8PEA

OXA-48_F72L. Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Beta-lactamase	polymer	265	30362.7	2	UniProt (Q6XEC0) Pfam (PF00905) In PDB	Klebsiella pneumoniae
2	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
3		water	water		18.0	295	Chemie (HOH)

Sequence modifications

A, B: 1 - 265 (UniProt: Q6XEC0)

PDB	External Database	Details
Leu 72	Phe 72	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	60725.4
Non-Polymers*	Number of molecules	1
	Total formula weight	35.5
All*	Total formula weight	60760.9

*Water molecules are not included.