8PAR
Crystal structure of human MAP4K1 with an inhibitor, BAY-405
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase kinase kinase kinase 1 | polymer | 308 | 34417.8 | 1 | UniProt (Q92918) Pfam (PF00069) | Homo sapiens (human) | Hematopoietic progenitor kinase,MAPK/ERK kinase kinase kinase 1,MEK kinase kinase 1,MEKKK 1 |
| 2 | B (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | C (A) | ~{N}-[3,5-bis(fluoranyl)-4-[[3-[1-(trifluoromethyl)cyclopropyl]-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]-2,9-dioxa-4-azaspiro[5.5]undec-3-en-3-amine | non-polymer | 522.5 | 1 | Chemie (XON) | |||
| 4 | D (A) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A: 1 - 307 (UniProt: Q92918)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Glu 165 | Thr 165 | engineered mutation |
| Glu 171 | Ser 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34417.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 614.6 | |
| All* | Total formula weight | 35032.4 |
