8OVZ
Crystal structure of D1228V c-MET bound by compound 16
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hepatocyte growth factor receptor | polymer | 309 | 34826.4 | 2 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | C, D, E, F, G... (A, B) | IODIDE ION | non-polymer | 126.9 | 19 | Chemie (IOD) | |||
| 3 | M, W (A, B) | 1-[(1S)-1-[3-(1H-imidazol-4-yl)phenyl]ethyl]-5-(1H-indazol-7-yl)pyrimidine-2,4-dione | non-polymer | 398.4 | 2 | Chemie (W3N) | |||
| 4 | X, Y (A, B) | water | water | 18.0 | 171 | Chemie (HOH) |
Sequence modifications
A, B: 1038 - 1346 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Val 1228 | Asp 1228 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69652.7 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 3208.0 | |
| All* | Total formula weight | 72860.7 |
