9FYP

Cryo EM structure of the type 3B polymorph of alpha-synuclein at low pH.

Replaces:  8PIC

Functional Information from GO Data

Chain	GOid	namespace	contents
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0000149	molecular_function	SNARE binding
I	0000287	molecular_function	magnesium ion binding
I	0000976	molecular_function	transcription cis-regulatory region binding
I	0001774	biological_process	microglial cell activation
I	0001921	biological_process	positive regulation of receptor recycling
I	0001963	biological_process	synaptic transmission, dopaminergic
I	0003779	molecular_function	actin binding
I	0004857	molecular_function	enzyme inhibitor activity
I	0004860	molecular_function	protein kinase inhibitor activity
I	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
I	0005504	molecular_function	fatty acid binding
I	0005507	molecular_function	copper ion binding
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005543	molecular_function	phospholipid binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005640	cellular_component	nuclear outer membrane
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005741	cellular_component	mitochondrial outer membrane
I	0005743	cellular_component	mitochondrial inner membrane
I	0005759	cellular_component	mitochondrial matrix
I	0005764	cellular_component	lysosome
I	0005829	cellular_component	cytosol
I	0005840	cellular_component	ribosome
I	0005856	cellular_component	cytoskeleton
I	0005886	cellular_component	plasma membrane
I	0005938	cellular_component	cell cortex
I	0006749	biological_process	glutathione metabolic process
I	0008017	molecular_function	microtubule binding
I	0008021	cellular_component	synaptic vesicle
I	0008047	molecular_function	enzyme activator activity
I	0008198	molecular_function	ferrous iron binding
I	0008270	molecular_function	zinc ion binding
I	0008289	molecular_function	lipid binding
I	0010040	biological_process	response to iron(II) ion
I	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
I	0014059	biological_process	regulation of dopamine secretion
I	0015629	cellular_component	actin cytoskeleton
I	0015631	molecular_function	tubulin binding
I	0016020	cellular_component	membrane
I	0016079	biological_process	synaptic vesicle exocytosis
I	0016082	biological_process	synaptic vesicle priming
I	0016234	cellular_component	inclusion body
I	0016491	molecular_function	oxidoreductase activity
I	0019894	molecular_function	kinesin binding
I	0019899	molecular_function	enzyme binding
I	0019904	molecular_function	protein domain specific binding
I	0030424	cellular_component	axon
I	0030426	cellular_component	growth cone
I	0030544	molecular_function	Hsp70 protein binding
I	0030659	cellular_component	cytoplasmic vesicle membrane
I	0030672	cellular_component	synaptic vesicle membrane
I	0031092	cellular_component	platelet alpha granule membrane
I	0031115	biological_process	negative regulation of microtubule polymerization
I	0031623	biological_process	receptor internalization
I	0031648	biological_process	protein destabilization
I	0032026	biological_process	response to magnesium ion
I	0032496	biological_process	response to lipopolysaccharide
I	0032991	cellular_component	protein-containing complex
I	0034341	biological_process	response to type II interferon
I	0034599	biological_process	cellular response to oxidative stress
I	0035493	biological_process	SNARE complex assembly
I	0035543	biological_process	positive regulation of SNARE complex assembly
I	0042220	biological_process	response to cocaine
I	0042393	molecular_function	histone binding
I	0042416	biological_process	dopamine biosynthetic process
I	0042802	molecular_function	identical protein binding
I	0043014	molecular_function	alpha-tubulin binding
I	0043025	cellular_component	neuronal cell body
I	0043065	biological_process	positive regulation of apoptotic process
I	0043066	biological_process	negative regulation of apoptotic process
I	0043195	cellular_component	terminal bouton
I	0043274	molecular_function	phospholipase binding
I	0043524	biological_process	negative regulation of neuron apoptotic process
I	0043679	cellular_component	axon terminus
I	0044344	biological_process	cellular response to fibroblast growth factor stimulus
I	0045202	cellular_component	synapse
I	0045807	biological_process	positive regulation of endocytosis
I	0045920	biological_process	negative regulation of exocytosis
I	0045921	biological_process	positive regulation of exocytosis
I	0045963	biological_process	negative regulation of dopamine metabolic process
I	0046872	molecular_function	metal ion binding
I	0048148	biological_process	behavioral response to cocaine
I	0048156	molecular_function	tau protein binding
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0048487	molecular_function	beta-tubulin binding
I	0048488	biological_process	synaptic vesicle endocytosis
I	0048489	biological_process	synaptic vesicle transport
I	0050729	biological_process	positive regulation of inflammatory response
I	0050808	biological_process	synapse organization
I	0051219	molecular_function	phosphoprotein binding
I	0051259	biological_process	protein complex oligomerization
I	0051262	biological_process	protein tetramerization
I	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
I	0051583	biological_process	dopamine uptake involved in synaptic transmission
I	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
I	0051612	biological_process	negative regulation of serotonin uptake
I	0051621	biological_process	regulation of norepinephrine uptake
I	0051622	biological_process	negative regulation of norepinephrine uptake
I	0055074	biological_process	calcium ion homeostasis
I	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
I	0060961	molecular_function	phospholipase D inhibitor activity
I	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
I	0070507	biological_process	regulation of microtubule cytoskeleton organization
I	0070555	biological_process	response to interleukin-1
I	0070840	molecular_function	dynein complex binding
I	0071280	biological_process	cellular response to copper ion
I	0071872	biological_process	cellular response to epinephrine stimulus
I	0097413	cellular_component	Lewy body
I	0097435	biological_process	supramolecular fiber organization
I	0098793	cellular_component	presynapse
I	0099512	cellular_component	supramolecular fiber
I	0140311	molecular_function	protein sequestering activity
I	0141108	molecular_function	transporter regulator activity
I	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
I	1903136	molecular_function	cuprous ion binding
I	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
I	1903421	biological_process	regulation of synaptic vesicle recycling
I	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
I	1904307	biological_process	response to desipramine
I	1904377	biological_process	positive regulation of protein localization to cell periphery
I	1904715	biological_process	negative regulation of chaperone-mediated autophagy
I	1905606	biological_process	regulation of presynapse assembly
I	1990000	biological_process	amyloid fibril formation
I	2000377	biological_process	regulation of reactive oxygen species metabolic process
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0000149	molecular_function	SNARE binding
J	0000287	molecular_function	magnesium ion binding
J	0000976	molecular_function	transcription cis-regulatory region binding
J	0001774	biological_process	microglial cell activation
J	0001921	biological_process	positive regulation of receptor recycling
J	0001963	biological_process	synaptic transmission, dopaminergic
J	0003779	molecular_function	actin binding
J	0004857	molecular_function	enzyme inhibitor activity
J	0004860	molecular_function	protein kinase inhibitor activity
J	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
J	0005504	molecular_function	fatty acid binding
J	0005507	molecular_function	copper ion binding
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005543	molecular_function	phospholipid binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005640	cellular_component	nuclear outer membrane
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005741	cellular_component	mitochondrial outer membrane
J	0005743	cellular_component	mitochondrial inner membrane
J	0005759	cellular_component	mitochondrial matrix
J	0005764	cellular_component	lysosome
J	0005829	cellular_component	cytosol
J	0005840	cellular_component	ribosome
J	0005856	cellular_component	cytoskeleton
J	0005886	cellular_component	plasma membrane
J	0005938	cellular_component	cell cortex
J	0006749	biological_process	glutathione metabolic process
J	0008017	molecular_function	microtubule binding
J	0008021	cellular_component	synaptic vesicle
J	0008047	molecular_function	enzyme activator activity
J	0008198	molecular_function	ferrous iron binding
J	0008270	molecular_function	zinc ion binding
J	0008289	molecular_function	lipid binding
J	0010040	biological_process	response to iron(II) ion
J	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
