8OW4

2.75 angstrom crystal structure of human NFAT1 with bound DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (A, B)	Nuclear factor of activated T-cells, cytoplasmic 2	polymer	298	33870.5	2	UniProt (Q13469) Pfam (PF00554) Pfam (PF16179)	Homo sapiens (human)	NF-ATc2,NFATc2,NFAT pre-existing subunit,NF-ATp,T-cell transcription factor NFAT1
2	B, D (W, G)	DNA (5'-D(*TP*TP*GP*CP*TP*GP*GP*AP*AP*AP*AP*AP*TP*AP*G)-3')	polymer	15	4657.1	2		Homo sapiens
3	C, E (C, H)	DNA (5'-D(*AP*AP*CP*TP*AP*TP*TP*TP*TP*TP*CP*CP*AP*GP*C)-3')	polymer	15	4519.0	2		Homo sapiens
4	G, H (A, B)	water	water		18.0	9	Chemie (HOH)

Sequence modifications

A, B: 391 - 678 (UniProt: Q13469)

PDB	External Database	Details
Met 381	-	initiating methionine
Ala 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
Val 389	-	expression tag
Gly 390	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	86093.1
All*	Total formula weight	86093.1

*Water molecules are not included.