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9FYP

Cryo EM structure of the type 3B polymorph of alpha-synuclein at low pH.

Replaces:  8PIC
Functional Information from GO Data
ChainGOidnamespacecontents
I0098794cellular_componentpostsynapse
I0034599biological_processcellular response to oxidative stress
I0050808biological_processsynapse organization
I0007268biological_processchemical synaptic transmission
I0043025cellular_componentneuronal cell body
I0005737cellular_componentcytoplasm
I0048488biological_processsynaptic vesicle endocytosis
I0043679cellular_componentaxon terminus
I1903136molecular_functioncuprous ion binding
I0016020cellular_componentmembrane
I0046872molecular_functionmetal ion binding
I0005634cellular_componentnucleus
I0045202cellular_componentsynapse
I0005576cellular_componentextracellular region
I0042995cellular_componentcell projection
I0030424cellular_componentaxon
I0005515molecular_functionprotein binding
I0033138biological_processpositive regulation of peptidyl-serine phosphorylation
I0001774biological_processmicroglial cell activation
I0001956biological_processpositive regulation of neurotransmitter secretion
I0001963biological_processsynaptic transmission, dopaminergic
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
I0005886cellular_componentplasma membrane
I0006631biological_processfatty acid metabolic process
I0006638biological_processneutral lipid metabolic process
I0006644biological_processphospholipid metabolic process
I0007006biological_processmitochondrial membrane organization
I0007269biological_processneurotransmitter secretion
I0008344biological_processadult locomotory behavior
I0009410biological_processresponse to xenobiotic stimulus
I0014048biological_processregulation of glutamate secretion
I0014059biological_processregulation of dopamine secretion
I0016234cellular_componentinclusion body
I0030672cellular_componentsynaptic vesicle membrane
I0035493biological_processSNARE complex assembly
I0040012biological_processregulation of locomotion
I0042393molecular_functionhistone binding
I0042416biological_processdopamine biosynthetic process
I0042417biological_processdopamine metabolic process
I0042775biological_processmitochondrial ATP synthesis coupled electron transport
I0042802molecular_functionidentical protein binding
I0043030biological_processregulation of macrophage activation
I0043524biological_processnegative regulation of neuron apoptotic process
I0046928biological_processregulation of neurotransmitter secretion
I0048168biological_processregulation of neuronal synaptic plasticity
I0048169biological_processregulation of long-term neuronal synaptic plasticity
I0048489biological_processsynaptic vesicle transport
I0050806biological_processpositive regulation of synaptic transmission
I0050812biological_processregulation of acyl-CoA biosynthetic process
I0051259biological_processprotein complex oligomerization
I0051402biological_processneuron apoptotic process
I0060079biological_processexcitatory postsynaptic potential
I0060291biological_processlong-term synaptic potentiation
I0061024biological_processmembrane organization
I2000377biological_processregulation of reactive oxygen species metabolic process
I0030544molecular_functionHsp70 protein binding
I0022898biological_processregulation of transmembrane transporter activity
I0051621biological_processregulation of norepinephrine uptake
I0003779molecular_functionactin binding
I0043014molecular_functionalpha-tubulin binding
I1904377biological_processpositive regulation of protein localization to cell periphery
I1905606biological_processregulation of presynapse assembly
I0019894molecular_functionkinesin binding
I0070840molecular_functiondynein complex binding
I0008289molecular_functionlipid binding
I0060090molecular_functionmolecular adaptor activity
I1990000biological_processamyloid fibril formation
I0000149molecular_functionSNARE binding
I0000287molecular_functionmagnesium ion binding
I0001921biological_processpositive regulation of receptor recycling
I0005504molecular_functionfatty acid binding
I0005507molecular_functioncopper ion binding
I0005509molecular_functioncalcium ion binding
I0005543molecular_functionphospholipid binding
I0005615cellular_componentextracellular space
I0005938cellular_componentcell cortex
I0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
I0008198molecular_functionferrous iron binding
I0008270molecular_functionzinc ion binding
I0010040biological_processresponse to iron(II) ion
I0010517biological_processregulation of phospholipase activity
I0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
I0015629cellular_componentactin cytoskeleton
I0016079biological_processsynaptic vesicle exocytosis
I0016491molecular_functionoxidoreductase activity
I0030426cellular_componentgrowth cone
I0031092cellular_componentplatelet alpha granule membrane
I0031115biological_processnegative regulation of microtubule polymerization
I0031623biological_processreceptor internalization
I0031648biological_processprotein destabilization
I0032026biological_processresponse to magnesium ion
I0032410biological_processnegative regulation of transporter activity
I0032496biological_processresponse to lipopolysaccharide
I0032769biological_processnegative regulation of monooxygenase activity
I0034341biological_processresponse to type II interferon
I0035543biological_processpositive regulation of SNARE complex assembly
I0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
I0045807biological_processpositive regulation of endocytosis
I0048156molecular_functiontau protein binding
I0048471cellular_componentperinuclear region of cytoplasm
I0050729biological_processpositive regulation of inflammatory response
I0051219molecular_functionphosphoprotein binding
I0051262biological_processprotein tetramerization
I0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
I0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
I0051612biological_processnegative regulation of serotonin uptake
