9FYP

Cryo EM structure of the type 3B polymorph of alpha-synuclein at low pH.

Replaces:  8PIC

Summary for 9FYP

• Entry DOI: 10.2210/pdb9fyp/pdb
• EMDB information: 50888
• Descriptor: Alpha-synuclein, CHLORIDE ION (3 entities in total)
• Functional Keywords: amyloid, polymorphism, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 145115.61

Authors

Frey, L.,Qureshi, B.M.,Kwiatkowski, W.,Rhyner, D.,Greenwald, J.,Riek, R. (deposition date: 2024-07-03, release date: 2024-07-17)

• Primary citation: Frey, L.,Ghosh, D.,Qureshi, B.M.,Rhyner, D.,Guerrero-Ferreira, R.,Pokharna, A.,Kwiatkowski, W.,Serdiuk, T.,Picotti, P.,Riek, R.,Greenwald, J.; On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation; Elife, 2024; DOI: 10.1101/2023.06.25.546428

Experimental method

ELECTRON MICROSCOPY (2.23 Å)