J	0014059	biological_process	regulation of dopamine secretion
J	0015629	cellular_component	actin cytoskeleton
J	0015631	molecular_function	tubulin binding
J	0016020	cellular_component	membrane
J	0016079	biological_process	synaptic vesicle exocytosis
J	0016082	biological_process	synaptic vesicle priming
J	0016234	cellular_component	inclusion body
J	0016491	molecular_function	oxidoreductase activity
J	0019894	molecular_function	kinesin binding
J	0019899	molecular_function	enzyme binding
J	0019904	molecular_function	protein domain specific binding
J	0030424	cellular_component	axon
J	0030426	cellular_component	growth cone
J	0030544	molecular_function	Hsp70 protein binding
J	0030659	cellular_component	cytoplasmic vesicle membrane
J	0030672	cellular_component	synaptic vesicle membrane
J	0031092	cellular_component	platelet alpha granule membrane
J	0031115	biological_process	negative regulation of microtubule polymerization
J	0031623	biological_process	receptor internalization
J	0031648	biological_process	protein destabilization
J	0032026	biological_process	response to magnesium ion
J	0032496	biological_process	response to lipopolysaccharide
J	0032991	cellular_component	protein-containing complex
J	0034341	biological_process	response to type II interferon
J	0034599	biological_process	cellular response to oxidative stress
J	0035493	biological_process	SNARE complex assembly
J	0035543	biological_process	positive regulation of SNARE complex assembly
J	0042220	biological_process	response to cocaine
J	0042393	molecular_function	histone binding
J	0042416	biological_process	dopamine biosynthetic process
J	0042802	molecular_function	identical protein binding
J	0043014	molecular_function	alpha-tubulin binding
J	0043025	cellular_component	neuronal cell body
J	0043065	biological_process	positive regulation of apoptotic process
J	0043066	biological_process	negative regulation of apoptotic process
J	0043195	cellular_component	terminal bouton
J	0043274	molecular_function	phospholipase binding
J	0043524	biological_process	negative regulation of neuron apoptotic process
J	0043679	cellular_component	axon terminus
J	0044344	biological_process	cellular response to fibroblast growth factor stimulus
J	0045202	cellular_component	synapse
J	0045807	biological_process	positive regulation of endocytosis
J	0045920	biological_process	negative regulation of exocytosis
J	0045921	biological_process	positive regulation of exocytosis
J	0045963	biological_process	negative regulation of dopamine metabolic process
J	0046872	molecular_function	metal ion binding
J	0048148	biological_process	behavioral response to cocaine
J	0048156	molecular_function	tau protein binding
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0048487	molecular_function	beta-tubulin binding
J	0048488	biological_process	synaptic vesicle endocytosis
J	0048489	biological_process	synaptic vesicle transport
J	0050729	biological_process	positive regulation of inflammatory response
J	0050808	biological_process	synapse organization
J	0051219	molecular_function	phosphoprotein binding
J	0051259	biological_process	protein complex oligomerization
J	0051262	biological_process	protein tetramerization
J	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
J	0051583	biological_process	dopamine uptake involved in synaptic transmission
J	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
J	0051612	biological_process	negative regulation of serotonin uptake
J	0051621	biological_process	regulation of norepinephrine uptake
J	0051622	biological_process	negative regulation of norepinephrine uptake
J	0055074	biological_process	calcium ion homeostasis
J	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
J	0060961	molecular_function	phospholipase D inhibitor activity
J	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
J	0070507	biological_process	regulation of microtubule cytoskeleton organization
J	0070555	biological_process	response to interleukin-1
J	0070840	molecular_function	dynein complex binding
J	0071280	biological_process	cellular response to copper ion
J	0071872	biological_process	cellular response to epinephrine stimulus
J	0097413	cellular_component	Lewy body
J	0097435	biological_process	supramolecular fiber organization
J	0098793	cellular_component	presynapse
J	0099512	cellular_component	supramolecular fiber
J	0140311	molecular_function	protein sequestering activity
J	0141108	molecular_function	transporter regulator activity
J	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
J	1903136	molecular_function	cuprous ion binding
J	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
J	1903421	biological_process	regulation of synaptic vesicle recycling
J	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
J	1904307	biological_process	response to desipramine
J	1904377	biological_process	positive regulation of protein localization to cell periphery
J	1904715	biological_process	negative regulation of chaperone-mediated autophagy
J	1905606	biological_process	regulation of presynapse assembly
J	1990000	biological_process	amyloid fibril formation
J	2000377	biological_process	regulation of reactive oxygen species metabolic process
K	0000122	biological_process	negative regulation of transcription by RNA polymerase II
K	0000149	molecular_function	SNARE binding
K	0000287	molecular_function	magnesium ion binding
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0001774	biological_process	microglial cell activation
K	0001921	biological_process	positive regulation of receptor recycling
K	0001963	biological_process	synaptic transmission, dopaminergic
K	0003779	molecular_function	actin binding
K	0004857	molecular_function	enzyme inhibitor activity
K	0004860	molecular_function	protein kinase inhibitor activity
K	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
K	0005504	molecular_function	fatty acid binding
K	0005507	molecular_function	copper ion binding
K	0005509	molecular_function	calcium ion binding
K	0005515	molecular_function	protein binding
K	0005543	molecular_function	phospholipid binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005634	cellular_component	nucleus
K	0005640	cellular_component	nuclear outer membrane
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005741	cellular_component	mitochondrial outer membrane
K	0005743	cellular_component	mitochondrial inner membrane
K	0005759	cellular_component	mitochondrial matrix
K	0005764	cellular_component	lysosome
K	0005829	cellular_component	cytosol
K	0005840	cellular_component	ribosome
K	0005856	cellular_component	cytoskeleton
K	0005886	cellular_component	plasma membrane
K	0005938	cellular_component	cell cortex
K	0006749	biological_process	glutathione metabolic process
K	0008017	molecular_function	microtubule binding
K	0008021	cellular_component	synaptic vesicle
K	0008047	molecular_function	enzyme activator activity
K	0008198	molecular_function	ferrous iron binding
K	0008270	molecular_function	zinc ion binding
K	0008289	molecular_function	lipid binding
K	0010040	biological_process	response to iron(II) ion
K	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
K	0014059	biological_process	regulation of dopamine secretion
K	0015629	cellular_component	actin cytoskeleton
K	0015631	molecular_function	tubulin binding
K	0016020	cellular_component	membrane
K	0016079	biological_process	synaptic vesicle exocytosis
K	0016082	biological_process	synaptic vesicle priming
K	0016234	cellular_component	inclusion body
K	0016491	molecular_function	oxidoreductase activity
K	0019894	molecular_function	kinesin binding
K	0019899	molecular_function	enzyme binding
K	0019904	molecular_function	protein domain specific binding
K	0030424	cellular_component	axon
K	0030426	cellular_component	growth cone
K	0030544	molecular_function	Hsp70 protein binding
K	0030659	cellular_component	cytoplasmic vesicle membrane
K	0030672	cellular_component	synaptic vesicle membrane
K	0031092	cellular_component	platelet alpha granule membrane
K	0031115	biological_process	negative regulation of microtubule polymerization
K	0031623	biological_process	receptor internalization
K	0031648	biological_process	protein destabilization
K	0032026	biological_process	response to magnesium ion
K	0032496	biological_process	response to lipopolysaccharide
K	0032991	cellular_component	protein-containing complex
K	0034341	biological_process	response to type II interferon
K	0034599	biological_process	cellular response to oxidative stress
K	0035493	biological_process	SNARE complex assembly
K	0035543	biological_process	positive regulation of SNARE complex assembly
K	0042220	biological_process	response to cocaine
K	0042393	molecular_function	histone binding
K	0042416	biological_process	dopamine biosynthetic process
K	0042802	molecular_function	identical protein binding
K	0043014	molecular_function	alpha-tubulin binding
K	0043025	cellular_component	neuronal cell body
K	0043065	biological_process	positive regulation of apoptotic process
K	0043066	biological_process	negative regulation of apoptotic process