I0051622biological_processnegative regulation of norepinephrine uptake
I0055074biological_processcalcium ion homeostasis
I0060732biological_processpositive regulation of inositol phosphate biosynthetic process
I0060961molecular_functionphospholipase D inhibitor activity
I0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
I0070555biological_processresponse to interleukin-1
I0071280biological_processcellular response to copper ion
I0071902biological_processpositive regulation of protein serine/threonine kinase activity
I0099512cellular_componentsupramolecular fiber
I1903284biological_processpositive regulation of glutathione peroxidase activity
I1903285biological_processpositive regulation of hydrogen peroxide catabolic process
I0016082biological_processsynaptic vesicle priming
I0032991cellular_componentprotein-containing complex
I0043066biological_processnegative regulation of apoptotic process
I0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
I0045920biological_processnegative regulation of exocytosis
I0045921biological_processpositive regulation of exocytosis
I1904715biological_processnegative regulation of chaperone-mediated autophagy
I0000122biological_processnegative regulation of transcription by RNA polymerase II
I0000976molecular_functiontranscription cis-regulatory region binding
I0004860molecular_functionprotein kinase inhibitor activity
I0005739cellular_componentmitochondrion
I0005764cellular_componentlysosome
I0006469biological_processnegative regulation of protein kinase activity
I0043065biological_processpositive regulation of apoptotic process
I0051583biological_processdopamine uptake involved in synaptic transmission
I0071872biological_processcellular response to epinephrine stimulus
I0097435biological_processsupramolecular fiber organization
I1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
I1903421biological_processregulation of synaptic vesicle recycling
I1903426biological_processregulation of reactive oxygen species biosynthetic process
J0098794cellular_componentpostsynapse
J0034599biological_processcellular response to oxidative stress
J0050808biological_processsynapse organization
J0007268biological_processchemical synaptic transmission
J0043025cellular_componentneuronal cell body
J0005737cellular_componentcytoplasm
J0048488biological_processsynaptic vesicle endocytosis
J0043679cellular_componentaxon terminus
J1903136molecular_functioncuprous ion binding
J0016020cellular_componentmembrane
J0046872molecular_functionmetal ion binding
J0005634cellular_componentnucleus
J0045202cellular_componentsynapse
J0005576cellular_componentextracellular region
J0042995cellular_componentcell projection
J0030424cellular_componentaxon
J0005515molecular_functionprotein binding
J0033138biological_processpositive regulation of peptidyl-serine phosphorylation
J0001774biological_processmicroglial cell activation
J0001956biological_processpositive regulation of neurotransmitter secretion
J0001963biological_processsynaptic transmission, dopaminergic
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005886cellular_componentplasma membrane
J0006631biological_processfatty acid metabolic process
J0006638biological_processneutral lipid metabolic process
J0006644biological_processphospholipid metabolic process
J0007006biological_processmitochondrial membrane organization
J0007269biological_processneurotransmitter secretion
J0008344biological_processadult locomotory behavior
J0009410biological_processresponse to xenobiotic stimulus
J0014048biological_processregulation of glutamate secretion
J0014059biological_processregulation of dopamine secretion
J0016234cellular_componentinclusion body
J0030672cellular_componentsynaptic vesicle membrane
J0035493biological_processSNARE complex assembly
J0040012biological_processregulation of locomotion
J0042393molecular_functionhistone binding
J0042416biological_processdopamine biosynthetic process
J0042417biological_processdopamine metabolic process
J0042775biological_processmitochondrial ATP synthesis coupled electron transport
J0042802molecular_functionidentical protein binding
J0043030biological_processregulation of macrophage activation
J0043524biological_processnegative regulation of neuron apoptotic process
J0046928biological_processregulation of neurotransmitter secretion
J0048168biological_processregulation of neuronal synaptic plasticity
J0048169biological_processregulation of long-term neuronal synaptic plasticity
J0048489biological_processsynaptic vesicle transport
J0050806biological_processpositive regulation of synaptic transmission
J0050812biological_processregulation of acyl-CoA biosynthetic process
J0051259biological_processprotein complex oligomerization
J0051402biological_processneuron apoptotic process
J0060079biological_processexcitatory postsynaptic potential
J0060291biological_processlong-term synaptic potentiation
J0061024biological_processmembrane organization
J2000377biological_processregulation of reactive oxygen species metabolic process
J0030544molecular_functionHsp70 protein binding
J0022898biological_processregulation of transmembrane transporter activity
J0051621biological_processregulation of norepinephrine uptake
J0003779molecular_functionactin binding
J0043014molecular_functionalpha-tubulin binding
J1904377biological_processpositive regulation of protein localization to cell periphery
J1905606biological_processregulation of presynapse assembly
J0019894molecular_functionkinesin binding
J0070840molecular_functiondynein complex binding
J0008289molecular_functionlipid binding
J0060090molecular_functionmolecular adaptor activity
J1990000biological_processamyloid fibril formation
J0000149molecular_functionSNARE binding
J0000287molecular_functionmagnesium ion binding
J0001921biological_processpositive regulation of receptor recycling
J0005504molecular_functionfatty acid binding
J0005507molecular_functioncopper ion binding
J0005509molecular_functioncalcium ion binding
