8OQY
Structure of apo form of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Nicastrin | polymer | 717 | 79371.6 | 1 | UniProt (Q92542) Pfam (PF18266) Pfam (PF05450) In PDB | Homo sapiens (human) | |
2 | B | Presenilin-1 CTF12 | polymer | 467 | 52713.5 | 1 | UniProt (P49768) Pfam (PF01080) In PDB | Homo sapiens (human) | PS1-CTF12 |
3 | C | Gamma-secretase subunit APH-1B | polymer | 257 | 28480.8 | 1 | UniProt (Q8WW43) Pfam (PF06105) In PDB | Homo sapiens (human) | APH-1b,Aph-1beta,Presenilin-stabilization factor-like |
4 | D | Gamma-secretase subunit PEN-2 | polymer | 101 | 12038.0 | 1 | UniProt (Q9NZ42) Pfam (PF10251) In PDB | Homo sapiens (human) | Presenilin enhancer protein 2 |
5 | E, G, H | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
6 | F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 789.7 | 1 | In PDB GlyTouCan (G95663PY) | |||
7 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
8 | A, B, C | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 3 | Chemie (PC1) |
Sequence modifications
A: 1 - 709 (UniProt: Q92542)
PDB | External Database | Details |
---|---|---|
Gly 710 | - | expression tag |
Thr 711 | - | expression tag |
Leu 712 | - | expression tag |
Glu 713 | - | expression tag |
Val 714 | - | expression tag |
Leu 715 | - | expression tag |
Phe 716 | - | expression tag |
Gln 717 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 172604.0 | |
Branched | Number of molecules | 4 |
Total formula weight | 2062.9 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 3918.9 | |
All* | Total formula weight | 178585.8 |