K	0043195	cellular_component	terminal bouton
K	0043274	molecular_function	phospholipase binding
K	0043524	biological_process	negative regulation of neuron apoptotic process
K	0043679	cellular_component	axon terminus
K	0044344	biological_process	cellular response to fibroblast growth factor stimulus
K	0045202	cellular_component	synapse
K	0045807	biological_process	positive regulation of endocytosis
K	0045920	biological_process	negative regulation of exocytosis
K	0045921	biological_process	positive regulation of exocytosis
K	0045963	biological_process	negative regulation of dopamine metabolic process
K	0046872	molecular_function	metal ion binding
K	0048148	biological_process	behavioral response to cocaine
K	0048156	molecular_function	tau protein binding
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0048487	molecular_function	beta-tubulin binding
K	0048488	biological_process	synaptic vesicle endocytosis
K	0048489	biological_process	synaptic vesicle transport
K	0050729	biological_process	positive regulation of inflammatory response
K	0050808	biological_process	synapse organization
K	0051219	molecular_function	phosphoprotein binding
K	0051259	biological_process	protein complex oligomerization
K	0051262	biological_process	protein tetramerization
K	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
K	0051583	biological_process	dopamine uptake involved in synaptic transmission
K	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
K	0051612	biological_process	negative regulation of serotonin uptake
K	0051621	biological_process	regulation of norepinephrine uptake
K	0051622	biological_process	negative regulation of norepinephrine uptake
K	0055074	biological_process	calcium ion homeostasis
K	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
K	0060961	molecular_function	phospholipase D inhibitor activity
K	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
K	0070507	biological_process	regulation of microtubule cytoskeleton organization
K	0070555	biological_process	response to interleukin-1
K	0070840	molecular_function	dynein complex binding
K	0071280	biological_process	cellular response to copper ion
K	0071872	biological_process	cellular response to epinephrine stimulus
K	0097413	cellular_component	Lewy body
K	0097435	biological_process	supramolecular fiber organization
K	0098793	cellular_component	presynapse
K	0099512	cellular_component	supramolecular fiber
K	0140311	molecular_function	protein sequestering activity
K	0141108	molecular_function	transporter regulator activity
K	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
K	1903136	molecular_function	cuprous ion binding
K	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
K	1903421	biological_process	regulation of synaptic vesicle recycling
K	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
K	1904307	biological_process	response to desipramine
K	1904377	biological_process	positive regulation of protein localization to cell periphery
K	1904715	biological_process	negative regulation of chaperone-mediated autophagy
K	1905606	biological_process	regulation of presynapse assembly
K	1990000	biological_process	amyloid fibril formation
K	2000377	biological_process	regulation of reactive oxygen species metabolic process
L	0000122	biological_process	negative regulation of transcription by RNA polymerase II
L	0000149	molecular_function	SNARE binding
L	0000287	molecular_function	magnesium ion binding
L	0000976	molecular_function	transcription cis-regulatory region binding
L	0001774	biological_process	microglial cell activation
L	0001921	biological_process	positive regulation of receptor recycling
L	0001963	biological_process	synaptic transmission, dopaminergic
L	0003779	molecular_function	actin binding
L	0004857	molecular_function	enzyme inhibitor activity
L	0004860	molecular_function	protein kinase inhibitor activity
L	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
L	0005504	molecular_function	fatty acid binding
L	0005507	molecular_function	copper ion binding
L	0005509	molecular_function	calcium ion binding
L	0005515	molecular_function	protein binding
L	0005543	molecular_function	phospholipid binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005634	cellular_component	nucleus
L	0005640	cellular_component	nuclear outer membrane
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005741	cellular_component	mitochondrial outer membrane
L	0005743	cellular_component	mitochondrial inner membrane
L	0005759	cellular_component	mitochondrial matrix
L	0005764	cellular_component	lysosome
L	0005829	cellular_component	cytosol
L	0005840	cellular_component	ribosome
L	0005856	cellular_component	cytoskeleton
L	0005886	cellular_component	plasma membrane
L	0005938	cellular_component	cell cortex
L	0006749	biological_process	glutathione metabolic process
L	0008017	molecular_function	microtubule binding
L	0008021	cellular_component	synaptic vesicle
L	0008047	molecular_function	enzyme activator activity
L	0008198	molecular_function	ferrous iron binding
L	0008270	molecular_function	zinc ion binding
L	0008289	molecular_function	lipid binding
L	0010040	biological_process	response to iron(II) ion
L	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
L	0014059	biological_process	regulation of dopamine secretion
L	0015629	cellular_component	actin cytoskeleton
L	0015631	molecular_function	tubulin binding
L	0016020	cellular_component	membrane
L	0016079	biological_process	synaptic vesicle exocytosis
L	0016082	biological_process	synaptic vesicle priming
L	0016234	cellular_component	inclusion body
L	0016491	molecular_function	oxidoreductase activity
L	0019894	molecular_function	kinesin binding
L	0019899	molecular_function	enzyme binding
L	0019904	molecular_function	protein domain specific binding
L	0030424	cellular_component	axon
L	0030426	cellular_component	growth cone
L	0030544	molecular_function	Hsp70 protein binding
L	0030659	cellular_component	cytoplasmic vesicle membrane
L	0030672	cellular_component	synaptic vesicle membrane
L	0031092	cellular_component	platelet alpha granule membrane
L	0031115	biological_process	negative regulation of microtubule polymerization
L	0031623	biological_process	receptor internalization
L	0031648	biological_process	protein destabilization
L	0032026	biological_process	response to magnesium ion
L	0032496	biological_process	response to lipopolysaccharide
L	0032991	cellular_component	protein-containing complex
L	0034341	biological_process	response to type II interferon
L	0034599	biological_process	cellular response to oxidative stress
L	0035493	biological_process	SNARE complex assembly
L	0035543	biological_process	positive regulation of SNARE complex assembly
L	0042220	biological_process	response to cocaine
L	0042393	molecular_function	histone binding
L	0042416	biological_process	dopamine biosynthetic process
L	0042802	molecular_function	identical protein binding
L	0043014	molecular_function	alpha-tubulin binding
L	0043025	cellular_component	neuronal cell body
L	0043065	biological_process	positive regulation of apoptotic process
L	0043066	biological_process	negative regulation of apoptotic process
L	0043195	cellular_component	terminal bouton
L	0043274	molecular_function	phospholipase binding
L	0043524	biological_process	negative regulation of neuron apoptotic process
L	0043679	cellular_component	axon terminus
L	0044344	biological_process	cellular response to fibroblast growth factor stimulus
L	0045202	cellular_component	synapse
L	0045807	biological_process	positive regulation of endocytosis
L	0045920	biological_process	negative regulation of exocytosis
L	0045921	biological_process	positive regulation of exocytosis
L	0045963	biological_process	negative regulation of dopamine metabolic process
L	0046872	molecular_function	metal ion binding
L	0048148	biological_process	behavioral response to cocaine
L	0048156	molecular_function	tau protein binding
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0048487	molecular_function	beta-tubulin binding
L	0048488	biological_process	synaptic vesicle endocytosis
L	0048489	biological_process	synaptic vesicle transport
L	0050729	biological_process	positive regulation of inflammatory response
L	0050808	biological_process	synapse organization
L	0051219	molecular_function	phosphoprotein binding
L	0051259	biological_process	protein complex oligomerization
L	0051262	biological_process	protein tetramerization
L	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
L	0051583	biological_process	dopamine uptake involved in synaptic transmission
L	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
L	0051612	biological_process	negative regulation of serotonin uptake
L	0051621	biological_process	regulation of norepinephrine uptake
L	0051622	biological_process	negative regulation of norepinephrine uptake
L	0055074	biological_process	calcium ion homeostasis
L	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
L	0060961	molecular_function	phospholipase D inhibitor activity
L	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