J0005543molecular_functionphospholipid binding
J0005615cellular_componentextracellular space
J0005938cellular_componentcell cortex
J0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
J0008198molecular_functionferrous iron binding
J0008270molecular_functionzinc ion binding
J0010040biological_processresponse to iron(II) ion
J0010517biological_processregulation of phospholipase activity
J0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
J0015629cellular_componentactin cytoskeleton
J0016079biological_processsynaptic vesicle exocytosis
J0016491molecular_functionoxidoreductase activity
J0030426cellular_componentgrowth cone
J0031092cellular_componentplatelet alpha granule membrane
J0031115biological_processnegative regulation of microtubule polymerization
J0031623biological_processreceptor internalization
J0031648biological_processprotein destabilization
J0032026biological_processresponse to magnesium ion
J0032410biological_processnegative regulation of transporter activity
J0032496biological_processresponse to lipopolysaccharide
J0032769biological_processnegative regulation of monooxygenase activity
J0034341biological_processresponse to type II interferon
J0035543biological_processpositive regulation of SNARE complex assembly
J0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
J0045807biological_processpositive regulation of endocytosis
J0048156molecular_functiontau protein binding
J0048471cellular_componentperinuclear region of cytoplasm
J0050729biological_processpositive regulation of inflammatory response
J0051219molecular_functionphosphoprotein binding
J0051262biological_processprotein tetramerization
J0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
J0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
J0051612biological_processnegative regulation of serotonin uptake
J0051622biological_processnegative regulation of norepinephrine uptake
J0055074biological_processcalcium ion homeostasis
J0060732biological_processpositive regulation of inositol phosphate biosynthetic process
J0060961molecular_functionphospholipase D inhibitor activity
J0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
J0070555biological_processresponse to interleukin-1
J0071280biological_processcellular response to copper ion
J0071902biological_processpositive regulation of protein serine/threonine kinase activity
J0099512cellular_componentsupramolecular fiber
J1903284biological_processpositive regulation of glutathione peroxidase activity
J1903285biological_processpositive regulation of hydrogen peroxide catabolic process
J0016082biological_processsynaptic vesicle priming
J0032991cellular_componentprotein-containing complex
J0043066biological_processnegative regulation of apoptotic process
J0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
J0045920biological_processnegative regulation of exocytosis
J0045921biological_processpositive regulation of exocytosis
J1904715biological_processnegative regulation of chaperone-mediated autophagy
J0000122biological_processnegative regulation of transcription by RNA polymerase II
J0000976molecular_functiontranscription cis-regulatory region binding
J0004860molecular_functionprotein kinase inhibitor activity
J0005739cellular_componentmitochondrion
J0005764cellular_componentlysosome
J0006469biological_processnegative regulation of protein kinase activity
J0043065biological_processpositive regulation of apoptotic process
J0051583biological_processdopamine uptake involved in synaptic transmission
J0071872biological_processcellular response to epinephrine stimulus
J0097435biological_processsupramolecular fiber organization
J1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
J1903421biological_processregulation of synaptic vesicle recycling
J1903426biological_processregulation of reactive oxygen species biosynthetic process
K0098794cellular_componentpostsynapse
K0034599biological_processcellular response to oxidative stress
K0050808biological_processsynapse organization
K0007268biological_processchemical synaptic transmission
K0043025cellular_componentneuronal cell body
K0005737cellular_componentcytoplasm
K0048488biological_processsynaptic vesicle endocytosis
K0043679cellular_componentaxon terminus
K1903136molecular_functioncuprous ion binding
K0016020cellular_componentmembrane
K0046872molecular_functionmetal ion binding
K0005634cellular_componentnucleus
K0045202cellular_componentsynapse
K0005576cellular_componentextracellular region
K0042995cellular_componentcell projection
K0030424cellular_componentaxon
K0005515molecular_functionprotein binding
K0033138biological_processpositive regulation of peptidyl-serine phosphorylation
K0001774biological_processmicroglial cell activation
K0001956biological_processpositive regulation of neurotransmitter secretion
K0001963biological_processsynaptic transmission, dopaminergic
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005886cellular_componentplasma membrane
K0006631biological_processfatty acid metabolic process
K0006638biological_processneutral lipid metabolic process
K0006644biological_processphospholipid metabolic process
K0007006biological_processmitochondrial membrane organization
K0007269biological_processneurotransmitter secretion
K0008344biological_processadult locomotory behavior
K0009410biological_processresponse to xenobiotic stimulus
K0014048biological_processregulation of glutamate secretion
K0014059biological_processregulation of dopamine secretion
K0016234cellular_componentinclusion body
K0030672cellular_componentsynaptic vesicle membrane
K0035493biological_processSNARE complex assembly
K0040012biological_processregulation of locomotion
K0042393molecular_functionhistone binding
K0042416biological_processdopamine biosynthetic process
K0042417biological_processdopamine metabolic process
K0042775biological_processmitochondrial ATP synthesis coupled electron transport
K0042802molecular_functionidentical protein binding
