
| 53 | AB (x) | Eukaryotic translation initiation factor 3 subunit D | polymer | 548 | 64060.8 | 1 | UniProt (O15371) Pfam (PF05091) | Homo sapiens (human) | eIF3d,Eukaryotic translation initiation factor 3 subunit 7,eIF-3-zeta,eIF3 p66 |
| 54 | BB (y) | Eukaryotic translation initiation factor 3 subunit C | polymer | 913 | 105503.9 | 1 | UniProt (Q99613) Pfam (PF05470) Pfam (PF01399) Pfam (PF26569) | Homo sapiens (human) | eIF3c,Eukaryotic translation initiation factor 3 subunit 8,eIF3 p110 |
| 55 | AC, AD, AE, BC, BD... (A, f, t) | MAGNESIUM ION | non-polymer | 24.3 | 90 | Chemie (MG) PubChem (888) | |||
| 56 | ME, OE, PE (Q, k, s) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 57 | QE (t) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 58 | SE (w) | METHIONINE | non-polymer | 149.2 | 1 | Chemie (MET) PubChem (876) PubChem (6137) PubChem (84815) |
Sequence modifications
A: 1 - 1869 (GenBank: NR_046235.3)
k: 0 - 156 (UniProt: P62979)
| PDB | External Database | Details |
|---|---|---|
| B8n 1248 | U 4902 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 87 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 54 |
| Total formula weight | 2253242.5 | |
| Non-Polymers* | Number of molecules | 95 |
| Total formula weight | 3056.1 | |
| All* | Total formula weight | 2256298.5 |
