8OSJ

Cryo-EM structure of CLOCK-BMAL1 bound to a nucleosomal E-box at position SHL-6.2 (DNA conformation 1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	Histone H3.1	polymer	139	15719.4	2	UniProt (P68431) Pfam (PF00125) In PDB	Homo sapiens (human)	Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l
2	B, F	Histone H4	polymer	106	11676.7	2	UniProt (P62805) Pfam (PF15511) In PDB	Homo sapiens (human)
3	C, G	Histone H2A type 1-B/E	polymer	133	14447.8	2	UniProt (P04908) Pfam (PF00125) Pfam (PF16211) In PDB	Homo sapiens (human)	Histone H2A.2,Histone H2A/a,Histone H2A/m
4	D, H	Histone H2B type 1-J	polymer	128	14088.3	2	UniProt (P06899) Pfam (PF00125) In PDB	Homo sapiens (human)	Histone H2B.1,Histone H2B.r,H2B/r
5	I	DNA (124-MER)	polymer	153	47030.0	1		synthetic construct
6	J	DNA (124-MER)	polymer	153	47426.2	1		synthetic construct
7	M	Circadian locomoter output cycles protein kaput	polymer	375	43768.4	1	UniProt (O08785) Pfam (PF00010) Pfam (PF00989) Pfam (PF14598) In PDB	Mus musculus (house mouse)	mCLOCK
8	N	Basic helix-loop-helix ARNT-like protein 1	polymer	384	43821.2	1	UniProt (Q9WTL8) Pfam (PF00989) Pfam (PF14598) Pfam (PF00010) In PDB	Mus musculus (house mouse)	Arnt3,Aryl hydrocarbon receptor nuclear translocator-like protein 1,Brain and muscle ARNT-like 1

Sequence modifications

A, E: 0 - 135 (UniProt: P68431)

B, F: 0 - 102 (UniProt: P62805)

C, G: 0 - 129 (UniProt: P04908)

D, H: 0 - 124 (UniProt: P06899)

M: 26 - 395 (UniProt: O08785)

N: 69 - 447 (UniProt: Q9WTL8)

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.