K0043030biological_processregulation of macrophage activation
K0043524biological_processnegative regulation of neuron apoptotic process
K0046928biological_processregulation of neurotransmitter secretion
K0048168biological_processregulation of neuronal synaptic plasticity
K0048169biological_processregulation of long-term neuronal synaptic plasticity
K0048489biological_processsynaptic vesicle transport
K0050806biological_processpositive regulation of synaptic transmission
K0050812biological_processregulation of acyl-CoA biosynthetic process
K0051259biological_processprotein complex oligomerization
K0051402biological_processneuron apoptotic process
K0060079biological_processexcitatory postsynaptic potential
K0060291biological_processlong-term synaptic potentiation
K0061024biological_processmembrane organization
K2000377biological_processregulation of reactive oxygen species metabolic process
K0030544molecular_functionHsp70 protein binding
K0022898biological_processregulation of transmembrane transporter activity
K0051621biological_processregulation of norepinephrine uptake
K0003779molecular_functionactin binding
K0043014molecular_functionalpha-tubulin binding
K1904377biological_processpositive regulation of protein localization to cell periphery
K1905606biological_processregulation of presynapse assembly
K0019894molecular_functionkinesin binding
K0070840molecular_functiondynein complex binding
K0008289molecular_functionlipid binding
K0060090molecular_functionmolecular adaptor activity
K1990000biological_processamyloid fibril formation
K0000149molecular_functionSNARE binding
K0000287molecular_functionmagnesium ion binding
K0001921biological_processpositive regulation of receptor recycling
K0005504molecular_functionfatty acid binding
K0005507molecular_functioncopper ion binding
K0005509molecular_functioncalcium ion binding
K0005543molecular_functionphospholipid binding
K0005615cellular_componentextracellular space
K0005938cellular_componentcell cortex
K0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
K0008198molecular_functionferrous iron binding
K0008270molecular_functionzinc ion binding
K0010040biological_processresponse to iron(II) ion
K0010517biological_processregulation of phospholipase activity
K0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
K0015629cellular_componentactin cytoskeleton
K0016079biological_processsynaptic vesicle exocytosis
K0016491molecular_functionoxidoreductase activity
K0030426cellular_componentgrowth cone
K0031092cellular_componentplatelet alpha granule membrane
K0031115biological_processnegative regulation of microtubule polymerization
K0031623biological_processreceptor internalization
K0031648biological_processprotein destabilization
K0032026biological_processresponse to magnesium ion
K0032410biological_processnegative regulation of transporter activity
K0032496biological_processresponse to lipopolysaccharide
K0032769biological_processnegative regulation of monooxygenase activity
K0034341biological_processresponse to type II interferon
K0035543biological_processpositive regulation of SNARE complex assembly
K0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
K0045807biological_processpositive regulation of endocytosis
K0048156molecular_functiontau protein binding
K0048471cellular_componentperinuclear region of cytoplasm
K0050729biological_processpositive regulation of inflammatory response
K0051219molecular_functionphosphoprotein binding
K0051262biological_processprotein tetramerization
K0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
K0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
K0051612biological_processnegative regulation of serotonin uptake
K0051622biological_processnegative regulation of norepinephrine uptake
K0055074biological_processcalcium ion homeostasis
K0060732biological_processpositive regulation of inositol phosphate biosynthetic process
K0060961molecular_functionphospholipase D inhibitor activity
K0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
K0070555biological_processresponse to interleukin-1
K0071280biological_processcellular response to copper ion
K0071902biological_processpositive regulation of protein serine/threonine kinase activity
K0099512cellular_componentsupramolecular fiber
K1903284biological_processpositive regulation of glutathione peroxidase activity
K1903285biological_processpositive regulation of hydrogen peroxide catabolic process
K0016082biological_processsynaptic vesicle priming
K0032991cellular_componentprotein-containing complex
K0043066biological_processnegative regulation of apoptotic process
K0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
K0045920biological_processnegative regulation of exocytosis
K0045921biological_processpositive regulation of exocytosis
K1904715biological_processnegative regulation of chaperone-mediated autophagy
K0000122biological_processnegative regulation of transcription by RNA polymerase II
K0000976molecular_functiontranscription cis-regulatory region binding
K0004860molecular_functionprotein kinase inhibitor activity
K0005739cellular_componentmitochondrion
K0005764cellular_componentlysosome
K0006469biological_processnegative regulation of protein kinase activity
K0043065biological_processpositive regulation of apoptotic process
K0051583biological_processdopamine uptake involved in synaptic transmission
K0071872biological_processcellular response to epinephrine stimulus
K0097435biological_processsupramolecular fiber organization
K1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
K1903421biological_processregulation of synaptic vesicle recycling
K1903426biological_processregulation of reactive oxygen species biosynthetic process
L0098794cellular_componentpostsynapse
L0034599biological_processcellular response to oxidative stress
L0050808biological_processsynapse organization
L0007268biological_processchemical synaptic transmission
L0043025cellular_componentneuronal cell body
L0005737cellular_componentcytoplasm
