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8PBI

Mutant R1617Q of the dihydroorotase domain of human CAD protein bound to the inhibitor fluoroorotate

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
CAD proteinpolymer36239665.41UniProt (P27708)
Pfam (PF01979)
Homo sapiens (human)
2B
(A)
5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACIDnon-polymer174.11Chemie (FOT)
3C, D, E
(A)
FORMIC ACIDnon-polymer46.03Chemie (FMT)
4F, G
(A)
ZINC IONnon-polymer65.42Chemie (ZN)
5H
(A)
waterwater18.0370Chemie (HOH)
Sequence modifications
A: 1460 - 1821 (UniProt: P27708)
PDBExternal DatabaseDetails
Gln 1617Arg 1617engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight39665.4
Non-Polymers*Number of molecules6
Total formula weight443.0
All*Total formula weight40108.3
*Water molecules are not included.

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PDB entries from 2024-11-20

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