8OHQ
Crystal structure of human heparanase in complex with competitive inhibitor derrived from siastatin B
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | AAA | Heparanase 50 kDa subunit | polymer | 385 | 43334.9 | 1 | UniProt (Q9Y251) Pfam (PF03662) In PDB | Homo sapiens (human) | |
| 2 | BBB | Heparanase 8 kDa subunit | polymer | 74 | 8273.5 | 1 | UniProt (Q9Y251) In PDB | Homo sapiens (human) | |
| 3 | AeA | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 4 | AAA | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 5 | AAA, BBB | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | AAA | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 7 | AAA | (3~{S},4~{S})-4,5,5-tris(oxidanyl)piperidine-3-carboxylic acid | non-polymer | 177.2 | 1 | Chemie (VGO) | |||
| 8 | water | water | 18.0 | 249 | Chemie (HOH) |
Sequence modifications
AAA: 160 - 543 (UniProt: Q9Y251)
| PDB | External Database | Details |
|---|---|---|
| Lys 159 | - | expression tag |
| Arg 307 | Lys 307 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51608.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 367.3 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1354.5 | |
| All* | Total formula weight | 53330.3 |