L0048488biological_processsynaptic vesicle endocytosis
L0043679cellular_componentaxon terminus
L1903136molecular_functioncuprous ion binding
L0016020cellular_componentmembrane
L0046872molecular_functionmetal ion binding
L0005634cellular_componentnucleus
L0045202cellular_componentsynapse
L0005576cellular_componentextracellular region
L0042995cellular_componentcell projection
L0030424cellular_componentaxon
L0005515molecular_functionprotein binding
L0033138biological_processpositive regulation of peptidyl-serine phosphorylation
L0001774biological_processmicroglial cell activation
L0001956biological_processpositive regulation of neurotransmitter secretion
L0001963biological_processsynaptic transmission, dopaminergic
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0005886cellular_componentplasma membrane
L0006631biological_processfatty acid metabolic process
L0006638biological_processneutral lipid metabolic process
L0006644biological_processphospholipid metabolic process
L0007006biological_processmitochondrial membrane organization
L0007269biological_processneurotransmitter secretion
L0008344biological_processadult locomotory behavior
L0009410biological_processresponse to xenobiotic stimulus
L0014048biological_processregulation of glutamate secretion
L0014059biological_processregulation of dopamine secretion
L0016234cellular_componentinclusion body
L0030672cellular_componentsynaptic vesicle membrane
L0035493biological_processSNARE complex assembly
L0040012biological_processregulation of locomotion
L0042393molecular_functionhistone binding
L0042416biological_processdopamine biosynthetic process
L0042417biological_processdopamine metabolic process
L0042775biological_processmitochondrial ATP synthesis coupled electron transport
L0042802molecular_functionidentical protein binding
L0043030biological_processregulation of macrophage activation
L0043524biological_processnegative regulation of neuron apoptotic process
L0046928biological_processregulation of neurotransmitter secretion
L0048168biological_processregulation of neuronal synaptic plasticity
L0048169biological_processregulation of long-term neuronal synaptic plasticity
L0048489biological_processsynaptic vesicle transport
L0050806biological_processpositive regulation of synaptic transmission
L0050812biological_processregulation of acyl-CoA biosynthetic process
L0051259biological_processprotein complex oligomerization
L0051402biological_processneuron apoptotic process
L0060079biological_processexcitatory postsynaptic potential
L0060291biological_processlong-term synaptic potentiation
L0061024biological_processmembrane organization
L2000377biological_processregulation of reactive oxygen species metabolic process
L0030544molecular_functionHsp70 protein binding
L0022898biological_processregulation of transmembrane transporter activity
L0051621biological_processregulation of norepinephrine uptake
L0003779molecular_functionactin binding
L0043014molecular_functionalpha-tubulin binding
L1904377biological_processpositive regulation of protein localization to cell periphery
L1905606biological_processregulation of presynapse assembly
L0019894molecular_functionkinesin binding
L0070840molecular_functiondynein complex binding
L0008289molecular_functionlipid binding
L0060090molecular_functionmolecular adaptor activity
L1990000biological_processamyloid fibril formation
L0000149molecular_functionSNARE binding
L0000287molecular_functionmagnesium ion binding
L0001921biological_processpositive regulation of receptor recycling
L0005504molecular_functionfatty acid binding
L0005507molecular_functioncopper ion binding
L0005509molecular_functioncalcium ion binding
L0005543molecular_functionphospholipid binding
L0005615cellular_componentextracellular space
L0005938cellular_componentcell cortex
L0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
L0008198molecular_functionferrous iron binding
L0008270molecular_functionzinc ion binding
L0010040biological_processresponse to iron(II) ion
L0010517biological_processregulation of phospholipase activity
L0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
L0015629cellular_componentactin cytoskeleton
L0016079biological_processsynaptic vesicle exocytosis
L0016491molecular_functionoxidoreductase activity
L0030426cellular_componentgrowth cone
L0031092cellular_componentplatelet alpha granule membrane
L0031115biological_processnegative regulation of microtubule polymerization
L0031623biological_processreceptor internalization
L0031648biological_processprotein destabilization
L0032026biological_processresponse to magnesium ion
L0032410biological_processnegative regulation of transporter activity
L0032496biological_processresponse to lipopolysaccharide
L0032769biological_processnegative regulation of monooxygenase activity
L0034341biological_processresponse to type II interferon
L0035543biological_processpositive regulation of SNARE complex assembly
L0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
L0045807biological_processpositive regulation of endocytosis
L0048156molecular_functiontau protein binding
L0048471cellular_componentperinuclear region of cytoplasm
L0050729biological_processpositive regulation of inflammatory response
L0051219molecular_functionphosphoprotein binding
L0051262biological_processprotein tetramerization
L0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
L0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
L0051612biological_processnegative regulation of serotonin uptake
L0051622biological_processnegative regulation of norepinephrine uptake
L0055074biological_processcalcium ion homeostasis
L0060732biological_processpositive regulation of inositol phosphate biosynthetic process
L0060961molecular_functionphospholipase D inhibitor activity
L0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
L0070555biological_processresponse to interleukin-1
L0071280biological_processcellular response to copper ion
L0071902biological_processpositive regulation of protein serine/threonine kinase activity
