8P03

48S late-stage initiation complex with m6A mRNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	1	initiator methionylated tRNA	polymer	75	24376.6	1		Oryctolagus cuniculus
2	2	18S ribosomal RNA	polymer	1863	601015.7	1		Oryctolagus cuniculus
3	3	m6A-methylated mRNA	polymer	9	2882.8	1		Oryctolagus cuniculus
4	A	Eukaryotic translation initiation factor 2 subunit 1	polymer	284	32792.9	1	UniProt (G1T2G4) Pfam (PF00575) Pfam (PF07541) In PDB	Oryctolagus cuniculus (rabbit)
5	C	40S ribosomal protein SA	polymer	207	23273.7	1	UniProt (G1TLT8) Pfam (PF00318) In PDB	Oryctolagus cuniculus (rabbit)	37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40
6	D	ribosomal protein eS1	polymer	215	24944.4	1	UniProt (G1TN72) Pfam (PF01015) In PDB	Oryctolagus cuniculus (rabbit)
7	E	40S ribosomal protein S2	polymer	270	29100.0	1	UniProt (G1TUT9) In PDB	Oryctolagus cuniculus (rabbit)
8	F	Ribosomal protein S3	polymer	227	25158.5	1	UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) In PDB	Oryctolagus cuniculus (rabbit)
9	G	40S ribosomal protein S4	polymer	263	29658.9	1	UniProt (G1TK17) Pfam (PF00467) Pfam (PF16121) Pfam (PF08071) Pfam (PF00900) In PDB	Oryctolagus cuniculus (rabbit)
10	H	Ribosomal protein S5	polymer	191	21525.9	1	UniProt (U3KMN4) Pfam (PF00177) In PDB	Oryctolagus cuniculus (rabbit)
11	I	40S ribosomal protein S6	polymer	237	27475.5	1	UniProt (A0A5K1UJS7) Pfam (PF01092) In PDB	Oryctolagus cuniculus (rabbit)
12	J	ribosomal protein eS7	polymer	190	21716.4	1	UniProt (G1SVB0) In PDB	Oryctolagus cuniculus (rabbit)
13	K	40S ribosomal protein S8	polymer	206	23902.9	1	UniProt (G1TJW1) Pfam (PF01201) In PDB	Oryctolagus cuniculus (rabbit)
14	L	40S ribosomal protein S9	polymer	194	22641.6	1	UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) In PDB	Oryctolagus cuniculus (rabbit)
15	M	40S ribosomal protein eS10	polymer	98	11774.0	1	UniProt (G1TPV3) Pfam (PF03501) In PDB	Oryctolagus cuniculus (rabbit)
16	N	40S ribosomal protein S11	polymer	158	18468.8	1	UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) In PDB	Oryctolagus cuniculus (rabbit)
17	O	40S ribosomal protein S12	polymer	132	14539.0	1	UniProt (G1SFR8) Pfam (PF01248) In PDB	Oryctolagus cuniculus (rabbit)
18	P	ribosomal protein uS15	polymer	150	17128.2	1	UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) In PDB	Oryctolagus cuniculus (rabbit)
19	Q	40S ribosomal protein uS11	polymer	151	16302.8	1	UniProt (G1T1F0) Pfam (PF00411) In PDB	Oryctolagus cuniculus (rabbit)
20	R	40S ribosomal protein uS19	polymer	145	17049.2	1	UniProt (G1U0Q2) Pfam (PF00203) In PDB	Oryctolagus cuniculus (rabbit)
21	S	40S ribosomal protein uS9	polymer	141	15975.8	1	UniProt (G1SGX4) Pfam (PF00380) In PDB	Oryctolagus cuniculus (rabbit)
22	T	40S ribosomal protein eS17	polymer	135	15552.1	1	UniProt (G1TU13) Pfam (PF00833) In PDB	Oryctolagus cuniculus (rabbit)