L	0070507	biological_process	regulation of microtubule cytoskeleton organization
L	0070555	biological_process	response to interleukin-1
L	0070840	molecular_function	dynein complex binding
L	0071280	biological_process	cellular response to copper ion
L	0071872	biological_process	cellular response to epinephrine stimulus
L	0097413	cellular_component	Lewy body
L	0097435	biological_process	supramolecular fiber organization
L	0098793	cellular_component	presynapse
L	0099512	cellular_component	supramolecular fiber
L	0140311	molecular_function	protein sequestering activity
L	0141108	molecular_function	transporter regulator activity
L	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
L	1903136	molecular_function	cuprous ion binding
L	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
L	1903421	biological_process	regulation of synaptic vesicle recycling
L	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
L	1904307	biological_process	response to desipramine
L	1904377	biological_process	positive regulation of protein localization to cell periphery
L	1904715	biological_process	negative regulation of chaperone-mediated autophagy
L	1905606	biological_process	regulation of presynapse assembly
L	1990000	biological_process	amyloid fibril formation
L	2000377	biological_process	regulation of reactive oxygen species metabolic process
M	0000122	biological_process	negative regulation of transcription by RNA polymerase II
M	0000149	molecular_function	SNARE binding
M	0000287	molecular_function	magnesium ion binding
M	0000976	molecular_function	transcription cis-regulatory region binding
M	0001774	biological_process	microglial cell activation
M	0001921	biological_process	positive regulation of receptor recycling
M	0001963	biological_process	synaptic transmission, dopaminergic
M	0003779	molecular_function	actin binding
M	0004857	molecular_function	enzyme inhibitor activity
M	0004860	molecular_function	protein kinase inhibitor activity
M	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
M	0005504	molecular_function	fatty acid binding
M	0005507	molecular_function	copper ion binding
M	0005509	molecular_function	calcium ion binding
M	0005515	molecular_function	protein binding
M	0005543	molecular_function	phospholipid binding
M	0005576	cellular_component	extracellular region
M	0005615	cellular_component	extracellular space
M	0005634	cellular_component	nucleus
M	0005640	cellular_component	nuclear outer membrane
M	0005737	cellular_component	cytoplasm
M	0005739	cellular_component	mitochondrion
M	0005741	cellular_component	mitochondrial outer membrane
M	0005743	cellular_component	mitochondrial inner membrane
M	0005759	cellular_component	mitochondrial matrix
M	0005764	cellular_component	lysosome
M	0005829	cellular_component	cytosol
M	0005840	cellular_component	ribosome
M	0005856	cellular_component	cytoskeleton
M	0005886	cellular_component	plasma membrane
M	0005938	cellular_component	cell cortex
M	0006749	biological_process	glutathione metabolic process
M	0008017	molecular_function	microtubule binding
M	0008021	cellular_component	synaptic vesicle
M	0008047	molecular_function	enzyme activator activity
M	0008198	molecular_function	ferrous iron binding
M	0008270	molecular_function	zinc ion binding
M	0008289	molecular_function	lipid binding
M	0010040	biological_process	response to iron(II) ion
M	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
M	0014059	biological_process	regulation of dopamine secretion
M	0015629	cellular_component	actin cytoskeleton
M	0015631	molecular_function	tubulin binding
M	0016020	cellular_component	membrane
M	0016079	biological_process	synaptic vesicle exocytosis
M	0016082	biological_process	synaptic vesicle priming
M	0016234	cellular_component	inclusion body
M	0016491	molecular_function	oxidoreductase activity
M	0019894	molecular_function	kinesin binding
M	0019899	molecular_function	enzyme binding
M	0019904	molecular_function	protein domain specific binding
M	0030424	cellular_component	axon
M	0030426	cellular_component	growth cone
M	0030544	molecular_function	Hsp70 protein binding
M	0030659	cellular_component	cytoplasmic vesicle membrane
M	0030672	cellular_component	synaptic vesicle membrane
M	0031092	cellular_component	platelet alpha granule membrane
M	0031115	biological_process	negative regulation of microtubule polymerization
M	0031623	biological_process	receptor internalization
M	0031648	biological_process	protein destabilization
M	0032026	biological_process	response to magnesium ion
M	0032496	biological_process	response to lipopolysaccharide
M	0032991	cellular_component	protein-containing complex
M	0034341	biological_process	response to type II interferon
M	0034599	biological_process	cellular response to oxidative stress
M	0035493	biological_process	SNARE complex assembly
M	0035543	biological_process	positive regulation of SNARE complex assembly
M	0042220	biological_process	response to cocaine
M	0042393	molecular_function	histone binding
M	0042416	biological_process	dopamine biosynthetic process
M	0042802	molecular_function	identical protein binding
M	0043014	molecular_function	alpha-tubulin binding
M	0043025	cellular_component	neuronal cell body
M	0043065	biological_process	positive regulation of apoptotic process
M	0043066	biological_process	negative regulation of apoptotic process
M	0043195	cellular_component	terminal bouton
M	0043274	molecular_function	phospholipase binding
M	0043524	biological_process	negative regulation of neuron apoptotic process
M	0043679	cellular_component	axon terminus
M	0044344	biological_process	cellular response to fibroblast growth factor stimulus
M	0045202	cellular_component	synapse
M	0045807	biological_process	positive regulation of endocytosis
M	0045920	biological_process	negative regulation of exocytosis
M	0045921	biological_process	positive regulation of exocytosis
M	0045963	biological_process	negative regulation of dopamine metabolic process
M	0046872	molecular_function	metal ion binding
M	0048148	biological_process	behavioral response to cocaine
M	0048156	molecular_function	tau protein binding
M	0048471	cellular_component	perinuclear region of cytoplasm
M	0048487	molecular_function	beta-tubulin binding
M	0048488	biological_process	synaptic vesicle endocytosis
M	0048489	biological_process	synaptic vesicle transport
M	0050729	biological_process	positive regulation of inflammatory response
M	0050808	biological_process	synapse organization
M	0051219	molecular_function	phosphoprotein binding
M	0051259	biological_process	protein complex oligomerization
M	0051262	biological_process	protein tetramerization
M	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
M	0051583	biological_process	dopamine uptake involved in synaptic transmission
M	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
M	0051612	biological_process	negative regulation of serotonin uptake
M	0051621	biological_process	regulation of norepinephrine uptake
M	0051622	biological_process	negative regulation of norepinephrine uptake
M	0055074	biological_process	calcium ion homeostasis
M	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
M	0060961	molecular_function	phospholipase D inhibitor activity
M	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
M	0070507	biological_process	regulation of microtubule cytoskeleton organization
M	0070555	biological_process	response to interleukin-1
M	0070840	molecular_function	dynein complex binding
M	0071280	biological_process	cellular response to copper ion
M	0071872	biological_process	cellular response to epinephrine stimulus
M	0097413	cellular_component	Lewy body
M	0097435	biological_process	supramolecular fiber organization
M	0098793	cellular_component	presynapse
M	0099512	cellular_component	supramolecular fiber
M	0140311	molecular_function	protein sequestering activity
M	0141108	molecular_function	transporter regulator activity
M	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
M	1903136	molecular_function	cuprous ion binding
M	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
M	1903421	biological_process	regulation of synaptic vesicle recycling
M	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
M	1904307	biological_process	response to desipramine
M	1904377	biological_process	positive regulation of protein localization to cell periphery
M	1904715	biological_process	negative regulation of chaperone-mediated autophagy
M	1905606	biological_process	regulation of presynapse assembly
M	1990000	biological_process	amyloid fibril formation
M	2000377	biological_process	regulation of reactive oxygen species metabolic process
N	0000122	biological_process	negative regulation of transcription by RNA polymerase II
N	0000149	molecular_function	SNARE binding
N	0000287	molecular_function	magnesium ion binding
N	0000976	molecular_function	transcription cis-regulatory region binding
N	0001774	biological_process	microglial cell activation
N	0001921	biological_process	positive regulation of receptor recycling
N	0001963	biological_process	synaptic transmission, dopaminergic
