8P5H
Kinase domain of mutant human ULK1 in complex with compound CCT241533
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Serine/threonine-protein kinase ULK1 | polymer | 284 | 32121.1 | 2 | UniProt (O75385) Pfam (PF00069) In PDB | Homo sapiens (human) | Autophagy-related protein 1 homolog,ATG1,hATG1,Unc-51-like kinase 1 |
| 2 | A, B | 4-FLUORO-2-(4-{[(3S,4R)-4-(1-HYDROXY-1-METHYLETHYL)PYRROLIDIN-3-YL]AMINO}-6,7-DIMETHOXYQUINAZOLIN-2-YL)PHENOL | non-polymer | 442.5 | 2 | Chemie (XBJ) | |||
| 3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | water | water | 18.0 | 348 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 283 (UniProt: O75385)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Ala 245 | Arg 245 | engineered mutation |
| Ala 246 | Glu 246 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64242.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1028.2 | |
| All* | Total formula weight | 65270.4 |
