8PFP
Crystal structure of WRN helicase domain in complex with ATPgammaS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | polymer | 431 | 48740.2 | 1 | UniProt (Q14191) Pfam (PF00270) Pfam (PF00271) Pfam (PF16124) | Homo sapiens (human) | DNA helicase,RecQ-like type 3,RecQ protein-like 2,Werner syndrome protein |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 1 | Chemie (AGS) | |||
| 4 | D (A) | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A: 517 - 945 (UniProt: Q14191)
| PDB | External Database | Details |
|---|---|---|
| Gly 515 | - | expression tag |
| Pro 516 | - | expression tag |
| Ala 625 | Glu 625 | engineered mutation |
| Ala 716 | Arg 716 | engineered mutation |
| Ala 804 | Lys 804 | engineered mutation |
| Ala 886 | Glu 886 | engineered mutation |
| Ala 942 | Arg 942 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48740.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 588.7 | |
| All* | Total formula weight | 49328.8 |