N	0003779	molecular_function	actin binding
N	0004857	molecular_function	enzyme inhibitor activity
N	0004860	molecular_function	protein kinase inhibitor activity
N	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
N	0005504	molecular_function	fatty acid binding
N	0005507	molecular_function	copper ion binding
N	0005509	molecular_function	calcium ion binding
N	0005515	molecular_function	protein binding
N	0005543	molecular_function	phospholipid binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005634	cellular_component	nucleus
N	0005640	cellular_component	nuclear outer membrane
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005741	cellular_component	mitochondrial outer membrane
N	0005743	cellular_component	mitochondrial inner membrane
N	0005759	cellular_component	mitochondrial matrix
N	0005764	cellular_component	lysosome
N	0005829	cellular_component	cytosol
N	0005840	cellular_component	ribosome
N	0005856	cellular_component	cytoskeleton
N	0005886	cellular_component	plasma membrane
N	0005938	cellular_component	cell cortex
N	0006749	biological_process	glutathione metabolic process
N	0008017	molecular_function	microtubule binding
N	0008021	cellular_component	synaptic vesicle
N	0008047	molecular_function	enzyme activator activity
N	0008198	molecular_function	ferrous iron binding
N	0008270	molecular_function	zinc ion binding
N	0008289	molecular_function	lipid binding
N	0010040	biological_process	response to iron(II) ion
N	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
N	0014059	biological_process	regulation of dopamine secretion
N	0015629	cellular_component	actin cytoskeleton
N	0015631	molecular_function	tubulin binding
N	0016020	cellular_component	membrane
N	0016079	biological_process	synaptic vesicle exocytosis
N	0016082	biological_process	synaptic vesicle priming
N	0016234	cellular_component	inclusion body
N	0016491	molecular_function	oxidoreductase activity
N	0019894	molecular_function	kinesin binding
N	0019899	molecular_function	enzyme binding
N	0019904	molecular_function	protein domain specific binding
N	0030424	cellular_component	axon
N	0030426	cellular_component	growth cone
N	0030544	molecular_function	Hsp70 protein binding
N	0030659	cellular_component	cytoplasmic vesicle membrane
N	0030672	cellular_component	synaptic vesicle membrane
N	0031092	cellular_component	platelet alpha granule membrane
N	0031115	biological_process	negative regulation of microtubule polymerization
N	0031623	biological_process	receptor internalization
N	0031648	biological_process	protein destabilization
N	0032026	biological_process	response to magnesium ion
N	0032496	biological_process	response to lipopolysaccharide
N	0032991	cellular_component	protein-containing complex
N	0034341	biological_process	response to type II interferon
N	0034599	biological_process	cellular response to oxidative stress
N	0035493	biological_process	SNARE complex assembly
N	0035543	biological_process	positive regulation of SNARE complex assembly
N	0042220	biological_process	response to cocaine
N	0042393	molecular_function	histone binding
N	0042416	biological_process	dopamine biosynthetic process
N	0042802	molecular_function	identical protein binding
N	0043014	molecular_function	alpha-tubulin binding
N	0043025	cellular_component	neuronal cell body
N	0043065	biological_process	positive regulation of apoptotic process
N	0043066	biological_process	negative regulation of apoptotic process
N	0043195	cellular_component	terminal bouton
N	0043274	molecular_function	phospholipase binding
N	0043524	biological_process	negative regulation of neuron apoptotic process
N	0043679	cellular_component	axon terminus
N	0044344	biological_process	cellular response to fibroblast growth factor stimulus
N	0045202	cellular_component	synapse
N	0045807	biological_process	positive regulation of endocytosis
N	0045920	biological_process	negative regulation of exocytosis
N	0045921	biological_process	positive regulation of exocytosis
N	0045963	biological_process	negative regulation of dopamine metabolic process
N	0046872	molecular_function	metal ion binding
N	0048148	biological_process	behavioral response to cocaine
N	0048156	molecular_function	tau protein binding
N	0048471	cellular_component	perinuclear region of cytoplasm
N	0048487	molecular_function	beta-tubulin binding
N	0048488	biological_process	synaptic vesicle endocytosis
N	0048489	biological_process	synaptic vesicle transport
N	0050729	biological_process	positive regulation of inflammatory response
N	0050808	biological_process	synapse organization
N	0051219	molecular_function	phosphoprotein binding
N	0051259	biological_process	protein complex oligomerization
N	0051262	biological_process	protein tetramerization
N	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
N	0051583	biological_process	dopamine uptake involved in synaptic transmission
N	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
N	0051612	biological_process	negative regulation of serotonin uptake
N	0051621	biological_process	regulation of norepinephrine uptake
N	0051622	biological_process	negative regulation of norepinephrine uptake
N	0055074	biological_process	calcium ion homeostasis
N	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
N	0060961	molecular_function	phospholipase D inhibitor activity
N	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
N	0070507	biological_process	regulation of microtubule cytoskeleton organization
N	0070555	biological_process	response to interleukin-1
N	0070840	molecular_function	dynein complex binding
N	0071280	biological_process	cellular response to copper ion
N	0071872	biological_process	cellular response to epinephrine stimulus
N	0097413	cellular_component	Lewy body
N	0097435	biological_process	supramolecular fiber organization
N	0098793	cellular_component	presynapse
N	0099512	cellular_component	supramolecular fiber
N	0140311	molecular_function	protein sequestering activity
N	0141108	molecular_function	transporter regulator activity
N	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
N	1903136	molecular_function	cuprous ion binding
N	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
N	1903421	biological_process	regulation of synaptic vesicle recycling
N	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
N	1904307	biological_process	response to desipramine
N	1904377	biological_process	positive regulation of protein localization to cell periphery
N	1904715	biological_process	negative regulation of chaperone-mediated autophagy
N	1905606	biological_process	regulation of presynapse assembly
N	1990000	biological_process	amyloid fibril formation
N	2000377	biological_process	regulation of reactive oxygen species metabolic process
O	0000122	biological_process	negative regulation of transcription by RNA polymerase II
O	0000149	molecular_function	SNARE binding
O	0000287	molecular_function	magnesium ion binding
O	0000976	molecular_function	transcription cis-regulatory region binding
O	0001774	biological_process	microglial cell activation
O	0001921	biological_process	positive regulation of receptor recycling
O	0001963	biological_process	synaptic transmission, dopaminergic
O	0003779	molecular_function	actin binding
O	0004857	molecular_function	enzyme inhibitor activity
O	0004860	molecular_function	protein kinase inhibitor activity
O	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
O	0005504	molecular_function	fatty acid binding
O	0005507	molecular_function	copper ion binding
O	0005509	molecular_function	calcium ion binding
O	0005515	molecular_function	protein binding
O	0005543	molecular_function	phospholipid binding
O	0005576	cellular_component	extracellular region
O	0005615	cellular_component	extracellular space
O	0005634	cellular_component	nucleus
O	0005640	cellular_component	nuclear outer membrane
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005741	cellular_component	mitochondrial outer membrane
O	0005743	cellular_component	mitochondrial inner membrane
O	0005759	cellular_component	mitochondrial matrix
O	0005764	cellular_component	lysosome
O	0005829	cellular_component	cytosol
O	0005840	cellular_component	ribosome
O	0005856	cellular_component	cytoskeleton
O	0005886	cellular_component	plasma membrane
O	0005938	cellular_component	cell cortex
O	0006749	biological_process	glutathione metabolic process
O	0008017	molecular_function	microtubule binding
O	0008021	cellular_component	synaptic vesicle
O	0008047	molecular_function	enzyme activator activity
O	0008198	molecular_function	ferrous iron binding
O	0008270	molecular_function	zinc ion binding
O	0008289	molecular_function	lipid binding
O	0010040	biological_process	response to iron(II) ion
O	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
O	0014059	biological_process	regulation of dopamine secretion
O	0015629	cellular_component	actin cytoskeleton
O	0015631	molecular_function	tubulin binding
O	0016020	cellular_component	membrane
O	0016079	biological_process	synaptic vesicle exocytosis
O	0016082	biological_process	synaptic vesicle priming
