8OUR
CRYSTAL STRUCTURE OF DLK IN COMPLEX WITH COMPOUND 16
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase kinase kinase 12 | polymer | 300 | 34018.0 | 1 | UniProt (Q12852) Pfam (PF07714) | Homo sapiens (human) | Dual leucine zipper bearing kinase,DLK,Leucine-zipper protein kinase,ZPK,MAPK-upstream kinase,MUK,Mixed lineage kinase |
| 2 | B (A) | 5-[1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)-2-propan-2-yl-imidazol-4-yl]-3-(trifluoromethyloxy)pyridin-2-amine | non-polymer | 437.5 | 1 | Chemie (W38) | |||
| 3 | C (A) | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A: 115 - 402 (UniProt: Q12852)
| PDB | External Database | Details |
|---|---|---|
| Met 112 | - | initiating methionine |
| Gly 113 | - | expression tag |
| Ser 114 | - | expression tag |
| Gly 403 | - | expression tag |
| Asn 404 | - | expression tag |
| Ser 405 | - | expression tag |
| His 406 | - | expression tag |
| His 407 | - | expression tag |
| His 408 | - | expression tag |
| His 409 | - | expression tag |
| His 410 | - | expression tag |
| His 411 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34018.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 437.5 | |
| All* | Total formula weight | 34455.5 |
