8PD6
Crystal structure of the TRIM58 PRY-SPRY domain in complex with TRIM-473
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | E3 ubiquitin-protein ligase TRIM58 | polymer | 218 | 24234.6 | 1 | UniProt (Q8NG06) Pfam (PF13765) Pfam (PF00622) In PDB | Homo sapiens (human) | Protein BIA2,RING-type E3 ubiquitin transferase TRIM58,Tripartite motif-containing protein 58 |
| 2 | A | ~{N}2-[3-(dimethylamino)propyl]-6-phenyl-~{N}4-(piperidin-4-ylmethyl)quinazoline-2,4-diamine | non-polymer | 418.6 | 1 | Chemie (YCB) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A: 251 - 466 (UniProt: Q8NG06)
| PDB | External Database | Details |
|---|---|---|
| Gly 249 | - | expression tag |
| Pro 250 | - | expression tag |
| Ser 277 | Cys 277 | engineered mutation |
| Ser 278 | Cys 278 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24234.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 564.7 | |
| All* | Total formula weight | 24799.3 |