L0099512cellular_componentsupramolecular fiber
L1903284biological_processpositive regulation of glutathione peroxidase activity
L1903285biological_processpositive regulation of hydrogen peroxide catabolic process
L0016082biological_processsynaptic vesicle priming
L0032991cellular_componentprotein-containing complex
L0043066biological_processnegative regulation of apoptotic process
L0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
L0045920biological_processnegative regulation of exocytosis
L0045921biological_processpositive regulation of exocytosis
L1904715biological_processnegative regulation of chaperone-mediated autophagy
L0000122biological_processnegative regulation of transcription by RNA polymerase II
L0000976molecular_functiontranscription cis-regulatory region binding
L0004860molecular_functionprotein kinase inhibitor activity
L0005739cellular_componentmitochondrion
L0005764cellular_componentlysosome
L0006469biological_processnegative regulation of protein kinase activity
L0043065biological_processpositive regulation of apoptotic process
L0051583biological_processdopamine uptake involved in synaptic transmission
L0071872biological_processcellular response to epinephrine stimulus
L0097435biological_processsupramolecular fiber organization
L1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
L1903421biological_processregulation of synaptic vesicle recycling
L1903426biological_processregulation of reactive oxygen species biosynthetic process
M0098794cellular_componentpostsynapse
M0034599biological_processcellular response to oxidative stress
M0050808biological_processsynapse organization
M0007268biological_processchemical synaptic transmission
M0043025cellular_componentneuronal cell body
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Q0030424cellular_componentaxon
Q0005515molecular_functionprotein binding
Q0033138biological_processpositive regulation of peptidyl-serine phosphorylation
Q0001774biological_processmicroglial cell activation
Q0001956biological_processpositive regulation of neurotransmitter secretion
Q0001963biological_processsynaptic transmission, dopaminergic
Q0005829cellular_componentcytosol
Q0005856cellular_componentcytoskeleton
Q0005886cellular_componentplasma membrane
Q0006631biological_processfatty acid metabolic process
Q0006638biological_processneutral lipid metabolic process
Q0006644biological_processphospholipid metabolic process
Q0007006biological_processmitochondrial membrane organization
Q0007269biological_processneurotransmitter secretion
Q0008344biological_processadult locomotory behavior
Q0009410biological_processresponse to xenobiotic stimulus
Q0014048biological_processregulation of glutamate secretion
Q0014059biological_processregulation of dopamine secretion
Q0016234cellular_componentinclusion body
Q0030672cellular_componentsynaptic vesicle membrane
Q0035493biological_processSNARE complex assembly
Q0040012biological_processregulation of locomotion
Q0042393molecular_functionhistone binding
Q0042416biological_processdopamine biosynthetic process
Q0042417biological_processdopamine metabolic process
Q0042775biological_processmitochondrial ATP synthesis coupled electron transport
Q0042802molecular_functionidentical protein binding
Q0043030biological_processregulation of macrophage activation
Q0043524biological_processnegative regulation of neuron apoptotic process
Q0046928biological_processregulation of neurotransmitter secretion
Q0048168biological_processregulation of neuronal synaptic plasticity
Q0048169biological_processregulation of long-term neuronal synaptic plasticity
Q0048489biological_processsynaptic vesicle transport
Q0050806biological_processpositive regulation of synaptic transmission
Q0050812biological_processregulation of acyl-CoA biosynthetic process
Q0051259biological_processprotein complex oligomerization
Q0051402biological_processneuron apoptotic process
Q0060079biological_processexcitatory postsynaptic potential
Q0060291biological_processlong-term synaptic potentiation
Q0061024biological_processmembrane organization
Q2000377biological_processregulation of reactive oxygen species metabolic process
Q0030544molecular_functionHsp70 protein binding
Q0022898biological_processregulation of transmembrane transporter activity
Q0051621biological_processregulation of norepinephrine uptake
Q0003779molecular_functionactin binding
Q0043014molecular_functionalpha-tubulin binding
Q1904377biological_processpositive regulation of protein localization to cell periphery
Q1905606biological_processregulation of presynapse assembly
Q0019894molecular_functionkinesin binding
Q0070840molecular_functiondynein complex binding
Q0008289molecular_functionlipid binding
Q0060090molecular_functionmolecular adaptor activity
Q1990000biological_processamyloid fibril formation
Q0000149molecular_functionSNARE binding
Q0000287molecular_functionmagnesium ion binding
Q0001921biological_processpositive regulation of receptor recycling
Q0005504molecular_functionfatty acid binding
Q0005507molecular_functioncopper ion binding
Q0005509molecular_functioncalcium ion binding
Q0005543molecular_functionphospholipid binding
Q0005615cellular_componentextracellular space
Q0005938cellular_componentcell cortex
Q0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
Q0008198molecular_functionferrous iron binding
Q0008270molecular_functionzinc ion binding
Q0010040biological_processresponse to iron(II) ion
Q0010517biological_processregulation of phospholipase activity
Q0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
Q0015629cellular_componentactin cytoskeleton
Q0016079biological_processsynaptic vesicle exocytosis
Q0016491molecular_functionoxidoreductase activity
Q0030426cellular_componentgrowth cone
Q0031092cellular_componentplatelet alpha granule membrane
Q0031115biological_processnegative regulation of microtubule polymerization
Q0031623biological_processreceptor internalization
Q0031648biological_processprotein destabilization