23	U	40S ribosomal protein uS13	polymer	152	17759.8	1	UniProt (G1TPG3) Pfam (PF00416) In PDB	Oryctolagus cuniculus (rabbit)
24	V	40S ribosomal protein eS19	polymer	141	15812.3	1	UniProt (G1TN62) Pfam (PF01090) In PDB	Oryctolagus cuniculus (rabbit)
25	W	40S ribosomal protein uS10	polymer	119	13398.8	1	UniProt (G1SIZ2) Pfam (PF00338) In PDB	Oryctolagus cuniculus (rabbit)
26	X	40S ribosomal protein S21	polymer	83	9124.4	1	UniProt (Q32PB8) Pfam (PF01249) In PDB	Oryctolagus cuniculus (rabbit)
27	Y	Ribosomal protein S15a	polymer	130	14865.6	1	UniProt (G1TG89) Pfam (PF00410) In PDB	Oryctolagus cuniculus (rabbit)
28	Z	40S ribosomal protein S23	polymer	143	15844.7	1	UniProt (G1SZ47) Pfam (PF00164) In PDB	Oryctolagus cuniculus (rabbit)	RPS23
29	a	40S ribosomal protein S24	polymer	133	15434.3	1	UniProt (G1TS40) Pfam (PF01282) UniProt (by SIFTS) (A0A5F9D2E6) In PDB	Oryctolagus cuniculus (rabbit)
30	b	40S ribosomal protein S26	polymer	115	12961.5	1	UniProt (G1TFE8) Pfam (PF01283) In PDB	Oryctolagus cuniculus (rabbit)
31	c	40S ribosomal protein S27	polymer	84	9480.2	1	UniProt (G1TZ76) Pfam (PF01667) In PDB	Oryctolagus cuniculus (rabbit)
32	d	40S ribosomal protein S28	polymer	69	7855.1	1	UniProt (G1TIB4) Pfam (PF01200) In PDB	Oryctolagus cuniculus (rabbit)
33	e	40S ribosomal protein S29	polymer	56	6690.8	1	UniProt (G1U7M4) Pfam (PF00253) In PDB	Oryctolagus cuniculus (rabbit)	uS14
34	f	ribosomal protein eS31	polymer	71	8358.9	1	UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) In PDB	Oryctolagus cuniculus (rabbit)
35	g	Ribosomal protein RACK1	polymer	313	34669.1	1	UniProt (G1SJB4) Pfam (PF00400) In PDB	Oryctolagus cuniculus (rabbit)
36	i	40S ribosomal protein S30	polymer	133	14498.9	1	UniProt (G1T8A2) Pfam (PF00240) Pfam (PF04758) In PDB	Oryctolagus cuniculus (rabbit)
37	j	Eukaryotic translation initiation factor 4C	polymer	111	12788.8	1	UniProt (G1SYS4) Pfam (PF01176) In PDB	Oryctolagus cuniculus (rabbit)
38	k	ATP binding cassette subfamily E member 1	polymer	595	66986.8	1	UniProt (G1SG72) Pfam (PF04068) Pfam (PF00037) Pfam (PF00005) In PDB	Oryctolagus cuniculus (rabbit)
39	l	60S ribosomal protein L41	polymer	25	3473.5	1	UniProt (A0A087WNH4) Pfam (PF05162) In PDB	Oryctolagus cuniculus (rabbit)
40	n	40S ribosomal protein S25	polymer	124	13645.0	1	UniProt (G1TDB3) Pfam (PF03297) In PDB	Oryctolagus cuniculus (rabbit)
41	2, 3, I, Z	MAGNESIUM ION	non-polymer		24.3	178	Chemie (MG)

Sequence modifications

I: 1 - 237 (UniProt: A0A5K1UJS7)

PDB	External Database	Details
Thr 130	Pro 130	conflict

j: 5 - 115 (UniProt: G1SYS4)

PDB	External Database	Details
Ile 39	Val 39	conflict
Ile 76	Val 76	conflict

k: 4 - 598 (UniProt: G1SG72)

PDB	External Database	Details
Ile 538	Val 538	conflict

Contents of the asymmetric unit

Polymers	Number of chains	40
	Total formula weight	1330903.8
Non-Polymers*	Number of molecules	178
	Total formula weight	4326.3
All*	Total formula weight	1335230.1

*Water molecules are not included.