8OWG
Crystal structure of D1228V c-MET bound by compound 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Hepatocyte growth factor receptor | polymer | 309 | 34826.4 | 3 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | D, E, F (A, B, C) | 5-[3,5-bis(fluoranyl)phenyl]-1-[(1S)-1-phenylethyl]pyrimidine-2,4-dione | non-polymer | 328.3 | 3 | Chemie (W40) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 113 | Chemie (HOH) |
Sequence modifications
A, B, C: 1038 - 1346 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Val 1228 | Asp 1228 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 104479.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 984.9 | |
| All* | Total formula weight | 105464.0 |