O	0016234	cellular_component	inclusion body
O	0016491	molecular_function	oxidoreductase activity
O	0019894	molecular_function	kinesin binding
O	0019899	molecular_function	enzyme binding
O	0019904	molecular_function	protein domain specific binding
O	0030424	cellular_component	axon
O	0030426	cellular_component	growth cone
O	0030544	molecular_function	Hsp70 protein binding
O	0030659	cellular_component	cytoplasmic vesicle membrane
O	0030672	cellular_component	synaptic vesicle membrane
O	0031092	cellular_component	platelet alpha granule membrane
O	0031115	biological_process	negative regulation of microtubule polymerization
O	0031623	biological_process	receptor internalization
O	0031648	biological_process	protein destabilization
O	0032026	biological_process	response to magnesium ion
O	0032496	biological_process	response to lipopolysaccharide
O	0032991	cellular_component	protein-containing complex
O	0034341	biological_process	response to type II interferon
O	0034599	biological_process	cellular response to oxidative stress
O	0035493	biological_process	SNARE complex assembly
O	0035543	biological_process	positive regulation of SNARE complex assembly
O	0042220	biological_process	response to cocaine
O	0042393	molecular_function	histone binding
O	0042416	biological_process	dopamine biosynthetic process
O	0042802	molecular_function	identical protein binding
O	0043014	molecular_function	alpha-tubulin binding
O	0043025	cellular_component	neuronal cell body
O	0043065	biological_process	positive regulation of apoptotic process
O	0043066	biological_process	negative regulation of apoptotic process
O	0043195	cellular_component	terminal bouton
O	0043274	molecular_function	phospholipase binding
O	0043524	biological_process	negative regulation of neuron apoptotic process
O	0043679	cellular_component	axon terminus
O	0044344	biological_process	cellular response to fibroblast growth factor stimulus
O	0045202	cellular_component	synapse
O	0045807	biological_process	positive regulation of endocytosis
O	0045920	biological_process	negative regulation of exocytosis
O	0045921	biological_process	positive regulation of exocytosis
O	0045963	biological_process	negative regulation of dopamine metabolic process
O	0046872	molecular_function	metal ion binding
O	0048148	biological_process	behavioral response to cocaine
O	0048156	molecular_function	tau protein binding
O	0048471	cellular_component	perinuclear region of cytoplasm
O	0048487	molecular_function	beta-tubulin binding
O	0048488	biological_process	synaptic vesicle endocytosis
O	0048489	biological_process	synaptic vesicle transport
O	0050729	biological_process	positive regulation of inflammatory response
O	0050808	biological_process	synapse organization
O	0051219	molecular_function	phosphoprotein binding
O	0051259	biological_process	protein complex oligomerization
O	0051262	biological_process	protein tetramerization
O	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
O	0051583	biological_process	dopamine uptake involved in synaptic transmission
O	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
O	0051612	biological_process	negative regulation of serotonin uptake
O	0051621	biological_process	regulation of norepinephrine uptake
O	0051622	biological_process	negative regulation of norepinephrine uptake
O	0055074	biological_process	calcium ion homeostasis
O	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
O	0060961	molecular_function	phospholipase D inhibitor activity
O	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
O	0070507	biological_process	regulation of microtubule cytoskeleton organization
O	0070555	biological_process	response to interleukin-1
O	0070840	molecular_function	dynein complex binding
O	0071280	biological_process	cellular response to copper ion
O	0071872	biological_process	cellular response to epinephrine stimulus
O	0097413	cellular_component	Lewy body
O	0097435	biological_process	supramolecular fiber organization
O	0098793	cellular_component	presynapse
O	0099512	cellular_component	supramolecular fiber
O	0140311	molecular_function	protein sequestering activity
O	0141108	molecular_function	transporter regulator activity
O	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
O	1903136	molecular_function	cuprous ion binding
O	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
O	1903421	biological_process	regulation of synaptic vesicle recycling
O	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
O	1904307	biological_process	response to desipramine
O	1904377	biological_process	positive regulation of protein localization to cell periphery
O	1904715	biological_process	negative regulation of chaperone-mediated autophagy
O	1905606	biological_process	regulation of presynapse assembly
O	1990000	biological_process	amyloid fibril formation
O	2000377	biological_process	regulation of reactive oxygen species metabolic process
P	0000122	biological_process	negative regulation of transcription by RNA polymerase II
P	0000149	molecular_function	SNARE binding
P	0000287	molecular_function	magnesium ion binding
P	0000976	molecular_function	transcription cis-regulatory region binding
P	0001774	biological_process	microglial cell activation
P	0001921	biological_process	positive regulation of receptor recycling
P	0001963	biological_process	synaptic transmission, dopaminergic
P	0003779	molecular_function	actin binding
P	0004857	molecular_function	enzyme inhibitor activity
P	0004860	molecular_function	protein kinase inhibitor activity
P	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
P	0005504	molecular_function	fatty acid binding
P	0005507	molecular_function	copper ion binding
P	0005509	molecular_function	calcium ion binding
P	0005515	molecular_function	protein binding
P	0005543	molecular_function	phospholipid binding
P	0005576	cellular_component	extracellular region
P	0005615	cellular_component	extracellular space
P	0005634	cellular_component	nucleus
P	0005640	cellular_component	nuclear outer membrane
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005741	cellular_component	mitochondrial outer membrane
P	0005743	cellular_component	mitochondrial inner membrane
P	0005759	cellular_component	mitochondrial matrix
P	0005764	cellular_component	lysosome
P	0005829	cellular_component	cytosol
P	0005840	cellular_component	ribosome
P	0005856	cellular_component	cytoskeleton
P	0005886	cellular_component	plasma membrane
P	0005938	cellular_component	cell cortex
P	0006749	biological_process	glutathione metabolic process
P	0008017	molecular_function	microtubule binding
P	0008021	cellular_component	synaptic vesicle
P	0008047	molecular_function	enzyme activator activity
P	0008198	molecular_function	ferrous iron binding
P	0008270	molecular_function	zinc ion binding
P	0008289	molecular_function	lipid binding
P	0010040	biological_process	response to iron(II) ion
P	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
P	0014059	biological_process	regulation of dopamine secretion
P	0015629	cellular_component	actin cytoskeleton
P	0015631	molecular_function	tubulin binding
P	0016020	cellular_component	membrane
P	0016079	biological_process	synaptic vesicle exocytosis
P	0016082	biological_process	synaptic vesicle priming
P	0016234	cellular_component	inclusion body
P	0016491	molecular_function	oxidoreductase activity
P	0019894	molecular_function	kinesin binding
P	0019899	molecular_function	enzyme binding
P	0019904	molecular_function	protein domain specific binding
P	0030424	cellular_component	axon
P	0030426	cellular_component	growth cone
P	0030544	molecular_function	Hsp70 protein binding
P	0030659	cellular_component	cytoplasmic vesicle membrane
P	0030672	cellular_component	synaptic vesicle membrane
P	0031092	cellular_component	platelet alpha granule membrane
P	0031115	biological_process	negative regulation of microtubule polymerization
P	0031623	biological_process	receptor internalization
P	0031648	biological_process	protein destabilization
P	0032026	biological_process	response to magnesium ion
P	0032496	biological_process	response to lipopolysaccharide
P	0032991	cellular_component	protein-containing complex
P	0034341	biological_process	response to type II interferon
P	0034599	biological_process	cellular response to oxidative stress
P	0035493	biological_process	SNARE complex assembly
P	0035543	biological_process	positive regulation of SNARE complex assembly
P	0042220	biological_process	response to cocaine
P	0042393	molecular_function	histone binding
P	0042416	biological_process	dopamine biosynthetic process
P	0042802	molecular_function	identical protein binding
P	0043014	molecular_function	alpha-tubulin binding
P	0043025	cellular_component	neuronal cell body
P	0043065	biological_process	positive regulation of apoptotic process
P	0043066	biological_process	negative regulation of apoptotic process
P	0043195	cellular_component	terminal bouton
P	0043274	molecular_function	phospholipase binding
P	0043524	biological_process	negative regulation of neuron apoptotic process