Q0032026biological_processresponse to magnesium ion
Q0032410biological_processnegative regulation of transporter activity
Q0032496biological_processresponse to lipopolysaccharide
Q0032769biological_processnegative regulation of monooxygenase activity
Q0034341biological_processresponse to type II interferon
Q0035543biological_processpositive regulation of SNARE complex assembly
Q0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
Q0045807biological_processpositive regulation of endocytosis
Q0048156molecular_functiontau protein binding
Q0048471cellular_componentperinuclear region of cytoplasm
Q0050729biological_processpositive regulation of inflammatory response
Q0051219molecular_functionphosphoprotein binding
Q0051262biological_processprotein tetramerization
Q0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
Q0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
Q0051612biological_processnegative regulation of serotonin uptake
Q0051622biological_processnegative regulation of norepinephrine uptake
Q0055074biological_processcalcium ion homeostasis
Q0060732biological_processpositive regulation of inositol phosphate biosynthetic process
Q0060961molecular_functionphospholipase D inhibitor activity
Q0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
Q0070555biological_processresponse to interleukin-1
Q0071280biological_processcellular response to copper ion
Q0071902biological_processpositive regulation of protein serine/threonine kinase activity
Q0099512cellular_componentsupramolecular fiber
Q1903284biological_processpositive regulation of glutathione peroxidase activity
Q1903285biological_processpositive regulation of hydrogen peroxide catabolic process
Q0016082biological_processsynaptic vesicle priming
Q0032991cellular_componentprotein-containing complex
Q0043066biological_processnegative regulation of apoptotic process
Q0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Q0045920biological_processnegative regulation of exocytosis
Q0045921biological_processpositive regulation of exocytosis
Q1904715biological_processnegative regulation of chaperone-mediated autophagy
Q0000122biological_processnegative regulation of transcription by RNA polymerase II
Q0000976molecular_functiontranscription cis-regulatory region binding
Q0004860molecular_functionprotein kinase inhibitor activity
Q0005739cellular_componentmitochondrion
Q0005764cellular_componentlysosome
Q0006469biological_processnegative regulation of protein kinase activity
Q0043065biological_processpositive regulation of apoptotic process
Q0051583biological_processdopamine uptake involved in synaptic transmission
Q0071872biological_processcellular response to epinephrine stimulus
Q0097435biological_processsupramolecular fiber organization
Q1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
Q1903421biological_processregulation of synaptic vesicle recycling
Q1903426biological_processregulation of reactive oxygen species biosynthetic process
R0098794cellular_componentpostsynapse
R0034599biological_processcellular response to oxidative stress
R0050808biological_processsynapse organization
R0007268biological_processchemical synaptic transmission
R0043025cellular_componentneuronal cell body
R0005737cellular_componentcytoplasm
R0048488biological_processsynaptic vesicle endocytosis
R0043679cellular_componentaxon terminus
R1903136molecular_functioncuprous ion binding
R0016020cellular_componentmembrane
R0046872molecular_functionmetal ion binding
R0005634cellular_componentnucleus
R0045202cellular_componentsynapse
R0005576cellular_componentextracellular region
R0042995cellular_componentcell projection
R0030424cellular_componentaxon
R0005515molecular_functionprotein binding
R0033138biological_processpositive regulation of peptidyl-serine phosphorylation
R0001774biological_processmicroglial cell activation
R0001956biological_processpositive regulation of neurotransmitter secretion
R0001963biological_processsynaptic transmission, dopaminergic
R0005829cellular_componentcytosol
R0005856cellular_componentcytoskeleton
R0005886cellular_componentplasma membrane
R0006631biological_processfatty acid metabolic process
R0006638biological_processneutral lipid metabolic process
R0006644biological_processphospholipid metabolic process
R0007006biological_processmitochondrial membrane organization
R0007269biological_processneurotransmitter secretion
R0008344biological_processadult locomotory behavior
R0009410biological_processresponse to xenobiotic stimulus
R0014048biological_processregulation of glutamate secretion
R0014059biological_processregulation of dopamine secretion
R0016234cellular_componentinclusion body
R0030672cellular_componentsynaptic vesicle membrane
R0035493biological_processSNARE complex assembly
R0040012biological_processregulation of locomotion
R0042393molecular_functionhistone binding
R0042416biological_processdopamine biosynthetic process
R0042417biological_processdopamine metabolic process
R0042775biological_processmitochondrial ATP synthesis coupled electron transport
R0042802molecular_functionidentical protein binding
R0043030biological_processregulation of macrophage activation
R0043524biological_processnegative regulation of neuron apoptotic process
R0046928biological_processregulation of neurotransmitter secretion
R0048168biological_processregulation of neuronal synaptic plasticity
R0048169biological_processregulation of long-term neuronal synaptic plasticity
R0048489biological_processsynaptic vesicle transport
R0050806biological_processpositive regulation of synaptic transmission
R0050812biological_processregulation of acyl-CoA biosynthetic process
R0051259biological_processprotein complex oligomerization
R0051402biological_processneuron apoptotic process
R0060079biological_processexcitatory postsynaptic potential
R0060291biological_processlong-term synaptic potentiation
R0061024biological_processmembrane organization
R2000377biological_processregulation of reactive oxygen species metabolic process
