8OX4
Cryo-EM structure of ATP8B1-CDC50A in E1-ATP conformation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Phospholipid-transporting ATPase IC | polymer | 1185 | 136283.5 | 1 | UniProt (O43520) Pfam (PF16209) Pfam (PF00122) Pfam (PF13246) Pfam (PF16212) In PDB | Homo sapiens (human) | ATPase class I type 8B member 1,Familial intrahepatic cholestasis type 1,P4-ATPase flippase complex alpha subunit ATP8B1 |
2 | B | Cell cycle control protein 50A | polymer | 365 | 41086.0 | 1 | UniProt (Q9NV96) Pfam (PF03381) In PDB | Homo sapiens (human) | P4-ATPase flippase complex beta subunit TMEM30A,Transmembrane protein 30A |
3 | C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
4 | A | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
6 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
7 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 1 - 1185 (UniProt: O43520)
B: 1 - 361 (UniProt: Q9NV96)
PDB | External Database | Details |
---|---|---|
Thr 1152 | Ala 1152 | variant |
PDB | External Database | Details |
---|---|---|
Met -3 | - | initiating methionine |
Leu -2 | - | expression tag |
Gly -1 | - | expression tag |
Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 177369.5 | |
Branched | Number of molecules | 1 |
Total formula weight | 586.5 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 971.9 | |
All* | Total formula weight | 178927.9 |