P	0043679	cellular_component	axon terminus
P	0044344	biological_process	cellular response to fibroblast growth factor stimulus
P	0045202	cellular_component	synapse
P	0045807	biological_process	positive regulation of endocytosis
P	0045920	biological_process	negative regulation of exocytosis
P	0045921	biological_process	positive regulation of exocytosis
P	0045963	biological_process	negative regulation of dopamine metabolic process
P	0046872	molecular_function	metal ion binding
P	0048148	biological_process	behavioral response to cocaine
P	0048156	molecular_function	tau protein binding
P	0048471	cellular_component	perinuclear region of cytoplasm
P	0048487	molecular_function	beta-tubulin binding
P	0048488	biological_process	synaptic vesicle endocytosis
P	0048489	biological_process	synaptic vesicle transport
P	0050729	biological_process	positive regulation of inflammatory response
P	0050808	biological_process	synapse organization
P	0051219	molecular_function	phosphoprotein binding
P	0051259	biological_process	protein complex oligomerization
P	0051262	biological_process	protein tetramerization
P	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
P	0051583	biological_process	dopamine uptake involved in synaptic transmission
P	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
P	0051612	biological_process	negative regulation of serotonin uptake
P	0051621	biological_process	regulation of norepinephrine uptake
P	0051622	biological_process	negative regulation of norepinephrine uptake
P	0055074	biological_process	calcium ion homeostasis
P	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
P	0060961	molecular_function	phospholipase D inhibitor activity
P	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
P	0070507	biological_process	regulation of microtubule cytoskeleton organization
P	0070555	biological_process	response to interleukin-1
P	0070840	molecular_function	dynein complex binding
P	0071280	biological_process	cellular response to copper ion
P	0071872	biological_process	cellular response to epinephrine stimulus
P	0097413	cellular_component	Lewy body
P	0097435	biological_process	supramolecular fiber organization
P	0098793	cellular_component	presynapse
P	0099512	cellular_component	supramolecular fiber
P	0140311	molecular_function	protein sequestering activity
P	0141108	molecular_function	transporter regulator activity
P	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
P	1903136	molecular_function	cuprous ion binding
P	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
P	1903421	biological_process	regulation of synaptic vesicle recycling
P	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
P	1904307	biological_process	response to desipramine
P	1904377	biological_process	positive regulation of protein localization to cell periphery
P	1904715	biological_process	negative regulation of chaperone-mediated autophagy
P	1905606	biological_process	regulation of presynapse assembly
P	1990000	biological_process	amyloid fibril formation
P	2000377	biological_process	regulation of reactive oxygen species metabolic process
Q	0000122	biological_process	negative regulation of transcription by RNA polymerase II
Q	0000149	molecular_function	SNARE binding
Q	0000287	molecular_function	magnesium ion binding
Q	0000976	molecular_function	transcription cis-regulatory region binding
Q	0001774	biological_process	microglial cell activation
Q	0001921	biological_process	positive regulation of receptor recycling
Q	0001963	biological_process	synaptic transmission, dopaminergic
Q	0003779	molecular_function	actin binding
Q	0004857	molecular_function	enzyme inhibitor activity
Q	0004860	molecular_function	protein kinase inhibitor activity
Q	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
Q	0005504	molecular_function	fatty acid binding
Q	0005507	molecular_function	copper ion binding
Q	0005509	molecular_function	calcium ion binding
Q	0005515	molecular_function	protein binding
Q	0005543	molecular_function	phospholipid binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005634	cellular_component	nucleus
Q	0005640	cellular_component	nuclear outer membrane
Q	0005737	cellular_component	cytoplasm
Q	0005739	cellular_component	mitochondrion
Q	0005741	cellular_component	mitochondrial outer membrane
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005759	cellular_component	mitochondrial matrix
Q	0005764	cellular_component	lysosome
Q	0005829	cellular_component	cytosol
Q	0005840	cellular_component	ribosome
Q	0005856	cellular_component	cytoskeleton
Q	0005886	cellular_component	plasma membrane
Q	0005938	cellular_component	cell cortex
Q	0006749	biological_process	glutathione metabolic process
Q	0008017	molecular_function	microtubule binding
Q	0008021	cellular_component	synaptic vesicle
Q	0008047	molecular_function	enzyme activator activity
Q	0008198	molecular_function	ferrous iron binding
Q	0008270	molecular_function	zinc ion binding
Q	0008289	molecular_function	lipid binding
Q	0010040	biological_process	response to iron(II) ion
Q	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
Q	0014059	biological_process	regulation of dopamine secretion
Q	0015629	cellular_component	actin cytoskeleton
Q	0015631	molecular_function	tubulin binding
Q	0016020	cellular_component	membrane
Q	0016079	biological_process	synaptic vesicle exocytosis
Q	0016082	biological_process	synaptic vesicle priming
Q	0016234	cellular_component	inclusion body
Q	0016491	molecular_function	oxidoreductase activity
Q	0019894	molecular_function	kinesin binding
Q	0019899	molecular_function	enzyme binding
Q	0019904	molecular_function	protein domain specific binding
Q	0030424	cellular_component	axon
Q	0030426	cellular_component	growth cone
Q	0030544	molecular_function	Hsp70 protein binding
Q	0030659	cellular_component	cytoplasmic vesicle membrane
Q	0030672	cellular_component	synaptic vesicle membrane
Q	0031092	cellular_component	platelet alpha granule membrane
Q	0031115	biological_process	negative regulation of microtubule polymerization
Q	0031623	biological_process	receptor internalization
Q	0031648	biological_process	protein destabilization
Q	0032026	biological_process	response to magnesium ion
Q	0032496	biological_process	response to lipopolysaccharide
Q	0032991	cellular_component	protein-containing complex
Q	0034341	biological_process	response to type II interferon
Q	0034599	biological_process	cellular response to oxidative stress
Q	0035493	biological_process	SNARE complex assembly
Q	0035543	biological_process	positive regulation of SNARE complex assembly
Q	0042220	biological_process	response to cocaine
Q	0042393	molecular_function	histone binding
Q	0042416	biological_process	dopamine biosynthetic process
Q	0042802	molecular_function	identical protein binding
Q	0043014	molecular_function	alpha-tubulin binding
Q	0043025	cellular_component	neuronal cell body
Q	0043065	biological_process	positive regulation of apoptotic process
Q	0043066	biological_process	negative regulation of apoptotic process
Q	0043195	cellular_component	terminal bouton
Q	0043274	molecular_function	phospholipase binding
Q	0043524	biological_process	negative regulation of neuron apoptotic process
Q	0043679	cellular_component	axon terminus
Q	0044344	biological_process	cellular response to fibroblast growth factor stimulus
Q	0045202	cellular_component	synapse
Q	0045807	biological_process	positive regulation of endocytosis
Q	0045920	biological_process	negative regulation of exocytosis
Q	0045921	biological_process	positive regulation of exocytosis
Q	0045963	biological_process	negative regulation of dopamine metabolic process
Q	0046872	molecular_function	metal ion binding
Q	0048148	biological_process	behavioral response to cocaine
Q	0048156	molecular_function	tau protein binding
Q	0048471	cellular_component	perinuclear region of cytoplasm
Q	0048487	molecular_function	beta-tubulin binding
Q	0048488	biological_process	synaptic vesicle endocytosis
Q	0048489	biological_process	synaptic vesicle transport
Q	0050729	biological_process	positive regulation of inflammatory response
Q	0050808	biological_process	synapse organization
Q	0051219	molecular_function	phosphoprotein binding
Q	0051259	biological_process	protein complex oligomerization
Q	0051262	biological_process	protein tetramerization
Q	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
Q	0051583	biological_process	dopamine uptake involved in synaptic transmission
Q	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
Q	0051612	biological_process	negative regulation of serotonin uptake
Q	0051621	biological_process	regulation of norepinephrine uptake
Q	0051622	biological_process	negative regulation of norepinephrine uptake
Q	0055074	biological_process	calcium ion homeostasis
Q	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
Q	0060961	molecular_function	phospholipase D inhibitor activity
Q	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
Q	0070507	biological_process	regulation of microtubule cytoskeleton organization
Q	0070555	biological_process	response to interleukin-1
