8PEA
OXA-48_F72L. Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Beta-lactamase | polymer | 265 | 30362.7 | 2 | UniProt (Q6XEC0) Pfam (PF00905) | Klebsiella pneumoniae | |
| 2 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 265 (UniProt: Q6XEC0)
| PDB | External Database | Details |
|---|---|---|
| Leu 72 | Phe 72 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60725.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 35.5 | |
| All* | Total formula weight | 60760.9 |
