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8OX9

Cryo-EM structure of ATP8B1-CDC50A in E2P active conformation with bound PC

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Phospholipid-transporting ATPase ICpolymer1185136283.51UniProt (O43520)
Pfam (PF16209)
Pfam (PF00122)
Pfam (PF13246)
Pfam (PF16212)
Homo sapiens (human)ATPase class I type 8B member 1,Familial intrahepatic cholestasis type 1,P4-ATPase flippase complex alpha subunit ATP8B1
2B
(B)
Cell cycle control protein 50Apolymer36541086.01UniProt (Q9NV96)
Pfam (PF03381)
Homo sapiens (human)P4-ATPase flippase complex beta subunit TMEM30A,Transmembrane protein 30A
3C
(C)
beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched586.51In PDB
GlyTouCan (G15407YE)
4D
(A)
BERYLLIUM TRIFLUORIDE IONnon-polymer66.01Chemie (BEF)
5E
(A)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
6F
(A)
(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphatenon-polymer760.11Chemie (POV)
7G
(A)
(2R)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dioctanoatenon-polymer826.51Chemie (IP9)
8H, I
(B)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.22Chemie (NAG)
9J
(A)
waterwater18.09Chemie (HOH)
Sequence modifications
A: 1 - 1185 (UniProt: O43520)
PDBExternal DatabaseDetails
Thr 1152Ala 1152variant
B: 1 - 361 (UniProt: Q9NV96)
PDBExternal DatabaseDetails
Met -3-initiating methionine
Leu -2-expression tag
Gly -1-expression tag
Gly 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight177369.5
BranchedNumber of molecules1
Total formula weight586.5
Non-Polymers*Number of molecules6
Total formula weight2119.4
All*Total formula weight180075.3
*Water molecules are not included.

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PDB entries from 2025-07-23

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