Q	0070840	molecular_function	dynein complex binding
Q	0071280	biological_process	cellular response to copper ion
Q	0071872	biological_process	cellular response to epinephrine stimulus
Q	0097413	cellular_component	Lewy body
Q	0097435	biological_process	supramolecular fiber organization
Q	0098793	cellular_component	presynapse
Q	0099512	cellular_component	supramolecular fiber
Q	0140311	molecular_function	protein sequestering activity
Q	0141108	molecular_function	transporter regulator activity
Q	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
Q	1903136	molecular_function	cuprous ion binding
Q	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
Q	1903421	biological_process	regulation of synaptic vesicle recycling
Q	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
Q	1904307	biological_process	response to desipramine
Q	1904377	biological_process	positive regulation of protein localization to cell periphery
Q	1904715	biological_process	negative regulation of chaperone-mediated autophagy
Q	1905606	biological_process	regulation of presynapse assembly
Q	1990000	biological_process	amyloid fibril formation
Q	2000377	biological_process	regulation of reactive oxygen species metabolic process
R	0000122	biological_process	negative regulation of transcription by RNA polymerase II
R	0000149	molecular_function	SNARE binding
R	0000287	molecular_function	magnesium ion binding
R	0000976	molecular_function	transcription cis-regulatory region binding
R	0001774	biological_process	microglial cell activation
R	0001921	biological_process	positive regulation of receptor recycling
R	0001963	biological_process	synaptic transmission, dopaminergic
R	0003779	molecular_function	actin binding
R	0004857	molecular_function	enzyme inhibitor activity
R	0004860	molecular_function	protein kinase inhibitor activity
R	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
R	0005504	molecular_function	fatty acid binding
R	0005507	molecular_function	copper ion binding
R	0005509	molecular_function	calcium ion binding
R	0005515	molecular_function	protein binding
R	0005543	molecular_function	phospholipid binding
R	0005576	cellular_component	extracellular region
R	0005615	cellular_component	extracellular space
R	0005634	cellular_component	nucleus
R	0005640	cellular_component	nuclear outer membrane
R	0005737	cellular_component	cytoplasm
R	0005739	cellular_component	mitochondrion
R	0005741	cellular_component	mitochondrial outer membrane
R	0005743	cellular_component	mitochondrial inner membrane
R	0005759	cellular_component	mitochondrial matrix
R	0005764	cellular_component	lysosome
R	0005829	cellular_component	cytosol
R	0005840	cellular_component	ribosome
R	0005856	cellular_component	cytoskeleton
R	0005886	cellular_component	plasma membrane
R	0005938	cellular_component	cell cortex
R	0006749	biological_process	glutathione metabolic process
R	0008017	molecular_function	microtubule binding
R	0008021	cellular_component	synaptic vesicle
R	0008047	molecular_function	enzyme activator activity
R	0008198	molecular_function	ferrous iron binding
R	0008270	molecular_function	zinc ion binding
R	0008289	molecular_function	lipid binding
R	0010040	biological_process	response to iron(II) ion
R	0010642	biological_process	negative regulation of platelet-derived growth factor receptor signaling pathway
R	0014059	biological_process	regulation of dopamine secretion
R	0015629	cellular_component	actin cytoskeleton
R	0015631	molecular_function	tubulin binding
R	0016020	cellular_component	membrane
R	0016079	biological_process	synaptic vesicle exocytosis
R	0016082	biological_process	synaptic vesicle priming
R	0016234	cellular_component	inclusion body
R	0016491	molecular_function	oxidoreductase activity
R	0019894	molecular_function	kinesin binding
R	0019899	molecular_function	enzyme binding
R	0019904	molecular_function	protein domain specific binding
R	0030424	cellular_component	axon
R	0030426	cellular_component	growth cone
R	0030544	molecular_function	Hsp70 protein binding
R	0030659	cellular_component	cytoplasmic vesicle membrane
R	0030672	cellular_component	synaptic vesicle membrane
R	0031092	cellular_component	platelet alpha granule membrane
R	0031115	biological_process	negative regulation of microtubule polymerization
R	0031623	biological_process	receptor internalization
R	0031648	biological_process	protein destabilization
R	0032026	biological_process	response to magnesium ion
R	0032496	biological_process	response to lipopolysaccharide
R	0032991	cellular_component	protein-containing complex
R	0034341	biological_process	response to type II interferon
R	0034599	biological_process	cellular response to oxidative stress
R	0035493	biological_process	SNARE complex assembly
R	0035543	biological_process	positive regulation of SNARE complex assembly
R	0042220	biological_process	response to cocaine
R	0042393	molecular_function	histone binding
R	0042416	biological_process	dopamine biosynthetic process
R	0042802	molecular_function	identical protein binding
R	0043014	molecular_function	alpha-tubulin binding
R	0043025	cellular_component	neuronal cell body
R	0043065	biological_process	positive regulation of apoptotic process
R	0043066	biological_process	negative regulation of apoptotic process
R	0043195	cellular_component	terminal bouton
R	0043274	molecular_function	phospholipase binding
R	0043524	biological_process	negative regulation of neuron apoptotic process
R	0043679	cellular_component	axon terminus
R	0044344	biological_process	cellular response to fibroblast growth factor stimulus
R	0045202	cellular_component	synapse
R	0045807	biological_process	positive regulation of endocytosis
R	0045920	biological_process	negative regulation of exocytosis
R	0045921	biological_process	positive regulation of exocytosis
R	0045963	biological_process	negative regulation of dopamine metabolic process
R	0046872	molecular_function	metal ion binding
R	0048148	biological_process	behavioral response to cocaine
R	0048156	molecular_function	tau protein binding
R	0048471	cellular_component	perinuclear region of cytoplasm
R	0048487	molecular_function	beta-tubulin binding
R	0048488	biological_process	synaptic vesicle endocytosis
R	0048489	biological_process	synaptic vesicle transport
R	0050729	biological_process	positive regulation of inflammatory response
R	0050808	biological_process	synapse organization
R	0051219	molecular_function	phosphoprotein binding
R	0051259	biological_process	protein complex oligomerization
R	0051262	biological_process	protein tetramerization
R	0051281	biological_process	positive regulation of release of sequestered calcium ion into cytosol
R	0051583	biological_process	dopamine uptake involved in synaptic transmission
R	0051585	biological_process	negative regulation of dopamine uptake involved in synaptic transmission
R	0051612	biological_process	negative regulation of serotonin uptake
R	0051621	biological_process	regulation of norepinephrine uptake
R	0051622	biological_process	negative regulation of norepinephrine uptake
R	0055074	biological_process	calcium ion homeostasis
R	0060732	biological_process	positive regulation of inositol phosphate biosynthetic process
R	0060961	molecular_function	phospholipase D inhibitor activity
R	0070495	biological_process	negative regulation of thrombin-activated receptor signaling pathway
R	0070507	biological_process	regulation of microtubule cytoskeleton organization
R	0070555	biological_process	response to interleukin-1
R	0070840	molecular_function	dynein complex binding
R	0071280	biological_process	cellular response to copper ion
R	0071872	biological_process	cellular response to epinephrine stimulus
R	0097413	cellular_component	Lewy body
R	0097435	biological_process	supramolecular fiber organization
R	0098793	cellular_component	presynapse
R	0099512	cellular_component	supramolecular fiber
R	0140311	molecular_function	protein sequestering activity
R	0141108	molecular_function	transporter regulator activity
R	1902957	biological_process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
R	1903136	molecular_function	cuprous ion binding
R	1903285	biological_process	positive regulation of hydrogen peroxide catabolic process
R	1903421	biological_process	regulation of synaptic vesicle recycling
R	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
R	1904307	biological_process	response to desipramine
R	1904377	biological_process	positive regulation of protein localization to cell periphery
R	1904715	biological_process	negative regulation of chaperone-mediated autophagy
R	1905606	biological_process	regulation of presynapse assembly
R	1990000	biological_process	amyloid fibril formation
R	2000377	biological_process	regulation of reactive oxygen species metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Repeat: {"description":"3; approximate"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	100
Details	Repeat: {"description":"4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"10617630","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---