R0030544molecular_functionHsp70 protein binding
R0022898biological_processregulation of transmembrane transporter activity
R0051621biological_processregulation of norepinephrine uptake
R0003779molecular_functionactin binding
R0043014molecular_functionalpha-tubulin binding
R1904377biological_processpositive regulation of protein localization to cell periphery
R1905606biological_processregulation of presynapse assembly
R0019894molecular_functionkinesin binding
R0070840molecular_functiondynein complex binding
R0008289molecular_functionlipid binding
R0060090molecular_functionmolecular adaptor activity
R1990000biological_processamyloid fibril formation
R0000149molecular_functionSNARE binding
R0000287molecular_functionmagnesium ion binding
R0001921biological_processpositive regulation of receptor recycling
R0005504molecular_functionfatty acid binding
R0005507molecular_functioncopper ion binding
R0005509molecular_functioncalcium ion binding
R0005543molecular_functionphospholipid binding
R0005615cellular_componentextracellular space
R0005938cellular_componentcell cortex
R0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
R0008198molecular_functionferrous iron binding
R0008270molecular_functionzinc ion binding
R0010040biological_processresponse to iron(II) ion
R0010517biological_processregulation of phospholipase activity
R0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
R0015629cellular_componentactin cytoskeleton
R0016079biological_processsynaptic vesicle exocytosis
R0016491molecular_functionoxidoreductase activity
R0030426cellular_componentgrowth cone
R0031092cellular_componentplatelet alpha granule membrane
R0031115biological_processnegative regulation of microtubule polymerization
R0031623biological_processreceptor internalization
R0031648biological_processprotein destabilization
R0032026biological_processresponse to magnesium ion
R0032410biological_processnegative regulation of transporter activity
R0032496biological_processresponse to lipopolysaccharide
R0032769biological_processnegative regulation of monooxygenase activity
R0034341biological_processresponse to type II interferon
R0035543biological_processpositive regulation of SNARE complex assembly
R0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
R0045807biological_processpositive regulation of endocytosis
R0048156molecular_functiontau protein binding
R0048471cellular_componentperinuclear region of cytoplasm
R0050729biological_processpositive regulation of inflammatory response
R0051219molecular_functionphosphoprotein binding
R0051262biological_processprotein tetramerization
R0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
R0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
R0051612biological_processnegative regulation of serotonin uptake
R0051622biological_processnegative regulation of norepinephrine uptake
R0055074biological_processcalcium ion homeostasis
R0060732biological_processpositive regulation of inositol phosphate biosynthetic process
R0060961molecular_functionphospholipase D inhibitor activity
R0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
R0070555biological_processresponse to interleukin-1
R0071280biological_processcellular response to copper ion
R0071902biological_processpositive regulation of protein serine/threonine kinase activity
R0099512cellular_componentsupramolecular fiber
R1903284biological_processpositive regulation of glutathione peroxidase activity
R1903285biological_processpositive regulation of hydrogen peroxide catabolic process
R0016082biological_processsynaptic vesicle priming
R0032991cellular_componentprotein-containing complex
R0043066biological_processnegative regulation of apoptotic process
R0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
R0045920biological_processnegative regulation of exocytosis
R0045921biological_processpositive regulation of exocytosis
R1904715biological_processnegative regulation of chaperone-mediated autophagy
R0000122biological_processnegative regulation of transcription by RNA polymerase II
R0000976molecular_functiontranscription cis-regulatory region binding
R0004860molecular_functionprotein kinase inhibitor activity
R0005739cellular_componentmitochondrion
R0005764cellular_componentlysosome
R0006469biological_processnegative regulation of protein kinase activity
R0043065biological_processpositive regulation of apoptotic process
R0051583biological_processdopamine uptake involved in synaptic transmission
R0071872biological_processcellular response to epinephrine stimulus
R0097435biological_processsupramolecular fiber organization
R1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
R1903421biological_processregulation of synaptic vesicle recycling
R1903426biological_processregulation of reactive oxygen species biosynthetic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
IASP2
MHIS50
NASP2
NHIS50
OASP2
OHIS50
PASP2
PHIS50
QASP2
QHIS50
RASP2
IHIS50
RHIS50
JASP2
JHIS50
KASP2
KHIS50
LASP2
LHIS50
MASP2

site_idSWS_FT_FI2
Number of Residues10
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:22407793
ChainResidueDetails
IMET1
RMET1
JMET1
KMET1
LMET1
MMET1
NMET1
OMET1
PMET1
QMET1

site_idSWS_FT_FI3
Number of Residues10
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617630
ChainResidueDetails
ISER87
RSER87
JSER87
KSER87
LSER87
MSER87
NSER87
OSER87
PSER87
QSER87

site_idSWS_FT_FI4
Number of Residues10
DetailsMOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:12893833
ChainResidueDetails
ITYR125
RTYR125
JTYR125
KTYR125
LTYR125
MTYR125
NTYR125
OTYR125
PTYR125
QTYR125

site_idSWS_FT_FI5
Number of Residues10
DetailsMOD_RES: Phosphoserine; by BARK1, PLK2, CK2, CK1 and GRK5 => ECO:0000269|PubMed:10617630, ECO:0000269|PubMed:11813001, ECO:0000269|PubMed:24936070
ChainResidueDetails
ISER129
RSER129
JSER129
KSER129
LSER129
MSER129
NSER129
OSER129
PSER129
QSER129

223790

PDB entries from 2024-08-14

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